{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T01:32:10Z","timestamp":1793410330611,"version":"4.5.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"24","license":[{"start":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:00:00Z","timestamp":1772755200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Patients with LMNA gene variants are at high risk for dilated cardiomyopathy and heart failure (HF), but no prediction model for severe HF events exists. This study aimed to describe the incidence of severe HF events and develop a prediction model in a large cohort of patients with adult-onset laminopathies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>From a population of 660 patients enrolled in the French LMNA nationwide registry, 470 adults were included in the derivation cohort. An independent international validation cohort included 245 additional patients. Baseline characteristics at genetic testing were assessed and the cumulative incidence of the primary endpoint HF-major adverse cardiac events (HF-MACE) was calculated, defined as HF hospitalization, HF-related death, mechanical circulatory support, or heart transplantation. Predictors of HF-MACE were studied after excluding patients with left ventricular ejection fraction (LVEF) &amp;lt;30% at baseline using a Fine-Gray competing risk model, adjusted hazard ratio (aHR) with 95% confidence interval (CI), and Harrell\u2019s concordance (C-) index. A secondary composite endpoint, without hospitalization, was also studied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 470 patients of the derivation cohort, HF-MACE occurred in 65 over a median follow-up of 7.1 years (interquartile range: 3.4\u201312.1). Four independent predictors of HF-MACE were identified: male sex (aHR 1.86; 95% CI 1.060\u20133.290), LVEF &amp;lt;50% (aHR 2.18; 95% CI 1.080\u20134.400), missense variants in head and rod domains (aHR 2.91; 95% CI 1.110\u20137.630), and complete left bundle branch block (aHR 2.99; 95% CI 1.400\u20136.400). The C-index of the model was 0.750 (95% CI 0.720\u20130.780) in the derivation cohort and 0.758 (95% CI 0.720\u20130.800) in the validation cohort. The 5-year cumulative incidence of HF-MACE was 1.5% (95% CI 0.6\u20133.6), 5.0% (95% CI 1.8\u20138.2), and 22.0% (95% CI 15.6\u201328.4) among patients with 0, 1, and \u22652 risk factors, respectively. In patients with LVEF &amp;lt;30% at baseline, the 1-year incidence of HF-MACE was 50%, and those patients were excluded from the risk score.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The first prediction model for severe HF events in adult laminopathies was developed, which may facilitate early and optimal preventive management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical trial registration<\/jats:title>\n                    <jats:p>URL: https:\/\/www.clinicaltrials.gov Unique identifier: NCT03058185.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurheartj\/ehag104","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T12:23:41Z","timestamp":1770035021000},"page":"3135-3148","source":"Crossref","is-referenced-by-count":6,"title":["Laminopathies: natural history and risk prediction of heart failure"],"prefix":"10.1093","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1782-1118","authenticated-orcid":false,"given":"Philippe","family":"Charron","sequence":"first","affiliation":[{"name":"Sorbonne University, APHP, Department of Genetics, Centre de R\u00e9f\u00e9rence des Maladies Cardiaques H\u00e9r\u00e9ditaires ou rares, INSERM UMRS 1166, Institute of Cardiometabolism and Nutrition (ICAN), Piti\u00e9-Salp\u00eatri\u00e8re Hospital , 47 bvd de l'H\u00f4pital, Paris 75013 ,","place":["France"]},{"name":"APHP, Department of Cardiology, Piti\u00e9-Salp\u00eatri\u00e8re Hospital , 47 bvd de l'H\u00f4pital, 75013 Paris ,","place":["France"]},{"name":"ACTION Study Group, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, 47 bvd de l'H\u00f4pital, 75013 \u00a0 Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8483-8323","authenticated-orcid":false,"given":"Julie","family":"Proukhnitzky","sequence":"additional","affiliation":[{"name":"Sorbonne