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The aim of this study was to recalibrate the Systematic COronary Risk Evaluation 2 (SCORE2) risk models for estimating 10-year CVD risk in individuals without prior CVD or diabetes mellitus in LAC, resulting in the SCORE2 Latin America and the Caribbean (SCORE2-LAC) models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Sex-specific, competing risk-adjusted SCORE2 models were recalibrated to contemporary CVD incidence across four risk regions, defined by country-level age- and sex-standardized CVD mortality rates, using region-specific risk factor distributions. Cardiovascular disease incidence was estimated from CVD mortality data and ratios of the total first-to-fatal CVD events, derived from 40 237 152 individuals (1 261 329 CVD events). External validation included 132 512 individuals without prior CVD or diabetes from 11 cohorts across seven countries (3938 CVD events). Discrimination was assessed using Harrell\u2019s C-index.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the external validation datasets, the pooled C-index of SCORE2-LAC was .740 [95% confidence interval (CI) .716\u2013.763], with cohort-specific C-indices ranging from .674 (95% CI .588\u2013.761) to .789 (95% CI .747\u2013.831). Estimated CVD risk varied several-fold across the four LAC risk regions. For a 50-year-old non-smoker with a systolic blood pressure of 140\u2005mmHg, total cholesterol of 213\u2005mg\/dL (5.5\u2005mmol\/L), and HDL cholesterol of 50\u2005mg\/dL (1.3\u2005mmol\/L), the predicted risk ranged from 3% in low-risk countries to 10% in very-high-risk countries for women, and from 4% to 10% for men.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The SCORE2-LAC models provide region-specific contemporary estimates of 10-year CVD risk in apparently healthy individuals, enabling identification of individuals at high CVD risk across LAC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurheartj\/ehag698","type":"journal-article","created":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T13:47:07Z","timestamp":1788011227000},"source":"Crossref","is-referenced-by-count":0,"title":["Development and external validation of the SCORE2 models in Latin America and the Caribbean (SCORE2-LAC) to estimate 10-year cardiovascular disease risk"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6330-9353","authenticated-orcid":false,"given":"Stella","family":"Bijkerk","sequence":"first","affiliation":[{"name":"Department of Vascular Medicine & Endocrinology, University Medical Center Utrecht , Heidelberglaan 100, Utrecht 3584 CX ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4864-1088","authenticated-orcid":false,"given":"Carlos I","family":"Ponte-Negretti","sequence":"additional","affiliation":[{"name":"Cardiometabolic Medicine Unit, La Floresta Medical Institute , Caracas ,","place":["Venezuela"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3506-3701","authenticated-orcid":false,"given":"Ko Ko","family":"Maung","sequence":"additional","affiliation":[{"name":"Department of Medicine, 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