{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T10:18:27Z","timestamp":1775125107567,"version":"3.50.1"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"42","license":[{"start":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T00:00:00Z","timestamp":1762473600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,7]]},"DOI":"10.1093\/eurheartj\/ehaf847","type":"journal-article","created":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T07:42:53Z","timestamp":1762674173000},"page":"4347-4350","source":"Crossref","is-referenced-by-count":2,"title":["Focus on trials: primary prevention, ischaemic heart disease, atrial fibrillation, and obstructive sleep apnoea"],"prefix":"10.1093","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9482-411X","authenticated-orcid":false,"given":"Filippo","family":"Crea","sequence":"first","affiliation":[{"name":"Center of Excellence of Cardiovascular Sciences, Ospedale Isola Tiberina \u2013 Gemelli Isola , Rome ,","place":["Italy"]},{"name":"Catholic University of the Sacred Heart , Rome ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,11,7]]},"reference":[{"key":"2025110902424661300_ehaf847-B1","doi-asserted-by":"publisher","first-page":"4359","DOI":"10.1093\/eurheartj\/ehaf190","article-title":"Focused Update of the 2019 ESC\/EAS Guidelines for the management of dyslipidaemias","volume":"46","author":"Mach","year":"2025","journal-title":"Eur Heart J"},{"key":"2025110902424661300_ehaf847-B2","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.1093\/eurheartj\/ehae613","article-title":"Cardiovascular outcomes with semaglutide by severity of chronic kidney disease in type 2 diabetes: the FLOW trial","volume":"46","author":"Mahaffey","year":"2025","journal-title":"Eur Heart J"},{"key":"2025110902424661300_ehaf847-B3","doi-asserted-by":"publisher","first-page":"2752","DOI":"10.1093\/eurheartj\/ehae288","article-title":"Incident heart failure in chronic kidney disease: proteomics informs biology and risk stratification","volume":"45","author":"Dubin","year":"2024","journal-title":"Eur Heart J"},{"key":"2025110902424661300_ehaf847-B4","doi-asserted-by":"publisher","first-page":"2095","DOI":"10.1093\/eurheartj\/ehad115","article-title":"Proteomic cardiovascular risk assessment in chronic kidney disease","volume":"44","author":"Deo","year":"2023","journal-title":"Eur Heart J"},{"key":"2025110902424661300_ehaf847-B5","doi-asserted-by":"publisher","first-page":"4379","DOI":"10.1093\/eurheartj\/ehaf591","article-title":"Decline in glomerular filtration rate as an endpoint in heart failure clinical trials: challenges and solutions","volume":"46","author":"Inker","year":"2025","journal-title":"Eur Heart J"},{"key":"2025110902424661300_ehaf847-B6","doi-asserted-by":"publisher","first-page":"4396","DOI":"10.1093\/eurheartj\/ehaf580","article-title":"Coronary function testing vs angiography alone to guide treatment of angina with non-obstructive coronary arteries: the ILIAS ANOCA trial","volume":"46","author":"Boerhout","year":"2025","journal-title":"Eur Heart J"},{"key":"2025110902424661300_ehaf847-B7","doi-asserted-by":"publisher","first-page":"4407","DOI":"10.1093\/eurheartj\/ehaf692","article-title":"Angina with non-obstructive coronary arteries: a success story","volume":"46","author":"Montone","year":"2025","journal-title":"Eur Heart J"},{"key":"2025110902424661300_ehaf847-B8","doi-asserted-by":"publisher","first-page":"5042","DOI":"10.1093\/eurheartj\/ehae617","article-title":"Aspirin vs. clopidogrel monotherapy after percutaneous coronary intervention: 1-year follow-up of the STOPDAPT-3 trial","volume":"45","author":"Watanabe","year":"2024","journal-title":"Eur Heart J"},{"key":"2025110902424661300_ehaf847-B9","doi-asserted-by":"publisher","first-page":"3542","DOI":"10.1093\/eurheartj\/ehac309","article-title":"Rivaroxaban and aspirin vs. aspirin alone in Asian compared with non-Asian patients with chronic coronary artery disease or peripheral arterial disease: the COMPASS trial","volume":"43","author":"Hori","year":"2022","journal-title":"Eur Heart J"},{"key":"2025110902424661300_ehaf847-B10","doi-asserted-by":"publisher","first-page":"4410","DOI":"10.1093\/eurheartj\/ehaf514","article-title":"Aspirin, cardiovascular events, and major bleeding in older adults: extended follow-up of the ASPREE trial","volume":"46","author":"Wolfe","year":"2025","journal-title":"Eur Heart J"},{"key":"2025110902424661300_ehaf847-B11","doi-asserted-by":"publisher","first-page":"4423","DOI":"10.1093\/eurheartj\/ehaf642","article-title":"Estimating the long-term effects of aspirin for primary prevention","volume":"46","author":"Baigent","year":"2025","journal-title":"Eur Heart J"},{"key":"2025110902424661300_ehaf847-B12","doi-asserted-by":"publisher","first-page":"4873","DOI":"10.1093\/eurheartj\/ehae826","article-title":"Focus on atrial fibrillation: role of atrioventricular node ablation, prediction by deep learning, and anticoagulation in device-detected arrhythmia","volume":"45","author":"Crea","year":"2024","journal-title":"Eur Heart J"},{"key":"2025110902424661300_ehaf847-B13","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1093\/eurheartj\/ehae832","article-title":"Ablation of persistent atrial fibrillation: lessons learnt from the CAPLA trial","volume":"46","author":"Koneru","year":"2025","journal-title":"Eur