{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T23:17:48Z","timestamp":1794352668642,"version":"4.9.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"40","license":[{"start":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T00:00:00Z","timestamp":1752019200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ultromics","id":[{"id":"https:\/\/ror.org\/047nm6v46","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000871","name":"Mayo Clinic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Accurate differentiation of cardiac amyloidosis (CA) from phenotypic mimics remains challenging using current clinical and echocardiographic techniques. The accuracy of a novel artificial intelligence (AI) screening algorithm for echocardiography-based CA detection was assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Utilizing a multisite, multiethnic dataset (n = 2612, 52% CA), a convolutional neural network was trained to differentiate CA from phenotypic controls using transthoracic apical four-chamber video clips. External validation was conducted globally across 18 sites including 597 CA cases and 2122 controls. Classification accuracy was assessed on the entire external validation dataset, and subgroup analyses were performed both on technetium pyrophosphate scintigraphy referrals, and individuals matched for age, sex, and wall thickness. Model accuracy was also compared with the transthyretin CA score and the increased wall thickness score within a subset of older heart failure with preserved ejection fraction patients with increased wall thickness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Cardiac amyloidosis patients and controls displayed similar age, sex, race, and comorbidities. After the removal of uncertain AI predictions (13%), model discrimination and classification were excellent for the entire external validation dataset [area under the receiver operating characteristic curve (AUROC) 0.93, sensitivity 85%, specificity 93%], irrespective of CA subtype (sensitivity: light-chain = 84%, wild-type transthyretin = 85%, and hereditary transthyretin = 86%). Performance was maintained in subgroup analysis in patients clinically referred for technetium pyrophosphate scintigraphy imaging (AUROC 0.86, sensitivity 77%, specificity 86%) and matched patients (AUROC 0.92, sensitivity 84%, specificity 91%). The AI model (AUROC 0.93) also outperformed transthyretin CA score (AUROC 0.73) and increased wall thickness (AUROC 0.80) scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This AI screening model\u2014using only an apical four-chamber view\u2014effectively differentiated CA from other causes of increased left ventricular wall thickness.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurheartj\/ehaf387","type":"journal-article","created":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T07:26:40Z","timestamp":1748244400000},"page":"4090-4101","source":"Crossref","is-referenced-by-count":61,"title":["Cardiac amyloidosis detection from a single echocardiographic video clip: a novel artificial intelligence-based screening tool"],"prefix":"10.1093","volume":"46","author":[{"given":"Jeremy A","family":"Slivnick","sequence":"first","affiliation":[{"name":"University of Chicago , Chicago, IL, 5758 South Maryland Avenue, M.C. 9067, Chicago, IL 60637, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Will","family":"Hawkes","sequence":"additional","affiliation":[{"name":"Ultromics, Ltd. , Cascade Way, Oxford Business Park, Oxford, OX4 2SU ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Ultromics, Ltd. , Cascade Way, Oxford Business Park, Oxford, OX4 2SU ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Woodward","sequence":"additional","affiliation":[{"name":"Ultromics, Ltd. , Cascade Way, Oxford Business Park, Oxford, OX4 2SU ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Akerman","sequence":"additional","affiliation":[{"name":"Ultromics, Ltd. , Cascade Way, Oxford Business Park, Oxford, OX4 2SU ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Gomez","sequence":"additional","affiliation":[{"name":"Ultromics, Ltd. , Cascade Way, Oxford Business Park, Oxford, OX4 2SU ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izhan","family":"Hamza","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic , 200 First Street SW, Rochester, MN 55905, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viral K","family":"Desai","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic , 200 First Street SW, Rochester, MN 55905, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary","family":"Barrett-O\u2019Keefe","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic , 200 First Street SW, Rochester, MN 55905, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha","family":"Grogan","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic , 200 First Street SW, Rochester, MN 