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Many aspects of this problem remain unknown and underexplored, with clinical practice guidelines providing limited information on guidance for its causative diagnosis, prevention and management. This review article aims to provide a contemporary perspective on the problem of post-PCI angina, leveraging recent advancements on the pathophysiological mechanisms that frequently underlie this condition, including sub-optimal functional results of PCI and non-obstructive causes of myocardial ischaemia. The opportunities provided by new functional coronary angiography tools are explored. A practical structured approach to the aetiological diagnosis and treatment of these patients is proposed.<\/jats:p>","DOI":"10.1093\/eurheartj\/ehaf771","type":"journal-article","created":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T12:13:58Z","timestamp":1760616838000},"page":"408-422","source":"Crossref","is-referenced-by-count":8,"title":["Angina after percutaneous coronary interventions"],"prefix":"10.1093","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4045-2859","authenticated-orcid":false,"given":"Marco","family":"Lombardi","sequence":"first","affiliation":[{"name":"Department of Interventional Cardiology, Hospital Cl\u00ednico San Carlos IDISSC, Complutense University of Madrid and CIBER-CV , Calle del Prof Mart\u00edn Lagos, s\/n, Madrid 28040 ,","place":["Spain"]},{"name":"Department of Internal Medicine, University of Genova , Genova ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurie-Anne","family":"Boivin-Proulx","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology, Hospital Cl\u00ednico San Carlos IDISSC, Complutense University of Madrid and CIBER-CV , Calle del Prof Mart\u00edn Lagos, s\/n, Madrid 28040 ,","place":["Spain"]},{"name":"Department of Interventional Cardiology, University of Ottawa Heart Institute , Ottawa, Ontario ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Jer\u00f3nimo","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology, Hospital Cl\u00ednico San Carlos IDISSC, Complutense University of Madrid and CIBER-CV , Calle del Prof Mart\u00edn Lagos, s\/n, Madrid 28040 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hern\u00e1n","family":"Mej\u00eda-Renter\u00eda","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology, Hospital Cl\u00ednico San Carlos IDISSC, Complutense University of Madrid and CIBER-CV , Calle del Prof Mart\u00edn Lagos, s\/n, Madrid 28040 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3827-945X","authenticated-orcid":false,"given":"Nieves","family":"Gonzalo","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology, Hospital Cl\u00ednico San Carlos IDISSC, Complutense University of Madrid and CIBER-CV , Calle del Prof Mart\u00edn Lagos, s\/n, Madrid 28040 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2917-6707","authenticated-orcid":false,"given":"Tommaso","family":"Gori","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiology, University Medical Center Mainz , Mainz ,","place":["Germany"]},{"name":"German Centre for Cardiovascular Research (DZHK), Partnersite RheinMain , Mainz ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roxana","family":"Mehran","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology, The Zena and Michael A. 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