{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T01:23:31Z","timestamp":1794273811377,"version":"4.9.0"},"reference-count":77,"publisher":"Oxford University Press (OUP)","issue":"24","license":[{"start":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T00:00:00Z","timestamp":1773964800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Clinical Scientist Dekker"},{"name":"Dutch Heart Foundation","award":["03-005-2022-0040"],"award-info":[{"award-number":["03-005-2022-0040"]}],"id":[{"id":"https:\/\/ror.org\/05nxhgm70","id-type":"ROR","asserted-by":"crossref"}]},{"name":"ZonMW Veni"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Genetic testing has become an integral part of the diagnostic workup of patients with dilated cardiomyopathy (DCM). While the initial goal of genetic testing was to identify family members at risk, recent advances have now extended their relevance to clinical decision-making. Our knowledge of the genetic architecture of DCM has expanded significantly, promoting a shift from the monogenic dogma towards a broader polygenic spectrum. However, current genetic testing strategies still primarily rely on the model of monogenic inheritance with an incomplete penetrance. Large studies have shown a yield varying from 8% to 36% of genetic testing in patients with DCM, depending on aetiology or family history. Genetic testing is generally warranted for every patient with DCM where genetic results could have an impact on risk stratification, the prognosis or the treatment of the patient, or its family members with an opportunity for reassurance or early disease detection. There are various strategies for genetic testing including broad multigene panels, or more targeted panels limited to specific disease-associated genes. Identified variants are classified by genetic laboratories, where pathogenic or likely pathogenic variants often have actionable clinical implications. It is crucial to interpret these variants in the context of the individual patient considering the phenotype and other contributing factors. When the genetic results are consistent with the patients\u2019 broader phenotype, potential clinical implications may include decision for device therapy, recommendations for family screening, and reproductive options. A comprehensive approach to integrate genetic testing in the clinical care of patients with DCM is proposed.<\/jats:p>","DOI":"10.1093\/eurheartj\/ehag159","type":"journal-article","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T06:31:32Z","timestamp":1773988292000},"page":"3040-3051","source":"Crossref","is-referenced-by-count":6,"title":["Genetic counselling implementation in dilated cardiomyopathy"],"prefix":"10.1093","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5549-1298","authenticated-orcid":false,"given":"Job A J","family":"Verdonschot","sequence":"first","affiliation":[{"name":"Department of Clinical Genetics, Maastricht University Medical Center+ , P. Debyelaan 25, Maastricht 6229HX ,","place":["The Netherlands"]},{"name":"Department of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University , Maastricht ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin Y","family":"van Spaendonck-Zwarts","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics, Leiden University Medical Center , Leiden ,","place":["The Netherlands"]},{"name":"Department of Genetics, University Medical Center Groningen , Groningen ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debby M E I","family":"Hellebrekers","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics, Maastricht University Medical Center+ , P. Debyelaan 25, Maastricht 6229HX ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Folkert W","family":"Asselbergs","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centre, University of Amsterdam , Amsterdam ,","place":["The Netherlands"]},{"name":"Institute of Health Informatics, University College London , London ,","place":["UK"]},{"name":"The National Institute for Health Research University College London Hospitals Biomedical Research Centre, University College London , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elijah R","family":"Behr","sequence":"additional","affiliation":[{"name":"Cardiovascular and Genomics Research Institute, City St. George\u2019s, University of London , London ,","place":["UK"]},{"name":"Cardiovascular Clinical Academic Group, St. George\u2019s University Hospitals NHS Foundation Trust , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Charron","sequence":"additional","affiliation":[{"name":"Fili\u00e8re Nationale de Sant\u00e9 CARDIOGEN , Paris ,","place":["France"]},{"name":"Genetics and Cardiology Departments, APHP, Sorbonne Universit\u00e9, INSERM 1166, Institute of Cardiology and ICAN Institute for Cardiometabolism and Nutrition, Piti\u00e9-Salp\u00eatri\u00e8re Hospital , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2815-4469","authenticated-orcid":false,"given":"Dana","family":"Dawson","sequence":"additional","affiliation":[{"name":"Aberdeen Cardiovascular and Diabetes Centre, University of Aberdeen , Aberdeen ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Garcia-Pavia","sequence":"additional","affiliation":[{"name":"Heart Failure and Inherited Cardiac Diseases Unit, Department of Cardiology, Hospital Universitario Puerta de Hierro IDIPHISA , Madrid ,","place":["Spain"]},{"name":"CIBER Cardiovascular Instituto de Salud Carlos III , Madrid ,","place":["Spain"]},{"name":"Centro Nacional de Investigaciones Cardiovasculares (CNIC) , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4900-0453","authenticated-orcid":false,"given":"Kristina H","family":"Haugaa","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Karolinska University Hospital , Stockholm ,","place":["Sweden"]},{"name":"ProCardio Center, Department of Cardiology, Oslo University Hospital , Oslo ,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3438-2612","authenticated-orcid":false,"given":"Ruxandra","family":"Jurcut","sequence":"additional","affiliation":[{"name":"Expert Center for Genetic Cardiovascular Diseases, Emergency Institute for Cardiovascular Diseases \u2018Prof. Dr. C.C. 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