55905, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Dispenzieri","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic , 200 First Street SW, Rochester, MN 55905, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1340-0647","authenticated-orcid":false,"given":"Christopher G","family":"Scott","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic , 200 First Street SW, Rochester, MN 55905, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halley N","family":"Davison","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic , 200 First Street SW, Rochester, MN 55905, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Cotella","sequence":"additional","affiliation":[{"name":"University of Chicago , Chicago, IL, 5758 South Maryland Avenue, M.C. 9067, Chicago, IL 60637, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathew","family":"Maurer","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Columbia University , 622 West 168th Street, PH12-134, New York, NY 10032, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Helmke","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Columbia University , 622 West 168th Street, PH12-134, New York, NY 10032, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marielle","family":"Scherrer-Crosbie","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, University of Pennsylvania , Hospital of the University of Pennsylvania, Room 11-131, 11th Floor South Pavilion, 3400 Civic Center Blvd., Philadelphia, PA 19104, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwa","family":"Soltani","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, University of Pennsylvania , Hospital of the University of Pennsylvania, Room 11-131, 11th Floor South Pavilion, 3400 Civic Center Blvd., Philadelphia, PA 19104, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akash","family":"Goyal","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Ohio State University , 473 W. 12th Ave, Suite 200, Columbus, OH 43210, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolina M","family":"Zareba","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Ohio State University , 473 W. 12th Ave, Suite 200, Columbus, OH 43210, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5994-5998","authenticated-orcid":false,"given":"Richard K","family":"Cheng","sequence":"additional","affiliation":[{"name":"Division of Cardiology, University of Washington , 1959 NE Pacific Street, Box 356422, Seattle, WA 98195-6422, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0877-7618","authenticated-orcid":false,"given":"James N","family":"Kirkpatrick","sequence":"additional","affiliation":[{"name":"Division of Cardiology, University of Washington , 1959 NE Pacific Street, Box 356422, Seattle, WA 98195-6422, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuji","family":"Kitano","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital of University of Occupational and Environmental Health , 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaaki","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital of University of Occupational and Environmental Health , 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviane","family":"Tiemi Hotta","sequence":"additional","affiliation":[{"name":"Clinical Unity of Cardiomyopathies, Heart Institute (InCor) , Av. Dr. En\u00e9as Carvalho de Aguiar, 44, Cerqueira Cezar, Sao Paolo CEP: 05403\/000 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo Luiz","family":"Campos Vieira","sequence":"additional","affiliation":[{"name":"Clinical Unity of Cardiomyopathies, Heart Institute (InCor) , Av. Dr. En\u00e9as Carvalho de Aguiar, 44, Cerqueira Cezar, Sao Paolo CEP: 05403\/000 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Elissamburu","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Imaging, ICBA , Blanco Encalada 1543 street \u2013 C1428DCO, CABA ,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo E","family":"Ronderos","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Imaging, ICBA , Blanco Encalada 1543 street \u2013 C1428DCO, CABA ,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aldo","family":"Prado","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Centro Privado de Cardiolog\u00eda , Virgen De La Merced 550, Tucuman ,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6757-6480","authenticated-orcid":false,"given":"Efstratios","family":"Koutroumpakis","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University of Texas MD Anderson Cancer Center , 1515 Holcombe Blvd Unit 1451, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6147-9591","authenticated-orcid":false,"given":"Anita","family":"Deswal","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University of Texas MD Anderson Cancer Center , 1515 Holcombe Blvd Unit 1451, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5616-8839","authenticated-orcid":false,"given":"Amit","family":"Pursnani","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Endeavor