{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T07:07:52Z","timestamp":1794467272160,"version":"4.9.1"},"reference-count":33,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Union\u2019s Horizon 2020","award":["945119"],"award-info":[{"award-number":["945119"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Stereotactic arrhythmia radioablation (STAR) is increasingly used for refractory ventricular tachycardia (VT), yet prospective multicentre outcome data remain limited. Here, the planned interim analysis of the prospective Standardized Treatment and Outcome Platform for Stereotactic Therapy of Re-entrant tachycardia by a Multidisciplinary (STOPSTORM) registry is reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>STOPSTORM is a European prospective, international, multicentre registry of patients treated with STAR. The primary efficacy endpoint was the change in sustained VT episode burden comparing the 6 months before vs the 6 months after STAR. The primary safety endpoint was the occurrence of serious adverse events (SAEs) adjudicated as possibly or probably treatment-related. Overall survival was assessed using time-to-event methods.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Across 28 centres, 193 patients were included (mean age 68 \u00b1 9 years; 88% male; 53% non-ischaemic cardiomyopathy). Median follow-up was 19 months. Among 107 evaluable patients with \u22656-month follow-up, the median VT episode burden was reduced by 80% after STAR. Among patients surviving \u22656 months, 72% were free from implantable cardioverter-defibrillator (ICD) shock. In the full cohort, 12 SAEs were adjudicated as possibly or probably treatment-related, including pericardial effusion, coronary events, and early post-treatment ventricular arrhythmia. Overall survival probability was 77% at 12 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In the largest prospective multicentre cohort reported to date, STAR was associated with a substantial reduction in VT burden and ICD shocks, with a low frequency of possibly or probably treatment-related SAEs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurheartj\/ehag338","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T12:53:55Z","timestamp":1776430435000},"source":"Crossref","is-referenced-by-count":13,"title":["Stereotactic arrhythmia radioablation for refractory ventricular tachycardia: the STOPSTORM.eu study"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-4399-0672","authenticated-orcid":false,"given":"Luuk H G","family":"van der Pol","sequence":"first","affiliation":[{"name":"Department of Radiotherapy, University Medical Center Utrecht , Heidelberglaan 100, Utrecht 3584 CX ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5648-345X","authenticated-orcid":false,"given":"Bart\u0142omiej","family":"Tomasik","sequence":"additional","affiliation":[{"name":"Department of Oncology and Radiotherapy, Medical University of Gda\u0144sk , Gda\u0144sk ,","place":["Poland"]},{"name":"Department of Radiotherapy, Maria Sk\u0142odowska-Curie National Research Institute of Oncology , Gliwice ,","place":["Poland"]},{"name":"Centre of Experimental Cardiooncology, Medical University of Gda\u0144sk , Gda\u0144sk ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7334-6721","authenticated-orcid":false,"given":"Wiert F","family":"Hoeksema","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Amsterdam University Medical Center, Amsterdam Cardiovascular Sciences, Heart Failure and Arrhythmias , Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4612-5509","authenticated-orcid":false,"given":"Stefano","family":"Mandija","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy, University Medical Center Utrecht , Heidelberglaan 100, Utrecht 3584 CX ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4375-0827","authenticated-orcid":false,"given":"Marcin","family":"Miszczyk","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, University Medical Center Schleswig-Holstein , Kiel ,","place":["Germany"]},{"name":"Comprehensive Cancer Center, Medical University of Vienna Department of Urology, , Vienna ,","place":["Austria"]},{"name":"WSB University Collegium Medicum - Faculty of Medicine, , D\u0105browa G\u00f3rnicza ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6170-5122","authenticated-orcid":false,"given":"Melanie","family":"Grehn","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, University Medical Center Schleswig-Holstein , Kiel ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0559-4779","authenticated-orcid":false,"given":"Jasna","family":"But-Hadzic","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Institute of Oncology Ljubljana , Ljubljana ,","place":["Slovenia"]},{"name":"Faculty of Medicine, University of Ljubljana , Ljubljana ,","place":["Slovenia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8689-4011","authenticated-orcid":false,"given":"David","family":"Calvo","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Cl\u00ednico San Carlos, IdISSC and CIBERCV , Madrid ,","place":["Spain"]},{"name":"CIBERCV , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9742-515X","authenticated-orcid":false,"given":"Chiara","family":"Crico","sequence":"additional","affiliation":[{"name":"Legal Medicine and Bioethics, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia ,","place":["Italy"]},{"name":"Fondazione IRCCS Istituto Nazionale Tumori di Milano, Milan ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1579-1792","authenticated-orcid":false,"given":"Jakub","family":"Cvek","sequence":"additional","affiliation":[{"name":"Department of Oncology, University Hospital and Faculty of Medicine , Ostrava ,","place":["Czech 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Medical University of Silesia , Katowice ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3394-8511","authenticated-orcid":false,"given":"Stefan","family":"Jaschik","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Klinikum Chemnitz , Chemnitz ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8811-5416","authenticated-orcid":false,"given":"David","family":"Krug","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, University Medical Center Schleswig-Holstein , Kiel ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7668-3296","authenticated-orcid":false,"given":"Mario","family":"Levis","sequence":"additional","affiliation":[{"name":"Department of Oncology, Radiation Oncology Unit, University of Turin , Turin 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,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"del Pino Alcantara","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Hospital Cl\u00ednico San Carlos, IdISSC , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6044-5210","authenticated-orcid":false,"given":"Lukasz","family":"Dolla","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy, Maria Sk\u0142odowska-Curie National Research Institute of Oncology , Gliwice ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2290-3126","authenticated-orcid":false,"given":"Veronica","family":"Dusi","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medical Sciences, University of Turin , Turin 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,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4328-0319","authenticated-orcid":false,"given":"Niccol\u00f2","family":"Giaj-Levra","sequence":"additional","affiliation":[{"name":"Advanced Radiation Oncology Department, IRCCS Sacro Cuore Don Calabria Hospital, Cancer Care Center , Verona ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2432-7716","authenticated-orcid":false,"given":"Franziska","family":"Hausmann","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Charit\u00e9\u2014University Medicine Berlin , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0828-5874","authenticated-orcid":false,"given":"Colien","family":"Hazelaar","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology (Maastro), GROW Research 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,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8738-3352","authenticated-orcid":false,"given":"Mauro","family":"Iori","sequence":"additional","affiliation":[{"name":"Medical Physics Unit, Azienda USL\u2014IRCCS di Reggio Emilia , Reggio Emilia ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8151-3673","authenticated-orcid":false,"given":"Barbara A","family":"Jereczek-Fossa","sequence":"additional","affiliation":[{"name":"Department of Oncology and Hemato-oncology, University of Milan , Milan ,","place":["Italy"]},{"name":"Department of Radiation Oncology, IEO European Institute of Oncology IRCCS , Milan ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9334-5734","authenticated-orcid":false,"given":"Otakar","family":"Jiravsky","sequence":"additional","affiliation":[{"name":"Department 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,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9183-3012","authenticated-orcid":false,"given":"Annika","family":"Lattermann","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy and Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Dresden University of Technology , Dresden ,","place":["Germany"]},{"name":"University Hospital Carl Gustav Carus, Dresden University of Technology , Dresden ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7930-5197","authenticated-orcid":false,"given":"Tomasz","family":"Latusek","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy, Maria Sk\u0142odowska-Curie National Research Institute of Oncology , Gliwice 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