Heart J"},{"key":"2025110902424661300_ehaf847-B14","doi-asserted-by":"publisher","first-page":"4887","DOI":"10.1093\/eurheartj\/ehae656","article-title":"Atrioventricular node ablation for atrial fibrillation in the era of conduction system pacing","volume":"45","author":"Joza","year":"2024","journal-title":"Eur Heart J"},{"key":"2025110902424661300_ehaf847-B15","doi-asserted-by":"publisher","first-page":"4383","DOI":"10.1093\/eurheartj\/ehae618","article-title":"Catheter ablation for atrial fibrillation: indications and future perspective","volume":"45","author":"Natale","year":"2024","journal-title":"Eur Heart J"},{"key":"2025110902424661300_ehaf847-B16","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1093\/eurheartj\/ehae580","article-title":"Radiofrequency catheter ablation of persistent atrial fibrillation by pulmonary vein isolation with or without left atrial posterior wall isolation: long-term outcomes of the CAPLA trial","volume":"46","author":"William","year":"2025","journal-title":"Eur Heart J"},{"key":"2025110902424661300_ehaf847-B17","doi-asserted-by":"publisher","first-page":"4305","DOI":"10.1093\/eurheartj\/ehae532","article-title":"Atrial tachyarrhythmia prevention by Shensong Yangxin after catheter ablation for persistent atrial fibrillation: the SS-AFRF trial","volume":"45","author":"Huang","year":"2024","journal-title":"Eur Heart J"},{"key":"2025110902424661300_ehaf847-B18","doi-asserted-by":"publisher","first-page":"2617","DOI":"10.1093\/eurheartj\/ehae374","article-title":"Ablation of persistent atrial fibrillation: never say never again","volume":"45","author":"Samuel","year":"2024","journal-title":"Eur Heart J"},{"key":"2025110902424661300_ehaf847-B19","doi-asserted-by":"publisher","first-page":"2604","DOI":"10.1093\/eurheartj\/ehae291","article-title":"Catheter ablation for persistent atrial fibrillation: patterns of recurrence and impact on quality of life and health care utilization","volume":"45","author":"Crowley","year":"2024","journal-title":"Eur Heart J"},{"key":"2025110902424661300_ehaf847-B20","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1093\/eurheartj\/ehad872","article-title":"Deciphering connections: how is cryoablation interlinking with disease progression in atrial fibrillation ablation?","volume":"45","author":"Younes","year":"2024","journal-title":"Eur Heart J"},{"key":"2025110902424661300_ehaf847-B21","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1093\/eurheartj\/ehad572","article-title":"Atrial fibrillation progression after cryoablation vs. radiofrequency ablation: the CIRCA-DOSE trial","volume":"45","author":"Andrade","year":"2024","journal-title":"Eur Heart J"},{"key":"2025110902424661300_ehaf847-B22","doi-asserted-by":"publisher","first-page":"4426","DOI":"10.1093\/eurheartj\/ehaf451","article-title":"Cryoballoon vs radiofrequency ablation in persistent atrial fibrillation: the CRRF-PeAF trial","volume":"46","author":"Miyamoto","year":"2025","journal-title":"Eur Heart J"},{"key":"2025110902424661300_ehaf847-B23","doi-asserted-by":"publisher","first-page":"4438","DOI":"10.1093\/eurheartj\/ehaf557","article-title":"Is atrial remodelling after atrial fibrillation catheter ablation clinically relevant?","volume":"46","author":"Andrade","year":"2025","journal-title":"Eur Heart J"},{"key":"2025110902424661300_ehaf847-B24","doi-asserted-by":"publisher","first-page":"4441","DOI":"10.1093\/eurheartj\/ehaf648","article-title":"Acetazolamide effect on ambulatory blood pressure in patients with obstructive sleep apnoea living at high altitude: a randomized trial","volume":"46","author":"Tan","year":"2025","journal-title":"Eur Heart J"},{"key":"2025110902424661300_ehaf847-B25","doi-asserted-by":"publisher","first-page":"4444","DOI":"10.1093\/eurheartj\/ehaf638","article-title":"Can the effects of vagus nerve stimulation on improving motor function and inflammation be applied to the general healthy population?","volume":"46","author":"Lin","year":"2025","journal-title":"Eur Heart J"},{"key":"2025110902424661300_ehaf847-B26","doi-asserted-by":"publisher","first-page":"1634","DOI":"10.1093\/eurheartj\/ehaf037","article-title":"Gutierrez Del Arroyo A, Thirugnanasambanthar J, Ravindran JI","volume":"46","author":"Ackland","year":"2025","journal-title":"Non-invasive vagus nerve stimulation and exercise capacity in healthy volunteers: a randomized trial. Eur Heart J"}],"container-title":["European Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/eurheartj\/article-pdf\/46\/42\/4347\/65237415\/ehaf847.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eurheartj\/article-pdf\/46\/42\/4347\/65237415\/ehaf847.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T07:42:53Z","timestamp":1762674173000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eurheartj\/article\/46\/42\/4347\/8316209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,7]]},"references-count":26,"journal-issue":{"issue":"42","published-online":{"date-parts":[[2025,11,7]]},"published-print":{"date-parts":[[2025,11,7]]}},"URL":"https:\/\/doi.org\/10.1093\/eurheartj\/ehaf847","relation":{},"ISSN":["0195-668X","1522-9645"],"issn-type":[{"value":"0195-668X","type":"print"},{"value":"1522-9645","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,11,7]]},"published":{"date-parts":[[2025,11,7]]}}}