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Hemodynamic data are critical for early recognition of clinical deterioration, prognostication, and guiding treatment decisions. This state-of-the-art review provides a practical guide to hemodynamic assessment, troubleshooting, and interpretation of hemodynamic variables assessed with RHC for clinicians treating patients with heart failure in the acute setting, including acute heart failure and cardiogenic shock as well as chronic heart failure and advanced disease states that may warrant LVAD or heart transplantation. A special focus is set on contextualizing hemodynamic variables within the clinical presentation to avoid diagnostic misclassification. In addition, opportunities for future research, including novel parameters as well as forward-thinking non-invasive technologies to inform hemodynamics, are discussed.<\/jats:p>","DOI":"10.1093\/eurheartj\/ehaf322","type":"journal-article","created":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T08:24:32Z","timestamp":1750062272000},"page":"3354-3372","source":"Crossref","is-referenced-by-count":15,"title":["Right heart catheterization in heart failure: indications, interpretation, and pitfalls"],"prefix":"10.1093","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8415-727X","authenticated-orcid":false,"given":"Katarina","family":"Zeder","sequence":"first","affiliation":[{"name":"The University of Maryland-Institute for Health Computing , 6116 Executive Blvd, Bethesda, MD 20852 ,","place":["USA"]},{"name":"Division of Pulmonology, Medical University of Graz , Graz ,","place":["Austria"]},{"name":"University of Maryland, School of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine , Baltimore, MD ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2193-602X","authenticated-orcid":false,"given":"Susanna","family":"Mak","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, University of Toronto , Toronto, ON ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4271-8670","authenticated-orcid":false,"given":"Nazzareno","family":"Galie","sequence":"additional","affiliation":[{"name":"Cardiology Unit, IRCCS AOUBO , Bologna ,","place":["Italy"]},{"name":"DIMEC Department, University of Bologna , Bologna ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6237-1470","authenticated-orcid":false,"given":"Stephan","family":"Rosenkranz","sequence":"additional","affiliation":[{"name":"Clinic III for Internal Medicine (Cardiology) and Center for Molecular Medicine (CMMC), and the Cologne Cardiovascular Research Center (CCRC), University of Cologne , Cologne ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6784-764X","authenticated-orcid":false,"given":"Bradley A","family":"Maron","sequence":"additional","affiliation":[{"name":"The University of Maryland-Institute for Health Computing , 6116 Executive Blvd, Bethesda, MD 20852 ,","place":["USA"]},{"name":"Department of Medicine, University of Maryland School of Medicine , Baltimore, MD ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,6,16]]},"reference":[{"key":"2025090719570997100_ehaf322-B1","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1056\/NEJM197008272830902","article-title":"Catheterization of the heart in man with use of a flow-directed balloon-tipped 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