{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T13:01:57Z","timestamp":1791118917862,"version":"4.1.0"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"15","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,8]]},"DOI":"10.1093\/eurheartj\/ehr119","type":"journal-article","created":{"date-parts":[[2011,4,28]],"date-time":"2011-04-28T00:26:49Z","timestamp":1303950409000},"page":"1954-1963","source":"Crossref","is-referenced-by-count":82,"title":["Regulation of adverse remodelling by osteopontin in a genetic heart failure model"],"prefix":"10.1093","volume":"33","author":[{"given":"Stelios","family":"Psarras","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manolis","family":"Mavroidis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Despina","family":"Sanoudou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantinos H.","family":"Davos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgina","family":"Xanthou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aimilia E.","family":"Varela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vily","family":"Panoutsakopoulou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yassemi","family":"Capetanaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,4,26]]},"reference":[{"key":"key\n\t\t\t\t20170515130759_EHR119C1","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1016\/j.yexcr.2007.03.033","article-title":"Muscle intermediate filaments and their links to membranes and membranous organelles","volume":"313","year":"2007","journal-title":"Exp Cell Res"},{"key":"key\n\t\t\t\t20170515130759_EHR119C2","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1097\/HCO.0b013e32832a1d2e","article-title":"Restrictive cardiomyopathy","volume":"24","year":"2009","journal-title":"Curr Opin Cardiol"},{"key":"key\n\t\t\t\t20170515130759_EHR119C3","first-page":"1","article-title":"Desmin-related myopathy: a review and meta-analysis","volume":"1","year":"2010","journal-title":"Clin Genet"},{"key":"key\n\t\t\t\t20170515130759_EHR119C4","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1083\/jcb.200710049","article-title":"Desmin mediates TNF-alpha-induced aggregate formation and intercalated disk reorganization in heart failure","volume":"181","year":"2008","journal-title":"J Cell Biol"},{"key":"key\n\t\t\t\t20170515130759_EHR119C5","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1161\/hh1301.092688","article-title":"Expression of R120G-alphaB-crystallin causes aberrant desmin and alphaB-crystallin aggregation and cardiomyopathy in mice","volume":"89","year":"2001","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20170515130759_EHR119C6","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1083\/jcb.150.6.1283","article-title":"Desmin cytoskeleton linked to muscle mitochondrial distribution and respiratory function","volume":"150","year":"2000","journal-title":"J Cell Biol"},{"key":"key\n\t\t\t\t20170515130759_EHR119C7","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1023\/A:1009813621103","article-title":"The cytoskeleton and related proteins in the human failing heart","volume":"5","year":"2000","journal-title":"Heart Fail Rev"},{"key":"key\n\t\t\t\t20170515130759_EHR119C8","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1083\/jcb.134.5.1255","article-title":"Disruption of muscle architecture and myocardial degeneration in mice lacking desmin","volume":"134","year":"1996","journal-title":"J Cell Biol"},{"key":"key\n\t\t\t\t20170515130759_EHR119C9","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1006\/dbio.1996.0122","article-title":"Cardiovascular lesions and skeletal myopathy in mice lacking desmin","volume":"175","year":"1996","journal-title":"Dev Biol"},{"key":"key\n\t\t\t\t20170515130759_EHR119C10","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1006\/jmcc.1999.1037","article-title":"The absence of desmin leads to cardiomyocyte hypertrophy and cardiac dilation with compromised systolic function","volume":"31","year":"1999","journal-title":"J Mol Cell Cardiol"},{"key":"key\n\t\t\t\t20170515130759_EHR119C11","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/S0002-9440(10)64916-4","article-title":"Extensive induction of important mediators of fibrosis and dystrophic calcification in desmin-deficient cardiomyopathy","volume":"160","year":"2002","journal-title":"Am J Pathol"},{"key":"key\n\t\t\t\t20170515130759_EHR119C12","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1073\/pnas.0303202101","article-title":"Bcl-2 overexpression corrects mitochondrial defects and ameliorates inherited desmin null cardiomyopathy","volume":"101","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20170515130759_EHR119C13","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S1388-9842(01)00237-9","article-title":"Increased myocardial expression of osteopontin in patients with advanced heart failure","volume":"4","year":"2002","journal-title":"Eur J Heart