{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T10:36:41Z","timestamp":1793702201431,"version":"4.5.1"},"reference-count":92,"publisher":"Oxford University Press (OUP)","issue":"43","license":[{"start":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T00:00:00Z","timestamp":1756857600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Genetic family screening following the detection of a pathogenic or likely pathogenic variant in a proband with dilated cardiomyopathy (DCM) remains one of the main applications of genetic testing. While cardiac screening is recommended for all first-degree relatives, the a priori risk among family members varies. Consequently, screening regimens should be tailored according to both genetic and clinical information at the individual and familial level. This clinical consensus statement provides tools to help with the risk assessment and follow-up of screening for family members and discusses the utility for integration of genotype-specific information, cardiac imaging, and electrocardiogram findings to personalize cardiac screening regimens, which in conjunction will likely improve individualized risk prediction. Early phenotypic detection of DCM in family members remains an active area of research and innovation. In addition, data are starting to accrue on the utility of early therapeutic intervention in family members with very mild phenotypes that may inform future management in addition to screening. A systematic strategy is proposed to determine the a priori risk of developing DCM for a family member, and the potential of integrating genotype\u2013phenotype knowledge towards family management. Lastly, there is a focus on the current knowledge gaps and ongoing and future opportunities to improve risk prediction, early disease detection, and treatment of family members of patients with DCM.<\/jats:p>","DOI":"10.1093\/eurheartj\/ehaf571","type":"journal-article","created":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T11:16:55Z","timestamp":1753096615000},"page":"4569-4582","source":"Crossref","is-referenced-by-count":16,"title":["Clinical care of family members of patients with dilated cardiomyopathy"],"prefix":"10.1093","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5549-1298","authenticated-orcid":false,"given":"Job A J","family":"Verdonschot","sequence":"first","affiliation":[{"name":"Department of Clinical Genetics, Maastricht University Medical Center+ , P. Debyelaan 25, 6229HX Maastricht ,","place":["The Netherlands"]},{"name":"Department of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University , Universiteitssingel 50, 6229 ER Maastricht ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0014-9927","authenticated-orcid":false,"given":"Juan Pablo","family":"Kaski","sequence":"additional","affiliation":[{"name":"Centre for Paediatric Inherited and Rare Cardiovascular Disease, Institute of Cardiovascular Science, University College London , London ,","place":["UK"]},{"name":"Centre for Inherited Cardiovascular Diseases, Great Ormond Street Hospital , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Folkert W","family":"Asselbergs","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centre, University of Amsterdam , Amsterdam ,","place":["The Netherlands"]},{"name":"Institute of Health Informatics, University College London , London ,","place":["UK"]},{"name":"The National Institute for Health Research University College London Hospitals Biomedical Research Centre, University College London , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elijah R","family":"Behr","sequence":"additional","affiliation":[{"name":"Cardiovascular and GEbonics Research Institute, City St. George\u2019s, University of London , London ,","place":["UK"]},{"name":"Cardiovascular Clinical Academic Group, St. George\u2019s University Hospitals NHS Foundation Trust , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Charron","sequence":"additional","affiliation":[{"name":"Fili\u00e8re Nationale de Sant\u00e9 CARDIOGEN , Paris ,","place":["France"]},{"name":"Genetics and Cardiology Departments, APHP, Sorbonne Universit\u00e9, 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