Health - NorthShore Cardiovascular Institute, Walgreen Building 3rd Floor, 2650 Ridge Ave , Evanston, IL 60201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitasha","family":"Sarswat","sequence":"additional","affiliation":[{"name":"University of Chicago , Chicago, IL, 5758 South Maryland Avenue, M.C. 9067, Chicago, IL 60637, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit R","family":"Patel","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, University of Virginia Medical Center , 1215 Lee Street, PO Box Charlottesville, VA 800158, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karima","family":"Addetia","sequence":"additional","affiliation":[{"name":"University of Chicago , Chicago, IL, 5758 South Maryland Avenue, M.C. 9067, Chicago, IL 60637, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick L","family":"Ruberg","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Boston University Chobanian & Avedisian School of Medicine , 821 Collamore Building, 72 East Concord Street, Boston, MA 02118-2308, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Randazzo","sequence":"additional","affiliation":[{"name":"University of Chicago , Chicago, IL, 5758 South Maryland Avenue, M.C. 9067, Chicago, IL 60637, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico M","family":"Asch","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Core Labs, MedStar Health Research Institute , 100 Irving St NW, Ste EB5123, Washington, DC 20010, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie","family":"O\u2019Driscoll","sequence":"additional","affiliation":[{"name":"Diabetes Research Centre, College of Life Sciences, University of Leicester , Gwendolen Road, Leicester LE5 4PW, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora","family":"Al-Roub","sequence":"additional","affiliation":[{"name":"Richard A. and Susan F. SmithCenter for Outcomes Research in Cardiology, MASCO 4375 Longwood Ave., Boston, MA 02215 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan B","family":"Strom","sequence":"additional","affiliation":[{"name":"Richard A. and Susan F. SmithCenter for Outcomes Research in Cardiology, MASCO 4375 Longwood Ave., Boston, MA 02215 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liam","family":"Kidd","sequence":"additional","affiliation":[{"name":"Brigham & Women\u2019s Hospital , 75 Francis Street, Boston, MA 02115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Cuddy","sequence":"additional","affiliation":[{"name":"Brigham & Women\u2019s Hospital , 75 Francis Street, Boston, MA 02115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross","family":"Upton","sequence":"additional","affiliation":[{"name":"Ultromics, Ltd. , Cascade Way, Oxford Business Park, Oxford, OX4 2SU ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto M","family":"Lang","sequence":"additional","affiliation":[{"name":"University of Chicago , Chicago, IL, 5758 South Maryland Avenue, M.C. 9067, Chicago, IL 60637, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6800-3521","authenticated-orcid":false,"given":"Patricia A","family":"Pellikka","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic , 200 First Street SW, Rochester, MN 55905, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,7,9]]},"reference":[{"key":"2025102119532950900_ehaf387-B1","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1056\/NEJMoa1805689","article-title":"Tafamidis treatment for patients with transthyretin amyloid cardiomyopathy","volume":"379","author":"Maurer","year":"2018","journal-title":"N Engl J Med"},{"key":"2025102119532950900_ehaf387-B2","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1016\/j.jchf.2019.07.007","article-title":"A changing landscape of mortality for systemic light chain amyloidosis","volume":"7","author":"Barrett","year":"2019","journal-title":"JACC Heart Fail"},{"key":"2025102119532950900_ehaf387-B3","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1016\/j.jacc.2022.11.022","article-title":"2023 ACC expert consensus decision pathway on comprehensive multidisciplinary care for the patient with cardiac amyloidosis: a report of the American College of Cardiology solution set oversight committee","volume":"81","author":"Writing","year":"2023","journal-title":"J Am Coll Cardiol"},{"key":"2025102119532950900_ehaf387-B4","doi-asserted-by":"publisher","first-page":"3503","DOI":"10.1093\/eurheartj\/ehad194","article-title":"2023 ESC guidelines for the management of cardiomyopathies","volume":"44","author":"Arbelo","year":"2023","journal-title":"Eur Heart J"},{"key":"2025102119532950900_ehaf387-B5","doi-asserted-by":"publisher","first-page":"e000029","DOI":"10.1161\/HCI.0000000000000029","article-title":"ASNC\/AHA\/ASE\/EANM\/HFSA\/ISA\/SCMR\/SNMMI expert consensus recommendations for multimodality