{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T22:28:55Z","timestamp":1793831335566,"version":"4.6.1"},"reference-count":39,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004410","name":"TUBITAK","doi-asserted-by":"publisher","award":["1059B192302470"],"award-info":[{"award-number":["1059B192302470"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Left ventricular assist device (LVAD) support has been shown to induce the reversal of neurohormonal changes and myocardial recovery. This study aimed to evaluate the prevalence, predictors, and clinical impact of left ventricular (LV) recovery after LVAD implantation using data from the European Registry for Patients with Mechanical Circulatory Support.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with at least one available left ventricular ejection fraction (LVEF) measurement at both baseline and post-LVAD implantation were enrolled. Left ventricular recovery was classified as \u2018no recovery\u2019 if LVEF increase was &amp;lt;5%, \u2018mild\u2019 if LVEF increased by 5%\u201315% with peak LVEF &amp;lt;50%, \u2018intermediate\u2019 if LVEF increased by &amp;gt;15% with peak LVEF &amp;lt;50%, and \u2018full\u2019 if LVEF increased by \u22655% with peak LVEF \u226550%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 1550 patients with a median age of 57 (48\u201364) years were included. LV recovery occurred mostly within the first year, with marginal probabilities of no, mild, intermediate, and full recovery at 4 years being 51% [95% confidence interval (CI) 48\u201354%), 41% (95% CI 38\u201343%), 8% (95% CI 7\u20139%), and 1% (95% CI 0\u20131%), respectively]. INTERMACS Classes 2, 3, and 4 [compared with Class 1; hazard ratio (HR) .72, .64, and .51, respectively] were associated with a lower hazard of attaining any LV recovery, whereas renin\u2013angiotensin system inhibitor use was associated with a higher hazard of attaining any LV recovery (HR 1.17; 95% CI 1.00\u20131.37). Each 10% higher LVEF value during follow-up was associated with an estimated 14% lower instantaneous hazard of all-cause mortality (HR .86; 95% credible interval .75\u2013.98). The cumulative incidence of the composite major adverse cardiovascular event endpoint, including cardiovascular death, late right heart failure, and arrhythmia beyond the first year, was lower across higher LV recovery categories defined according to the LVEF value at 1 year (Gray\u2019s test, P = .042).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This multicentre European study shows that LV recovery mostly occurs within the first year after LVAD implantation and is associated with better clinical outcomes. Renin\u2013angiotensin system inhibitor use was associated with both any and intermediate\/full LV recovery, while combination neurohormonal blockade strategies yielded directionally favourable but imprecise estimates, warranting further study during LVAD support.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurheartj\/ehag477","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T15:18:40Z","timestamp":1783610320000},"source":"Crossref","is-referenced-by-count":3,"title":["Left ventricular recovery and outcomes in patients with a durable left ventricular assist device: the EUROMACS registry"],"prefix":"10.1093","author":[{"given":"Yusuf Ziya","family":"Sener","sequence":"first","affiliation":[{"name":"Thoraxcenter, Department of Cardiology, Cardiovascular Institute, Erasmus MC University Medical Center , Rotterdam ,","place":["The 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