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Here, a two-step approach to identify children carrying FH-causing variants was investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this study from Southern Germany, paediatricians were invited to offer FH screening to all children aged 4.8\u201314.9 years at routine paediatric examinations. The FH screening programme began in September 2020 in Bavaria and has involved up to 480 paediatricians. It included biochemical and genetic testing using 0.2 mL of blood taken from a fingertip. In case of low-density lipoprotein cholesterol (LDL-C) serum concentration \u22653.36 mmol\/L (\u2265130 mg\/dL), FH-causing variants were determined in the same sample with a focused panel covering most frequent variants (n = 48) and sequencing of relevant genes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Out of 25 431 children screened so far, 1689 children had an LDL-C \u2265 3.36 mmol\/L (&amp;gt;130 mg\/dL), which defined this concentration as the 93rd percentile. Pathogenic variants were identified by the focused panel in 157 and by next-generation sequencing in 283 children, respectively. While 17% (283\/1670) of all genetically analysed children tested positive, the fraction of individuals with FH-causing variants increased across the spectrum of LDL-C serum concentrations from 4.7% (23\/492) at 3.36\u20133.49 mmol\/L (130\u2013135 mg\/dL) to 78.6% (81\/103) above 5.17 mmol\/L (200 mg\/dL). Overall, the prevalence of FH-causing variants was high (1:90). One reason was a founder variant (n = 63) within the LDLR gene, found 40 times more frequent than European average. The analysis of recruitment data revealed significant ascertainment bias, with lower recruitment rate practices exhibiting higher prevalence. After adjustment for the bias using a generalized linear mixed model, the predicted prevalence was 1 in 163 (0.61%), which is highly consistent with large-scale genomic benchmarks as gnomAD (1:165, n = 622 057) and the UK Biobank (1:176, n = 48 741).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The prevalence of FH determined in this study is significantly higher than previously published estimates (\u223c1:250), highlighting the importance of this condition for public health and supporting calls for a national paediatric screening programme, given the availability of effective treatment options. For children between 5 and 15 years, biochemical screening is an effective way to select patients for genetic testing, with sequencing of candidate genes being superior to variant screening. In summary, the VRONI study demonstrates the feasibility and efficacy of a combined biochemical and genetic screening for FH in children.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurheartj\/ehag403","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T11:32:15Z","timestamp":1778585535000},"page":"4641-4654","source":"Crossref","is-referenced-by-count":6,"title":["Genetic screening of children for familial hypercholesterolaemia: the VRONI study"],"prefix":"10.1093","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6583-256X","authenticated-orcid":false,"given":"Lea D","family":"Schlieben","sequence":"first","affiliation":[{"name":"Institute of Human Genetics, School of Medicine, Technical University of Munich , Trogerstra\u00dfe 32, Munich, 81675 ,","place":["Germany"]},{"name":"Institute of Neurogenomics, Computational Health Centre, Helmholtz Munich, Ingolst\u00e4dter Landstra\u00dfe , 1, Neuherberg, 85764 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