{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:06:54Z","timestamp":1791389214777,"version":"4.3.3"},"reference-count":30,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"AP M\u00f8ller og hustru Chastine McKinney M\u00f8llers Fond"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>To assess the prevalence of subclinical coronary atherosclerosis and its association with myocardial infarction, death or myocardial infarction, and clinically driven coronary revascularization in asymptomatic women and men in a Danish general population cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Asymptomatic women (n = 5710, 57%) and men (n = 4293, 43%) &amp;gt;40 years underwent coronary computed tomography angiography. The primary endpoint was myocardial infarction, while secondary endpoints were death or myocardial infarction combined and clinically driven coronary revascularization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>From 40 through to &amp;gt;80 years of age, women had less subclinical coronary atherosclerosis than men (P for gender interaction &amp;lt;.0001), both in persons with and without cardiovascular risk factors. Median follow-up was 6.0 years (interquartile range: 3.9\u20139.5). In individuals with vs without obstructive subclinical coronary atherosclerosis, the adjusted hazard ratio for having a myocardial infarction was 4.1 (95% confidence interval: 1.5\u201311) in women and 12 (4.6\u201334) in men (P for gender interaction = .24). Corresponding hazard ratios for death or myocardial infarction combined were 1.9 (1.3\u20132.9) and 2.7 (1.9\u20133.9), respectively (P for gender interaction = .30). Finally, corresponding hazard ratios for clinically driven coronary revascularization were 23 (5.2\u2013106) and 34 (11\u2013106), respectively (P for gender interaction = .35).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>For the same degree of subclinical coronary atherosclerosis, women may have a lower risk of myocardial infarction than men. These novel findings show that in asymptomatic women and men, the presence of obstructive subclinical coronary atherosclerosis conferred a fourfold and 12-fold risk of myocardial infarction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurheartj\/ehag612","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T12:01:48Z","timestamp":1784721708000},"source":"Crossref","is-referenced-by-count":1,"title":["Gender-related risk of myocardial infarction and subclinical coronary atherosclerosis: a Danish population cohort study"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0236-0811","authenticated-orcid":false,"given":"Andreas Fuchs","family":"Larsen","sequence":"first","affiliation":[{"name":"Department of Cardiology, the Heart Center, Copenhagen University Hospital\u2014Rigshospitalet , Copenhagen ,","place":["Denmark"]},{"name":"Department of Cardiology, Copenhagen University Hospital\u2014Amager and Hvidovre , 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,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1954-7220","authenticated-orcid":false,"given":"B\u00f8rge Gr\u00f8nne","family":"Nordestgaard","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Copenhagen University Hospital\u2014Herlev and Gentofte , Herlev ,","place":["Denmark"]},{"name":"Copenhagen General Population Study, Copenhagen University Hospital\u2014Herlev and Gentofte , Herlev ,","place":["Denmark"]},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6635-1466","authenticated-orcid":false,"given":"Lars","family":"K\u00f8ber","sequence":"additional","affiliation":[{"name":"Department of Cardiology, the Heart Center, Copenhagen University Hospital\u2014Rigshospitalet , Copenhagen 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