imaging in cardiac amyloidosis: part 1 of 2-evidence base and standardized methods of imaging","volume":"14","author":"Dorbala","year":"2021","journal-title":"Circ Cardiovasc Imaging"},{"key":"2025102119532950900_ehaf387-B6","doi-asserted-by":"publisher","first-page":"e014645","DOI":"10.1161\/circimaging.122.014645","article-title":"Optimal echocardiographic parameters to improve the diagnostic yield of Tc-99m-bone avid tracer cardiac scintigraphy for transthyretin cardiac amyloidosis","volume":"15","author":"Cuddy","year":"2022","journal-title":"Circ Cardiovasc Imaging"},{"key":"2025102119532950900_ehaf387-B7","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1001\/jamacardio.2022.1781","article-title":"A simple score to identify increased risk of transthyretin amyloid cardiomyopathy in heart failure with preserved ejection fraction","volume":"7","author":"Davies","year":"2022","journal-title":"JAMA Cardiol"},{"key":"2025102119532950900_ehaf387-B8","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1016\/j.jcmg.2019.10.011","article-title":"Multiparametric echocardiography scores for the diagnosis of cardiac amyloidosis","volume":"13","author":"Boldrini","year":"2020","journal-title":"JACC Cardiovasc Imaging"},{"key":"2025102119532950900_ehaf387-B9","doi-asserted-by":"publisher","first-page":"e005588","DOI":"10.1161\/CIRCIMAGING.116.005588","article-title":"Echo parameters for differential diagnosis in cardiac amyloidosis: a head-to-head comparison of deformation and nondeformation parameters","volume":"10","author":"Pagourelias","year":"2017","journal-title":"Circ Cardiovasc Imaging"},{"key":"2025102119532950900_ehaf387-B10","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1002\/ehf2.13738","article-title":"Echocardiographic and clinical predictors of cardiac amyloidosis: limitations of apical sparing","volume":"9","author":"Kyrouac","year":"2022","journal-title":"ESC Heart Fail"},{"key":"2025102119532950900_ehaf387-B11","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1016\/j.echo.2013.12.010","article-title":"Advanced cardiac amyloidosis associated with normal interventricular septal thickness: an uncommon presentation of infiltrative cardiomyopathy","volume":"27","author":"Suresh","year":"2014","journal-title":"J Am Soc Echocardiogr"},{"key":"2025102119532950900_ehaf387-B12","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1080\/13506129.2018.1498782","article-title":"Seven factors predict a delayed diagnosis of cardiac amyloidosis","volume":"25","author":"Bishop","year":"2018","journal-title":"Amyloid"},{"key":"2025102119532950900_ehaf387-B13","doi-asserted-by":"publisher","first-page":"2187","DOI":"10.1093\/eurheartj\/ehad139","article-title":"Tc-99m labelled bone scintigraphy in suspected cardiac amyloidosis","volume":"44","author":"Rauf","year":"2023","journal-title":"Eur Heart J"},{"key":"2025102119532950900_ehaf387-B14","doi-asserted-by":"publisher","first-page":"1906","DOI":"10.2967\/jnumed.122.264041","article-title":"Prevalence and outcomes of cardiac amyloidosis in all-comer referrals for bone scintigraphy","volume":"63","author":"Nitsche","year":"2022","journal-title":"J Nucl Med"},{"key":"2025102119532950900_ehaf387-B15","doi-asserted-by":"publisher","first-page":"2726","DOI":"10.1038\/s41467-021-22877-8","article-title":"Artificial intelligence-enabled fully automated detection of cardiac amyloidosis using electrocardiograms and echocardiograms","volume":"12","author":"Goto","year":"2021","journal-title":"Nat Commun"},{"key":"2025102119532950900_ehaf387-B16","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1001\/jamacardio.2021.6059","article-title":"High-throughput precision phenotyping of left ventricular hypertrophy with cardiovascular deep learning","volume":"7","author":"Duffy","year":"2022","journal-title":"JAMA Cardiol"},{"key":"2025102119532950900_ehaf387-B17","doi-asserted-by":"publisher","first-page":"100452","DOI":"10.1016\/j.jacadv.2023.100452","article-title":"Automated echocardiographic detection of heart failure with preserved ejection fraction using artificial intelligence","volume":"2","author":"Akerman","year":"2023","journal-title":"JACC Adv"},{"key":"2025102119532950900_ehaf387-B18","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1016\/j.jcmg.2024.05.003","article-title":"Cardiac damage in early aortic stenosis: is the valve to blame?","volume":"17","author":"Dahl","year":"2024","journal-title":"JACC Cardiovasc Imaging"},{"key":"2025102119532950900_ehaf387-B19","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1001\/jamacardio.2021.3070","article-title":"Prevalence of transthyretin amyloid cardiomyopathy in heart failure with preserved ejection fraction","volume":"6","author":"AbouEzzeddine","year":"2021","journal-title":"JAMA Cardiol"},{"key":"2025102119532950900_ehaf387-B20","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1007\/s12350-018-1362-0","article-title":"Tc-99m