{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:47:34Z","timestamp":1790084854187,"version":"4.0.1"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"47","license":[{"start":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T00:00:00Z","timestamp":1756512000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100012774","name":"Innovation Fund Denmark","doi-asserted-by":"publisher","award":["12-135225"],"award-info":[{"award-number":["12-135225"]}],"id":[{"id":"10.13039\/100012774","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005275","name":"Capital Region of Denmark","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005275","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007405","name":"Danish Heart Foundation","doi-asserted-by":"publisher","award":["11-04-R83-A3363-22625"],"award-info":[{"award-number":["11-04-R83-A3363-22625"]}],"id":[{"id":"10.13039\/100007405","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Aalborg University Talent Management Programme"},{"DOI":"10.13039\/100007460","name":"Arvid Nilssons Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007460","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008276","name":"Skibsreder Per Henriksen, R. og Hustrus Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008276","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]},{"name":"European Union\u2019s Horizon 2020 research and innovation program","award":["847770"],"award-info":[{"award-number":["847770"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Potassium levels influence cardiac electrophysiology, yet their day-to-day association with atrial fibrillation (AF) remains unclear. This study investigated the association between plasma potassium (p-potassium) and daily AF in at-risk individuals undergoing continuous electrocardiographic monitoring.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a post hoc analysis of the LOOP study randomizing participants with stroke risk factors to implantable loop recorder (ILR) screening for AF (n = 1501) or usual care. The ILR raw data were linked to p-potassium measurements collected in routine care allowing for 1-day time difference. Associations between p-potassium and daily AF &amp;gt; 60\u2005min (main outcome) were analysed using generalized and linear mixed effect models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The ILR data and blood tests results were available for 1334 participants combining &amp;gt;1.6 million days of heart rhythm monitoring (including 50 746 days with AF) with 12 136 p-potassium measurements. P-potassium was lower on days with AF [mean difference \u2212.21\u2005mmol\/L (\u2212.25; \u2212.18)]. Self-controlled case analyses comparing AF incidence during hypokalaemia (p-potassium &amp;lt;3.5\u2005mmol\/L) vs in normal range yielded an incidence rate ratio of 2.24 (1.29\u20133.88). Hypokalaemia was present in 5.1% of days with AF lasting &amp;lt;60\u2005min and 19.1% with AF lasting &amp;gt;240\u2005min. Each mmol\/L decrease in p-potassium was associated with a five-fold increase in odds of AF [adjusted odds ratio (aOR) .20 (.15\u2013.28)], more strongly when p-potassium deviated from the individual\u2019s usual value [aOR .15 (.10\u2013.24); P-interaction = .001], and less in participants receiving diuretics [aOR .28 (.17\u2013.47); P-interaction &amp;lt; .0001].<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This exploratory study found that low p-potassium was associated with day-to-day AF occurrence, particularly for longer episodes and when deviating from the individual\u2019s usual level.<\/jats:p>\n                  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