{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T03:38:42Z","timestamp":1793417922327,"version":"4.5.0"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T00:00:00Z","timestamp":1759795200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017415","name":"Peking University First Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017415","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National High-Level Hospital Clinical Research Funding"},{"name":"High Quality Clinical Research Project of Peking University First Hospital","award":["2022CR77"],"award-info":[{"award-number":["2022CR77"]}]},{"name":"Research Achievement Transformation Project of Peking University First Hospital","award":["2022CX07"],"award-info":[{"award-number":["2022CX07"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>The optimal therapy for patients with atherosclerotic renal artery stenosis (ARAS) remains unresolved. This study compared the efficacy of renal fractional flow reserve (FFR)-guided revascularization and traditional angiography-guided revascularization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In total, 101 patients with ARAS and hypertension were randomly assigned to either the FFR-guided or angiography-guided group (ClinicalTrials.gov identifier: NCT05732077). Stenting was performed in the angiography-guided group regardless of FFR, whereas stenting was only performed in the FFR-guided group for patients with FFR &amp;lt; 0.80. The primary endpoints were the percentage changes in ambulatory daytime mean systolic blood pressure (DMSBP) and composite index of antihypertensive medicines (CIAHM) after 3 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The percentage changes in DMSBP (4% [\u22122%, 11%] vs 4% [\u22123%, 10%]; P = .97) and CIAHM (0% [0%, 3%] vs 1% [0%, 4%]; P = .33) did not differ between groups. However, the rate of stenting was significantly lower in the FFR-guided group (46.0% vs 100.0%, P &amp;lt; .01). Moreover, compared with the findings in patients with FFR \u2265 0.80 who did not receive stenting, stenting was beneficial in patients with FFR &amp;lt; 0.80 (adjusted mean DMSBP reduction, 6.2 [95% confidence interval {CI}, 0.6\u201311.9] mmHg; mean CIAHM reduction, 3.1 [95% CI, 1.5\u20134.7]), but not in those with FFR \u2265 0.80 (1.4 [95% CI, \u22124.5\u20137.2] mmHg, and 0.7 [95% CI, \u22121.1\u20132.5], respectively).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>FFR-guided revascularization significantly reduced unnecessary stenting compared with angiography-guided revascularization. Both blood pressure and antihypertensive medication usage decreased significantly after stenting in patients with FFR &amp;lt; 0.80.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurheartj\/ehaf746","type":"journal-article","created":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T11:29:37Z","timestamp":1757417377000},"page":"761-769","source":"Crossref","is-referenced-by-count":18,"title":["Fractional flow reserve-guided renal artery stenting in atherosclerotic renovascular hypertension: the FAIR randomized trial"],"prefix":"10.1093","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1556-598X","authenticated-orcid":false,"given":"Yuxi","family":"Li","sequence":"first","affiliation":[{"name":"Department of Cardiology, Peking University First Hospital , Xishiku 8, Beijing 100034 ,","place":["China"]},{"name":"Institute of Cardiovascular Disease, Peking University First Hospital , Xishiku 8, Beijing 100034 ,","place":["China"]},{"name":"Hypertension 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