{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T01:53:09Z","timestamp":1794361989519,"version":"4.9.0"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"42","license":[{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["T2288101"],"award-info":[{"award-number":["T2288101"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007219","name":"Shanghai Natural Science Foundation","doi-asserted-by":"publisher","award":["23ZR1420900"],"award-info":[{"award-number":["23ZR1420900"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shanghai Top Priority Research Center Construction Project","award":["2022ZZ01010"],"award-info":[{"award-number":["2022ZZ01010"]}]},{"name":"ForQaly Medical (Shanghai) Co., Ltd."},{"name":"Chinese Pudong New Area Science and Technology Development Foundation","award":["PKX2023-S07"],"award-info":[{"award-number":["PKX2023-S07"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,11,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>The efficacy of prophylactic mechanical circulatory support with micro-axial flow pump or veno-arterial extracorporeal membrane oxygenation (VA-ECMO) in patients with severely reduced left ventricular ejection fraction (LVEF) undergoing high-risk percutaneous coronary intervention (PCI) remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with complex three-vessel disease, unprotected left main coronary disease or last patent conduit and LVEF \u2264 35% were assigned to receive either a micro-axial flow pump (SynFlow 3.0) or VA-ECMO support during a non-emergent high-risk PCI procedure in this prospective, multicentre, randomized, open-label, non-inferiority trial. The primary endpoint was the incidence of 30-day major adverse events, defined as any of: all-cause death, myocardial infarction, stroke\/transient ischaemic attack, repeat revascularization, major bleeding, acute kidney injury, cardiopulmonary resuscitation\/cardioversion, cardiac surgery\/limb ischaemia, or serious device-related complications. Safety endpoints included adverse events and serious adverse events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The primary endpoint, 30-day major adverse events, occurred in 8 of 109 patients (7.34%) in the SynFlow 3.0 group and 13 of 113 patients (11.5%) in the VA-ECMO group (absolute difference adjusted for centre effect, \u22124.6%; 95% confidence interval, \u221212.6% to 3.5%; P for non-inferiority &amp;lt; .001). Patients with SynFlow 3.0 had shorter post-procedural hospital stay (4.1 days vs 5.2 days on average, P = .047) and fewer device-related adverse events (3.7% vs 11.5%; P = .041). Anaemia occurred more often with VA-ECMO than with SynFlow 3.0 (20.4% vs 9.2%; P = .023).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The prophylactic use of a micro-axial flow pump during high-risk PCI procedures was non-inferior to VA-ECMO in the incidence of 30-day major adverse events. The use of a micro-axial flow pump was associated with shorter post-procedural hospital stay and fewer device-related adverse events.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurheartj\/ehag520","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T13:43:02Z","timestamp":1785159782000},"page":"6314-6328","source":"Crossref","is-referenced-by-count":2,"title":["Micro-axial flow pump vs veno-arterial extracorporeal membrane oxygenation for high-risk percutaneous coronary interventions: a randomized trial"],"prefix":"10.1093","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-1378-8188","authenticated-orcid":false,"given":"Gang","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Cardiology, Zhongshan Hospital, Fudan University , Shanghai 200032 ,","place":["China"]},{"name":"National Clinical Research Center for Interventional Medicine , Shanghai 200032 ,","place":["China"]},{"name":"National Clinical 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