{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T16:44:58Z","timestamp":1794329098288,"version":"4.9.0"},"reference-count":150,"publisher":"Oxford University Press (OUP)","issue":"23","license":[{"start":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, and inflammation has been suggested as a predisposing factor for AF. Systemic inflammatory disorders (including autoimmune disorder, diabetes mellitus, and obesity) or local inflammation of the heart or pericardium are linked to AF. Inflammation is known to trigger various signalling pathways and to directly influence proinflammatory cytokines, in turn promoting structural and electrical changes in the atria, increasing the susceptibility to AF. Inflammation induces oxidative stress and an imbalance in the autonomic nervous system, and enhances atrial or pulmonary vein arrhythmogenesis by modulating electrophysiological characteristics and fibrogenesis. This review explores the complex pathophysiological processes linking inflammation to AF and identifies potential novel therapeutic targets.<\/jats:p>","DOI":"10.1093\/eurheartj\/ehag131","type":"journal-article","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T12:42:20Z","timestamp":1774010540000},"page":"2894-2912","source":"Crossref","is-referenced-by-count":9,"title":["Inflammatory pathways in atrial fibrillation: mechanisms and novel therapeutic targets"],"prefix":"10.1093","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3010-3209","authenticated-orcid":false,"given":"Yen-Yu","family":"Lu","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Sijhih Cathay General Hospital , New Taipei City ,","place":["Taiwan"]},{"name":"School of Medicine, Fu-Jen Catholic University , New Taipei City ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7224-4491","authenticated-orcid":false,"given":"Yi-Jen","family":"Chen","sequence":"additional","affiliation":[{"name":"Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University , Taipei ,","place":["Taiwan"]},{"name":"Cardiovacular Research Center, Wan Fang Hospital, Taipei Medical University , Taipei ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7566-1626","authenticated-orcid":false,"given":"Gregory Y H","family":"Lip","sequence":"additional","affiliation":[{"name":"Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart & Chest Hospital , Liverpool ,","place":["UK"]},{"name":"Department of Clinical Medicine, Aalborg University , Aalborg ,","place":["Denmark"]},{"name":"Medical University of Bialystok , Bialystok ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9085-0823","authenticated-orcid":false,"given":"Shih-Ann","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Heart Rhythm Center, Taipei Veterans General Hospital , Taipei ,","place":["Taiwan"]},{"name":"Cardiovascular Center, Taichung Veterans General Hospital , 1650 Taiwan Boulevard Sect. 4, Taichung 40705 ,","place":["Taiwan"]},{"name":"Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University , Taichung ,","place":["Taiwan"]},{"name":"China Medical University Hospital , Taichung ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,3,25]]},"reference":[{"key":"2026061602203145500_ehag131-B1","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1161\/01.CIR.96.4.1180","article-title":"Histological substrate of atrial biopsies in patients with lone atrial fibrillation","volume":"96","author":"Frustaci","year":"1997","journal-title":"Circulation"},{"key":"2026061602203145500_ehag131-B2","doi-asserted-by":"publisher","first-page":"463","DOI":"10.12659\/MSM.890635","article-title":"Novel fibro-inflammation markers in assessing left atrial remodeling in non-valvular atrial fibrillation","volume":"20","author":"Sonmez","year":"2014","journal-title":"Med Sci Monit"},{"key":"2026061602203145500_ehag131-B3","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1378\/chest.100.2.303","article-title":"Cardiac biopsy in patients with \u2018primary\u2019 atrial fibrillation. 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