University, APHP, Department of Genetics, Centre de R\u00e9f\u00e9rence des Maladies Cardiaques H\u00e9r\u00e9ditaires ou rares, INSERM UMRS 1166, Institute of Cardiometabolism and Nutrition (ICAN), Piti\u00e9-Salp\u00eatri\u00e8re Hospital , 47 bvd de l'H\u00f4pital, Paris 75013 ,","place":["France"]},{"name":"APHP, Department of Cardiology, Piti\u00e9-Salp\u00eatri\u00e8re Hospital , 47 bvd de l'H\u00f4pital, 75013 Paris ,","place":["France"]},{"name":"ACTION Study Group, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, 47 bvd de l'H\u00f4pital, 75013 \u00a0 Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rabah","family":"Ben Yaou","sequence":"additional","affiliation":[{"name":"APHP, Centre de r\u00e9f\u00e9rence des maladies neuromusculaires Nord\/Est\/Ile de France, FILNEMUS, Myology Institute, Neuromyology Department, Piti\u00e9-Salp\u00eatri\u00e8re Hospital , Paris ,","place":["France"]},{"name":"Centre de Recherche en Myologie, Sorbonne Universit\u00e9, INSERM, Institut de Myologie , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale","family":"Richard","sequence":"additional","affiliation":[{"name":"APHP, UF Cardiog\u00e9n\u00e9tique et Myog\u00e9n\u00e9tique mol\u00e9culaire et cellulaire, Centre de G\u00e9n\u00e9tique, INSERM UMRS 1166, ICAN, GH Piti\u00e9 Salp\u00eatri\u00e8re , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Demb\u00e9l\u00e9","sequence":"additional","affiliation":[{"name":"D\u00e9partement Data Sant\u00e9 et Recherche M\u00e9dicale, AFM-T\u00e9l\u00e9thon, Direction des Op\u00e9rations et Innovations Scientifiques , Evry ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Urtis","sequence":"additional","affiliation":[{"name":"Scientific Department, Centre for Inherited Cardiovascular Diseases, Fondazione IRCCS Policlinico San Matteo , Pavia ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Gossios","sequence":"additional","affiliation":[{"name":"Centre for Heart Muscle Disease, Institute of Cardiovascular Science, University College London & St.Bartholomew\u2019s Hospital , London ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saurabh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Westmead Hospital, Westmead Applied Research Centre, University of Sydney Westmead ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1966-1880","authenticated-orcid":false,"given":"Konstantinos","family":"Savvatis","sequence":"additional","affiliation":[{"name":"Centre for Heart Muscle Disease, Institute of Cardiovascular Science, University College London & St.Bartholomew\u2019s Hospital , London ,","place":["United Kingdom"]},{"name":"NIHR Barts Biomedical Research Centre, Barts Heart Centre , London ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanya","family":"Stojkovic","sequence":"additional","affiliation":[{"name":"APHP, Centre de r\u00e9f\u00e9rence des maladies neuromusculaires Nord\/Est\/Ile de France, FILNEMUS, Myology Institute, Neuromyology Department, Piti\u00e9-Salp\u00eatri\u00e8re Hospital , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Anselme","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Normandie Univ, UNIROUEN, U1096, CHU Rouen , Rouen ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Maury","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Toulouse, I2MC, INSERM UMR 1297 , Toulouse ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4846-5021","authenticated-orcid":false,"given":"Estelle","family":"Gandjbakhch","sequence":"additional","affiliation":[{"name":"Sorbonne University, APHP, Department of Genetics, Centre de R\u00e9f\u00e9rence des Maladies Cardiaques H\u00e9r\u00e9ditaires ou rares, INSERM UMRS 1166, Institute of Cardiometabolism and Nutrition (ICAN), Piti\u00e9-Salp\u00eatri\u00e8re Hospital , 47 bvd de l'H\u00f4pital, Paris 75013 ,","place":["France"]},{"name":"APHP, Department of Cardiology, Piti\u00e9-Salp\u00eatri\u00e8re Hospital , 47 bvd de l'H\u00f4pital, 75013 Paris ,","place":["France"]},{"name":"ACTION Study Group, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, 