{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T16:45:09Z","timestamp":1792860309948,"version":"4.5.0"},"reference-count":42,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T00:00:00Z","timestamp":1786147200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100008695","name":"Japan Foundation for Applied Enzymology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008695","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008732","name":"Uehara Memorial Foundation Postdoctoral Fellowship","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008732","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"JSPS KAKENHI","doi-asserted-by":"publisher","award":["JP24K22274"],"award-info":[{"award-number":["JP24K22274"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"JSPS KAKENHI","doi-asserted-by":"publisher","award":["JP24K02449"],"award-info":[{"award-number":["JP24K02449"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Advances in therapeutics and interventions have enabled the comprehensive management of patients with heart failure (HF); however, real-world clinical practice remains poorly characterized. This study aimed to evaluate temporal changes in HF management and their impact on patient outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Two large-scale Japanese HF registries were compared: the JROADHF (2013, n = 13 238) and JROADHF-NEXT (2019\u201321, n = 4016). Propensity score matching (1:1) was performed to compare patient outcomes between cohorts and identify factors associated with outcome improvements.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Propensity score matching yielded 2972 patients in each cohort. After matching, guideline-recommended therapy increased for renin\u2013angiotensin system inhibitors (70.9% vs 73.1%), beta-blockers (74.9% vs 80.8%), mineralocorticoid receptor antagonists (54.2% vs 61.1%), cardiac rehabilitation (43.5% vs 88.8%), and nutritional guidance (2.9% vs 56.1%) in the 2013 and 2019\u201321 cohorts, respectively. The 2019\u201321 cohort demonstrated 26.7% and 52.1% reductions in 1-year mortality and HF readmission rate (P &amp;lt; .001 for both), respectively, compared with the 2013 cohort. Improved mortality was associated with pharmacotherapy [renin\u2013angiotensin system inhibitors: hazard ratio (HR) .71, 95% confidence interval (CI) .64\u2013.80, P &amp;lt; .001; beta-blockers: HR .85, 95% CI .75\u2013.96, P = .012] and patient education (nutritional guidance: HR .76, 95% CI .64\u2013.89, P = .001). The cohort effect was the strongest predictor of HF readmission (subdistribution HR .49, 95% CI: .43\u2013.57, P &amp;lt; .001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Long-term outcomes of patients with HF improved between 2013 and 2019\u201321. Guideline-recommended therapy was associated with survival benefit, whereas marked reduction in HF readmission rates coincided with broader changes in post-discharge care and healthcare system.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurheartj\/ehag577","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T11:55:21Z","timestamp":1783684521000},"source":"Crossref","is-referenced-by-count":1,"title":["Temporal comparison of clinical practice and outcomes in heart failure: the JROADHF and JROADHF-NEXT studies"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7300-8180","authenticated-orcid":false,"given":"Takeshi","family":"Tohyama","sequence":"first","affiliation":[{"name":"Institute for Medical Engineering and Science, Massachusetts Institute of Technology , 77 Massachusetts Avenue, Cambridge, MA 02139 ,","place":["USA"]},{"name":"Department of Cardiovascular Medicine, Faculty of Medical Sciences, 3-1-1 Maidashi, Higashi-ku, Kyushu University , Fukuoka 812-8582 ,","place":["Japan"]},{"name":"Division of Cardiovascular Medicine, Research Institute of Angiocardiology, Faculty of Medical Sciences, 3-1-1 Maidashi, Higashi-ku, Kyushu University , Fukuoka 812-8582 ,","place":["Japan"]},{"name":"School of Health Sciences at Fukuoka, International University of Health and Welfare , 137-1 Enokizu, Okawa Fukuoka 831-8501 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1893-8171","authenticated-orcid":false,"given":"Masataka","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Faculty of Medical Sciences, 3-1-1 Maidashi, Higashi-ku, Kyushu University , Fukuoka 812-8582 ,","place":["Japan"]},{"name":"Division of Cardiovascular Medicine, Research Institute of Angiocardiology, Faculty of Medical Sciences, 3-1-1 Maidashi, Higashi-ku, Kyushu University , Fukuoka 812-8582 ,","place":["Japan"]},{"name":"Department of Cardiovascular Medicine, Kyushu University Beppu Hospital , Oita ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Faculty of Medical Sciences, 3-1-1 Maidashi, Higashi-ku, Kyushu University , Fukuoka 812-8582 ,","place":["Japan"]},{"name":"Division of Cardiovascular Medicine, Research Institute of Angiocardiology, Faculty of Medical Sciences, 3-1-1 Maidashi, Higashi-ku, Kyushu University , Fukuoka 812-8582 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3899-4405","authenticated-orcid":false,"given":"Nobuyuki","family":"Enzan","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Faculty of Medical Sciences, 3-1-1 Maidashi, Higashi-ku, Kyushu University , Fukuoka 812-8582 ,","place":["Japan"]},{"name":"Division of Cardiovascular Medicine, Research Institute of Angiocardiology, Faculty of Medical Sciences, 3-1-1 Maidashi, Higashi-ku, Kyushu University , Fukuoka 812-8582 ,","place":["Japan"]},{"name":"School of Health Sciences at Fukuoka, International University of Health and Welfare , 137-1 Enokizu, Okawa Fukuoka 831-8501 ,","place":["Japan"]},{"name":"Cardiovascular Disease Initiative of MIT and Harvard , Broad Institute , Cambridge, MA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidetaka","family":"Kaku","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, JCHO Kyushu Hospital , Fukuoka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eri","family":"Noda","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Faculty of Medical Sciences, 3-1-1 Maidashi, Higashi-ku, Kyushu University , Fukuoka 812-8582 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