Fail"},{"key":"key\n\t\t\t\t20170515130759_EHR119C14","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1038\/nm1580","article-title":"Osteopontin has a crucial role in allergic airway disease through regulation of dendritic cell subsets","volume":"13","year":"2007","journal-title":"Nat Med"},{"key":"key\n\t\t\t\t20170515130759_EHR119C15","doi-asserted-by":"crossref","first-page":"H673","DOI":"10.1152\/ajpheart.00569.2006","article-title":"Lack of osteopontin improves cardiac function in streptozotocin-induced diabetic mice","volume":"292","year":"2007","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"key\n\t\t\t\t20170515130759_EHR119C16","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1161\/hh1001.090842","article-title":"Exaggerated left ventricular dilation and reduced collagen deposition after myocardial infarction in mice lacking osteopontin","volume":"88","year":"2001","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20170515130759_EHR119C17","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1161\/01.HYP.0000128621.68160.dd","article-title":"Role of osteopontin in cardiac fibrosis and remodeling in angiotensin II-induced cardiac hypertrophy","volume":"43","year":"2004","journal-title":"Hypertension"},{"key":"key\n\t\t\t\t20170515130759_EHR119C18","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1172\/JCI2131","article-title":"Altered wound healing in mice lacking a functional osteopontin gene (spp1)","volume":"101","year":"1998","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20170515130759_EHR119C19","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/0092-8674(92)90030-G","article-title":"RAG-1-deficient mice have no mature B and T lymphocytes","volume":"68","year":"1992","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170515130759_EHR119C20","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s10741-010-9158-6","article-title":"Role of osteopontin in heart failure associated with aging","volume":"15","year":"2010","journal-title":"Heart Fail Rev"},{"key":"key\n\t\t\t\t20170515130759_EHR119C21","doi-asserted-by":"crossref","first-page":"3121","DOI":"10.1161\/01.CIR.0000147181.65298.4D","article-title":"Galectin-3 marks activated macrophages in failure-prone hypertrophied hearts and contributes to cardiac dysfunction","volume":"110","year":"2004","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20170515130759_EHR119C22","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.bbrc.2007.03.035","article-title":"Transgenic expression of osteoactivin in the liver attenuates hepatic fibrosis in rats","volume":"356","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"key":"key\n\t\t\t\t20170515130759_EHR119C23","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1165\/ajrcmb.38.2.247a","article-title":"Does MMP-12 play a role in human lung fibrosis?","volume":"38","year":"2008","journal-title":"Am J Respir Cell Mol Biol"},{"key":"key\n\t\t\t\t20170515130759_EHR119C24","doi-asserted-by":"crossref","first-page":"5060","DOI":"10.1073\/pnas.0511167103","article-title":"Galectin-3 regulates myofibroblast activation and hepatic fibrosis","volume":"103","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20170515130759_EHR119C25","doi-asserted-by":"crossref","first-page":"14769","DOI":"10.1074\/jbc.M901515200","article-title":"Polymeric osteopontin employs integrin alpha9beta1 as a receptor and attracts neutrophils by presenting a de novo binding site","volume":"284","year":"2009","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170515130759_EHR119C26","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1161\/CIRCHEARTFAILURE.109.898114","article-title":"Osteopontin expression in cardiomyocytes induces dilated cardiomyopathy","volume":"3","year":"2010","journal-title":"Circ Heart Fail"},{"key":"key\n\t\t\t\t20170515130759_EHR119C27","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1038\/nm1633","article-title":"Adaptive immune cells temper initial innate responses","volume":"13","year":"2007","journal-title":"Nat Med"},{"key":"key\n\t\t\t\t20170515130759_EHR119C28","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.phrs.2008.06.007","article-title":"The immune system and cardiac repair","volume":"58","year":"2008","journal-title":"Pharmacol Res"},{"key":"key\n\t\t\t\t20170515130759_EHR119C29","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/nri2215","article-title":"How dying cells alert the immune system to danger","volume":"8","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"key\n\t\t\t\t20170515130759_EHR119C30","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1093\/eurjhf\/hfp097","article-title":"Galectin-3: a novel mediator of heart failure development and progression","volume":"11","year":"2009","journal-title":"Eur J Heart Fail"},{"key":"key\n\t\t\t\t20170515130759_EHR119C31","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.ejheart.2004.10.019","article-title":"Myocardial osteopontin expression is associated with collagen fibrillogenesis in human