47 bvd de l'H\u00f4pital, 75013 \u00a0 Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rapha\u00ebl","family":"Martins","sequence":"additional","affiliation":[{"name":"Univ Rennes, CHU Rennes, Inserm, LTSI\u2014UMR 1099 Cardiology Department, , Rennes ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8348-9320","authenticated-orcid":false,"given":"Fr\u00e9d\u00e9ric","family":"Sacher","sequence":"additional","affiliation":[{"name":"Centre de reference des maladies rythmiques h\u00e9r\u00e9ditaires, Bordeaux University Hospital (CHU), IHU Liryc, Electrophysiology and Heart Modeling Institute, fondation Bordeaux Universit\u00e9, Univ. Bordeaux, INSERM U1045 , Bordeaux ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4742-281X","authenticated-orcid":false,"given":"Jean-Noel","family":"Trochu","sequence":"additional","affiliation":[{"name":"Centre de r\u00e9f\u00e9rence des cardiomyopathies, Nantes Universit\u00e9, CHU Nantes, INSERM 1087, CIC 1413, l'institut du thorax , Nantes ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Rouanet","sequence":"additional","affiliation":[{"name":"ACTION Study Group, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, 47 bvd de l'H\u00f4pital, 75013 \u00a0 Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Lejeune","sequence":"additional","affiliation":[{"name":"D\u00e9partement Data Sant\u00e9 et Recherche M\u00e9dicale, AFM-T\u00e9l\u00e9thon, Direction des Op\u00e9rations et Innovations Scientifiques , Evry ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8345-0845","authenticated-orcid":false,"given":"Ghassan","family":"Moubarak","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology and Pacing, Clinique Ambroise Par\u00e9 , Neuilly-sur-Seine ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdallah","family":"Fayssoil","sequence":"additional","affiliation":[{"name":"APHP, Service de Neurologie, Centre de R\u00e9f\u00e9rence des maladies neuromusculaires Nord\/Est\/\u00cele de France, Universit\u00e9 Paris-Saclay, UVSQ, INSERM U1179, H\u00f4pital Raymond Poincar\u00e9 , Garches ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eloi","family":"Marijon","sequence":"additional","affiliation":[{"name":"Division of Cardiology, European Georges Pompidou Hospital , Paris ,","place":["France"]},{"name":"Paris Cardiovascular Research Center, Universit\u00e9 Paris Cit\u00e9, 56 Rue Leblanc , 75015 Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Lafor\u00eat","sequence":"additional","affiliation":[{"name":"APHP, Service de Neurologie, Centre de R\u00e9f\u00e9rence des maladies neuromusculaires Nord\/Est\/\u00cele de France, Universit\u00e9 Paris-Saclay, UVSQ, INSERM U1179, H\u00f4pital Raymond Poincar\u00e9 , Garches ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"B\u00e9hin","sequence":"additional","affiliation":[{"name":"APHP, Centre de r\u00e9f\u00e9rence des maladies neuromusculaires Nord\/Est\/Ile de France, FILNEMUS, Myology Institute, Neuromyology Department, Piti\u00e9-Salp\u00eatri\u00e8re Hospital , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Leonard-Louis","sequence":"additional","affiliation":[{"name":"APHP, Centre de r\u00e9f\u00e9rence des maladies neuromusculaires Nord\/Est\/Ile de France, FILNEMUS, Myology Institute, Neuromyology Department, Piti\u00e9-Salp\u00eatri\u00e8re Hospital , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilhem","family":"Sole","sequence":"additional","affiliation":[{"name":"Centre de r\u00e9f\u00e9rence et service des maladies neuromusculaires AOC, FILNEMUS, EURONMD, CHU de Bordeaux , Bordeaux ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabien","family":"Labombarda","sequence":"additional","affiliation":[{"name":"Cardiology Department, University Hospital of Caen, UR 4650 Unicaen , Caen ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinne","family":"Metay","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Myologie, Sorbonne Universit\u00e9, INSERM, Institut de Myologie , Paris ,","place":["France"]},{"name":"APHP, UF Cardiog\u00e9n\u00e9tique et Myog\u00e9n\u00e9tique mol\u00e9culaire et cellulaire, Centre