pyrophosphate imaging for transthyretin cardiac amyloidosis: importance of estimation of cancer risk with the modality","volume":"27","author":"Pandey","year":"2020","journal-title":"J Nucl Cardiol"},{"key":"2025102119532950900_ehaf387-B21","doi-asserted-by":"publisher","first-page":"859310","DOI":"10.3389\/fcvm.2022.859310","article-title":"Fairness in cardiac magnetic resonance imaging: assessing sex and racial bias in deep learning-based segmentation","volume":"9","author":"Puyol-Ant\u00f3n","year":"2022","journal-title":"Front Cardiovasc Med"},{"key":"2025102119532950900_ehaf387-B22","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1016\/j.echo.2022.04.005","article-title":"Future guidelines for artificial intelligence in echocardiography","volume":"35","author":"Tseng","year":"2022","journal-title":"J Am Soc Echocardiogr"},{"key":"2025102119532950900_ehaf387-B23","doi-asserted-by":"publisher","first-page":"1533","DOI":"10.1016\/j.cardfail.2024.02.010","article-title":"Unmasking HFpEF with artificial intelligence: a disruptive opportunity for disease detection","volume":"30","author":"Karnik","year":"2024","journal-title":"J Card Fail"},{"key":"2025102119532950900_ehaf387-B24","doi-asserted-by":"publisher","first-page":"768847","DOI":"10.3389\/fcvm.2022.768847","article-title":"Automatic identification of patients with unexplained left ventricular hypertrophy in electronic health record data to improve targeted treatment and family screening","volume":"9","author":"Sammani","year":"2022","journal-title":"Front Cardiovasc Med"},{"key":"2025102119532950900_ehaf387-B25","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1186\/s12968-020-00690-4","article-title":"Deep learning to diagnose cardiac amyloidosis from cardiovascular magnetic resonance","volume":"22","author":"Martini","year":"2020","journal-title":"J Cardiovasc Magn Reson"},{"key":"2025102119532950900_ehaf387-B26","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.jchf.2013.11.004","article-title":"Left ventricular amyloid deposition in patients with heart failure and preserved ejection fraction","volume":"2","author":"Mohammed","year":"2014","journal-title":"JACC Heart Fail"},{"key":"2025102119532950900_ehaf387-B27","doi-asserted-by":"publisher","first-page":"2585","DOI":"10.1093\/eurheartj\/ehv338","article-title":"Wild-type transthyretin amyloidosis as a cause of heart failure with preserved ejection fraction","volume":"36","author":"Gonz\u00e1lez-L\u00f3pez","year":"2015","journal-title":"Eur Heart J"},{"key":"2025102119532950900_ehaf387-B28","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1016\/j.jchf.2020.04.007","article-title":"Endomyocardial biopsy characterization of heart failure with preserved ejection fraction and prevalence of cardiac amyloidosis","volume":"8","author":"Hahn","year":"2020","journal-title":"JACC Heart Fail"},{"key":"2025102119532950900_ehaf387-B29","doi-asserted-by":"publisher","first-page":"2879","DOI":"10.1093\/eurheartj\/ehx350","article-title":"Unveiling transthyretin cardiac amyloidosis and its predictors among elderly patients with severe aortic stenosis undergoing transcatheter aortic valve replacement","volume":"38","author":"Castano","year":"2017","journal-title":"Eur Heart J"},{"key":"2025102119532950900_ehaf387-B30","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.jchf.2020.12.005","article-title":"The impact of patients with cardiac amyloidosis in HFpEF trials","volume":"9","author":"Oghina","year":"2021","journal-title":"JACC Heart Fail"},{"key":"2025102119532950900_ehaf387-B31","doi-asserted-by":"publisher","first-page":"232","DOI":"10.4065\/mcp.2009.0547","article-title":"Clinical features and treatment response of light chain (AL) amyloidosis diagnosed in patients with previous diagnosis of multiple myeloma","volume":"85","author":"Madan","year":"2010","journal-title":"Mayo Clin Proc"}],"container-title":["European Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/eurheartj\/advance-article-pdf\/doi\/10.1093\/eurheartj\/ehaf387\/63700588\/ehaf387.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eurheartj\/advance-article-pdf\/doi\/10.1093\/eurheartj\/ehaf387\/63700588\/ehaf387.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T23:53:35Z","timestamp":1761090815000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eurheartj\/article\/46\/40\/4090\/8193027"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,9]]},"references-count":31,"journal-issue":{"issue":"40","published-online":{"date-parts":[[2025,7,9]]},"published-print":{"date-parts":[[2025,10,22]]}},"URL":"https:\/\/doi.org\/10.1093\/eurheartj\/ehaf387","relation":{},"ISSN":["0195-668X","1522-9645"],"issn-type":[{"value":"0195-668X","type":"print"},{"value":"1522-9645","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,10,21]]},"published":{"date-parts":[[2025,7,9]]}}}