dilated cardiomyopathy","volume":"7","year":"2005","journal-title":"Eur J Heart Fail"},{"key":"key\n\t\t\t\t20170515130759_EHR119C32","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1161\/CIRCRESAHA.109.193805","article-title":"Osteopontin: a fibrosis-related marker molecule in cardiac remodeling of enterovirus myocarditis in the susceptible host","volume":"104","year":"2009","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20170515130759_EHR119C33","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s11010-008-9939-6","article-title":"Inhibition of matrix metalloproteinases improves left ventricular function in mice lacking osteopontin after myocardial infarction","volume":"322","year":"2009","journal-title":"Mol Cell Biochem"},{"key":"key\n\t\t\t\t20170515130759_EHR119C34","doi-asserted-by":"crossref","first-page":"H1730","DOI":"10.1152\/ajpheart.00098.2004","article-title":"Increased cell death in osteopontin-deficient cardiac fibroblasts occurs by a caspase-3-independent pathway","volume":"287","year":"2004","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"key\n\t\t\t\t20170515130759_EHR119C35","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1161\/CIRCRESAHA.107.160408","article-title":"Osteopontin expression is required for myofibroblast differentiation","volume":"102","year":"2008","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20170515130759_EHR119C36","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1172\/JCI119031","article-title":"Osteopontin is produced by rat cardiac fibroblasts and mediates A(II)-induced DNA synthesis and collagen gel contraction","volume":"98","year":"1996","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20170515130759_EHR119C37","doi-asserted-by":"crossref","first-page":"H404","DOI":"10.1152\/ajpheart.00747.2008","article-title":"N-acetyl-seryl-aspartyl-lysyl-proline prevents cardiac remodeling and dysfunction induced by galectin-3, a mammalian adhesion\/growth-regulatory lectin","volume":"296","year":"2009","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"key\n\t\t\t\t20170515130759_EHR119C38","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/nri2460","article-title":"Regulation of T-helper-cell lineage development by osteopontin: the inside story","volume":"9","year":"2009","journal-title":"Nat Rev Immunol"},{"key":"key\n\t\t\t\t20170515130759_EHR119C39","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1126\/science.287.5454.860","article-title":"Eta-1 (osteopontin): an early component of type-1 (cell-mediated) immunity","volume":"287","year":"2000","journal-title":"Science"},{"key":"key\n\t\t\t\t20170515130759_EHR119C40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cellimm.2004.01.001","article-title":"Impaired anti-tumor cytotoxicity of macrophages from osteopontin-deficient mice","volume":"227","year":"2004","journal-title":"Cell Immunol"},{"key":"key\n\t\t\t\t20170515130759_EHR119C41","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/j.yexcr.2006.12.026","article-title":"A constitutive endogenous osteopontin production is important for macrophage function and differentiation","volume":"313","year":"2007","journal-title":"Exp Cell Res"},{"key":"key\n\t\t\t\t20170515130759_EHR119C42","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1002\/art.27400","article-title":"Osteopontin deficiency impairs wear debris-induced osteolysis via regulation of cytokine secretion from murine macrophages","volume":"62","year":"2010","journal-title":"Arthritis Rheum"},{"key":"key\n\t\t\t\t20170515130759_EHR119C43","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.2353\/ajpath.2010.091081","article-title":"Cleavage of osteopontin by matrix metalloproteinase-12 modulates experimental autoimmune encephalomyelitis disease in C57BL\/6 mice","volume":"177","year":"2010","journal-title":"Am J Pathol"},{"key":"key\n\t\t\t\t20170515130759_EHR119C44","doi-asserted-by":"crossref","first-page":"6557","DOI":"10.4049\/jimmunol.178.10.6557","article-title":"Gpnmb is induced in macrophages by IFN-gamma and lipopolysaccharide and acts as a feedback regulator of proinflammatory responses","volume":"178","year":"2007","journal-title":"J Immunol"}],"container-title":["European Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/eurheartj\/article-pdf\/33\/15\/1954\/17049893\/ehr119.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,10]],"date-time":"2019-06-10T10:36:09Z","timestamp":1560162969000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eurheartj\/article-lookup\/doi\/10.1093\/eurheartj\/ehr119"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4,26]]},"references-count":44,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2011,4,26]]},"published-print":{"date-parts":[[2012,8]]}},"URL":"https:\/\/doi.org\/10.1093\/eurheartj\/ehr119","relation":{},"ISSN":["0195-668X","1522-9645"],"issn-type":[{"value":"0195-668X","type":"print"},{"value":"1522-9645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,4,26]]}}}