de G\u00e9n\u00e9tique, INSERM UMRS 1166, ICAN, GH Piti\u00e9 Salp\u00eatri\u00e8re , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Quijano-Roy","sequence":"additional","affiliation":[{"name":"APHP, Centre de r\u00e9f\u00e9rence des maladies neuromusculaires Nord\/Est\/Ile de France, Unit\u00e9 Neuromusculaire Service de Neurop\u00e9diatrie, R\u00e9animation et R\u00e9education Pediatriques, H\u00f4pital Raymond Poincar\u00e9, Garches, UMR 1179 INSERM, Universit\u00e9 Versailles Saint-Quentin\u2013en-Yvelines , Montigny-le-Bretonneux ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2324-1208","authenticated-orcid":false,"given":"Ivana","family":"Dabaj","sequence":"additional","affiliation":[{"name":"Normandie Univ, UNIROUEN, CHU Rouen, AIMS, SysMedLab, Department of Neonatology, Pediatric Intensive Care and Neuropediatrics, Nord\/Est\/Ile de France Reference Center in Neuromuscular Diseases, CHU Rouen, FILNEMUS , Rouen ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Klug","sequence":"additional","affiliation":[{"name":"CHU Lille, Service de Cardiologie, Inserm U1167, Institut Pasteur de Lille, Univ. Lille , Lille ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3899-9983","authenticated-orcid":false,"given":"Gilbert","family":"Habib","sequence":"additional","affiliation":[{"name":"Department of Cardiology, La Timone Hospital, Aix-Marseille Universit\u00e9 , Marseille ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Christine","family":"Vantyghem","sequence":"additional","affiliation":[{"name":"CHU Lille, Endocrinology, Diabetology and Metabolism, Univ Lille, Inserm, UMR 1190 -Translational Research in Diabetes, EGID European Genomic Institute for Diabetes , Lille ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8185-2229","authenticated-orcid":false,"given":"Philippe","family":"Chevalier","sequence":"additional","affiliation":[{"name":"Service de Cardiologie, H\u00f4pital Est , Lyon ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Salort-Campana","sequence":"additional","affiliation":[{"name":"APHM, Centre de r\u00e9f\u00e9rence des maladies neuromusculaires PACA-R\u00e9union-Rh\u00f4ne Alpes, H\u00f4pital Timone, Aix Marseille Universit\u00e9, Inserm UMR_S 910, GMGF , Marseille ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1080-7425","authenticated-orcid":false,"given":"Jean-Marc","family":"Sellal","sequence":"additional","affiliation":[{"name":"D\u00e9partment de Cardiologie, Centre Hospitalier Universitaire de Nancy, INSERM-IADI U1254 , Vand\u0153uvre l\u00e8s-Nancy ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5391-4007","authenticated-orcid":false,"given":"Xavier","family":"Waintraub","sequence":"additional","affiliation":[{"name":"APHP, Department of Cardiology, Piti\u00e9-Salp\u00eatri\u00e8re Hospital , 47 bvd de l'H\u00f4pital, 75013 Paris ,","place":["France"]},{"name":"ACTION Study Group, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, 47 bvd de l'H\u00f4pital, 75013 \u00a0 Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6645-082X","authenticated-orcid":false,"given":"Katja","family":"Zeppenfeld","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Centre , Leiden ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1600-7907","authenticated-orcid":false,"given":"Ahmad S","family":"Amin","sequence":"additional","affiliation":[{"name":"Department of Experimental Cardiology, Amsterdam Cardiovascular Sciences, Heart Failure & Arrhythmias, Amsterdam University Medical Centers, location AMC, University of Amsterdam , Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daria R","family":"Kramarenko","sequence":"additional","affiliation":[{"name":"Department of Experimental Cardiology, Amsterdam Cardiovascular Sciences, Heart Failure & Arrhythmias, Amsterdam University Medical Centers, location AMC, University of Amsterdam , Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yigal M","family":"Pinto","sequence":"additional","affiliation":[{"name":"Department of Experimental Cardiology, Amsterdam Cardiovascular Sciences, Heart Failure & Arrhythmias, Amsterdam University Medical Centers, location AMC, University of Amsterdam , Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1878-9631","authenticated-orcid":false,"given":"Andrew","family":"Landstrom","sequence":"additional","affiliation":[{"name":"Department of Pediatrics (Division of Cardiology, Department of Cell Biology, Duke University School of Medicine , Durham, NC ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Serio","sequence":"additional","affiliation":[{"name":"Scientific Department, Centre for Inherited Cardiovascular Diseases, Fondazione IRCCS Policlinico San Matteo , Pavia ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathy","family":"Chikhaoui","sequence":"additional","affiliation":[{"name":"APHP, Centre de r\u00e9f\u00e9rence des maladies neuromusculaires Nord\/Est\/Ile de France, FILNEMUS, Myology Institute, Neuromyology Department, Piti\u00e9-Salp\u00eatri\u00e8re Hospital , Paris ,","place":["France"]},{"name":"Centre de Recherche en Myologie, Sorbonne Universit\u00e9, INSERM, Institut de Myologie , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5238-7791","authenticated-orcid":false,"given":"Nicolas","family":"Combes","sequence":"additional","affiliation":[{"name":"P\u00f4le de cardiologie p\u00e9diatrique et Cong\u00e9nitale, Clinique Pasteur , Toulouse ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Barnerias","sequence":"additional","affiliation":[{"name":"AP-HP, Centre de r\u00e9f\u00e9rence des maladies neuromusculaires Nord\/Est\/Ile de France, service de neurologie p\u00e9diatrique, H\u00f4pital Necker, GH Necker-Enfants malades , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henri-Marc","family":"B\u00e9cane","sequence":"additional","affiliation":[{"name":"APHP, Centre de r\u00e9f\u00e9rence des maladies neuromusculaires Nord\/Est\/Ile de France, FILNEMUS, Myology Institute, Neuromyology Department, Piti\u00e9-Salp\u00eatri\u00e8re Hospital , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Bieth","sequence":"additional","affiliation":[{"name":"Service de G\u00e9n\u00e9tique M\u00e9dicale, H\u00f4pital Purpan, CHU Toulouse , Toulouse ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6908-9678","authenticated-orcid":false,"given":"Franck","family":"Boccara","sequence":"additional","affiliation":[{"name":"AP-HP, Cardiology Department, H\u00f4pitaux de l'Est Parisien, H\u00f4pital Saint-Antoine, Sorbonne Universit\u00e9s, INSERM, UMR_S 938, Institut de Cardiom\u00e9tabolisme et Nutrition (ICAN), GRC 22 and C\u00b2MV , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8722-5805","authenticated-orcid":false,"given":"Damien","family":"Bonnet","sequence":"additional","affiliation":[{"name":"AP-HP, Unit\u00e9 M\u00e9dico-Chirurgicale de Cardiologie Cong\u00e9nitale et P\u00e9diatrique, Centre de r\u00e9f\u00e9rence des Malformations Cardiaques Cong\u00e9nitales Complexes-M3C, H\u00f4pital Necker Enfants Malades, Universit\u00e9 Paris-Cit\u00e9 , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Bouhour","sequence":"additional","affiliation":[{"name":"Hospices Civils de Lyon, Centre de r\u00e9f\u00e9rence des maladies neuromusculaires PACA-R\u00e9union-Rh\u00f4ne Alpes, Service d\u2019ENMG, H\u00f4pital Neurologique Pierre Wertheimer , Lyon-Bron ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Claire","family":"Brehin","sequence":"additional","affiliation":[{"name":"Department of Genetics and Reference Center for Developmental Abnormalities, Univ Rouen Normandie, Normandie Univ, Inserm U1245 and CHU Rouen , Rouen ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Cintas","sequence":"additional","affiliation":[{"name":"Centre de r\u00e9f\u00e9rence des maladies neuromusculaires AOC, D\u00e9partement de Neurologie, H\u00f4pital Purpan, CHU Toulouse , Toulouse ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5288-9687","authenticated-orcid":false,"given":"Fran\u00e7ois","family":"Roubille","sequence":"additional","affiliation":[{"name":"PhyMedExp, Universit\u00e9 de Montpellier, INSERM, CNRS, INI-CRT, Cardiology Department, CHU de Montpellier, Montpellier 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