{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T02:20:56Z","timestamp":1790734856502,"version":"4.1.0"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,1,21]]},"DOI":"10.1093\/eurheartj\/ehs199","type":"journal-article","created":{"date-parts":[[2012,7,10]],"date-time":"2012-07-10T22:12:31Z","timestamp":1341958351000},"page":"258-267","source":"Crossref","is-referenced-by-count":207,"title":["Clinical implications of provocation tests for coronary artery spasm: safety, arrhythmic complications, and prognostic impact: Multicentre Registry Study of the Japanese Coronary Spasm Association"],"prefix":"10.1093","volume":"34","author":[{"given":"Yusuke","family":"Takagi","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Yasuda","sequence":"additional","affiliation":[{"name":"National Cerebral and Cardiovascular Center, Suita, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryusuke","family":"Tsunoda","sequence":"additional","affiliation":[{"name":"Japanese Red Cross Kumamoto Hospital, Kumamoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Ogata","sequence":"additional","affiliation":[{"name":"Japanese Red Cross Kumamoto Hospital, Kumamoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Seki","sequence":"additional","affiliation":[{"name":"Sakakibara Heart Institute, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Sumiyoshi","sequence":"additional","affiliation":[{"name":"Sakakibara Heart Institute, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motoyuki","family":"Matsui","sequence":"additional","affiliation":[{"name":"Yamagata Prefectural Central Hospital, Yamagata, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshikazu","family":"Goto","sequence":"additional","affiliation":[{"name":"Yamagata Prefectural Central Hospital, Yamagata, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiko","family":"Tanabe","sequence":"additional","affiliation":[{"name":"Niigata Prefectural Shibata Hospital, Shibata, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shozo","family":"Sueda","sequence":"additional","affiliation":[{"name":"Ehime Prefectural Niihama Hospital, Niihama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiaki","family":"Sato","sequence":"additional","affiliation":[{"name":"Keio University School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Keio University School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norifumi","family":"Kubo","sequence":"additional","affiliation":[{"name":"Jichi Medical University Saitama Medical Center, Saitama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin-ichi","family":"Momomura","sequence":"additional","affiliation":[{"name":"Jichi Medical University Saitama Medical Center, Saitama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisao","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Shimokawa","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the Japanese Coronary Spasm Association","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,7,10]]},"reference":[{"key":"key\n\t\t\t\t20180328174257_EHS199C1","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1253\/circj.CJ-09-0033","article-title":"Role of coronary vasoconstriction in ischemic heart disease and search for novel therapeutic targets","volume":"73","author":"Maseri","year":"2009","journal-title":"Circ J"},{"key":"key\n\t\t\t\t20180328174257_EHS199C2","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1161\/CIRCULATIONAHA.108.843474","article-title":"Coronary artery spasm: a 2009 update","volume":"119","author":"Stern","year":"2009","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20180328174257_EHS199C3","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/j.jacc.2011.05.044","article-title":"New light on a forgotten disease vasospastic angina","volume":"58","author":"Crea","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"key\n\t\t\t\t20180328174257_EHS199C4","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1253\/circj.CJ-09-0061","article-title":"Importance of dual induction tests for coronary vasospasm and ventricular fibrillation in patients surviving out-of-hospital cardiac arrest","volume":"73","author":"Takagi","year":"2009","journal-title":"Circ J"},{"key":"key\n\t\t\t\t20180328174257_EHS199C5","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/0002-9343(59)90003-8","article-title":"Angina pectoris. I. A variant form of angina pectoris; preliminary report","volume":"27","author":"Prinzmetal","year":"1959","journal-title":"Am J Med"},{"key":"key\n\t\t\t\t20180328174257_EHS199C6","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1161\/01.CIR.68.2.258","article-title":"Factors influencing the long-term prognosis of treated patients with variant angina","volume":"68","author":"Waters","year":"1983","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20180328174257_EHS199C7","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1161\/01.CIR.76.5.990","article-title":"Long-term prognosis of patients with variant angina","volume":"76","author":"Walling","year":"1987","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20180328174257_EHS199C8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1161\/01.CIR.78.1.1","article-title":"Long-term prognosis for patients with variant angina and influential factors","volume":"78","author":"Yasue","year":"1988","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20180328174257_EHS199C9","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/0167-5273(88)90052-6","article-title":"Clinical characteristics and long-term prognosis of patients with variant angina. A comparative study between western and Japanese populations","volume":"18","author":"Shimokawa","year":"1988","journal-title":"Int J Cardiol"},{"key":"key\n\t\t\t\t20180328174257_EHS199C10","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1161\/CIRCEP.110.959809","article-title":"Clinical characteristics and long-term prognosis of vasospastic angina patients who survived out-of-hospital cardiac arrest: multicenter registry study of the Japanese Coronary Spasm Association","volume":"4","author":"Takagi","year":"2011","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"key\n\t\t\t\t20180328174257_EHS199C11","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1093\/eurheartj\/ehp151","article-title":"A randomized placebo-controlled study on the effect of nifedipine on coronary endothelial function and plaque formation in patients with coronary artery disease: the ENCORE II study","volume":"30","author":"Luscher","year":"2009","journal-title":"Eur Heart J"},{"key":"key\n\t\t\t\t20180328174257_EHS199C12","doi-asserted-by":"crossref","first-page":"2758","DOI":"10.1093\/eurheartj\/ehr221","article-title":"Myocardial ischaemia in patients with coronary endothelial dysfunction: insights from body surface ECG mapping and implications for invasive evaluation of chronic chest pain","volume":"32","author":"Summers","year":"2011","journal-title":"Eur Heart J"},{"key":"key\n\t\t\t\t20180328174257_EHS199C13","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1016\/j.jacc.2007.06.031","article-title":"Sirolimus-eluting stent implantation aggravates endothelial vasomotor dysfunction in the infarct-related coronary artery in patients with acute myocardial infarction","volume":"50","author":"Obata","year":"2007","journal-title":"J Am Coll Cardiol"},{"key":"key\n\t\t\t\t20180328174257_EHS199C14","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1161\/01.CIR.65.7.1299","article-title":"Frequency of provoked coronary arterial spasm in 1089 consecutive patients undergoing coronary arteriography","volume":"65","author":"Bertrand","year":"1982","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20180328174257_EHS199C15","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1016\/S0002-9149(99)00057-0","article-title":"Frequency of provoked coronary vasospasm in patients undergoing coronary arteriography with spasm provocation test of acetylcholine","volume":"83","author":"Sueda","year":"1999","journal-title":"Am J Cardiol"},{"key":"key\n\t\t\t\t20180328174257_EHS199C16","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0002-9149(99)00754-7","article-title":"Major complications during spasm provocation tests with an intracoronary injection of acetylcholine","volume":"85","author":"Sueda","year":"2000","journal-title":"Am J Cardiol"},{"key":"key\n\t\t\t\t20180328174257_EHS199C17","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/0002-9149(80)90080-6","article-title":"Refractory ergonovine-induced coronary vasospasm: importance of intracoronary nitroglycerin","volume":"46","author":"Buxton","year":"1980","journal-title":"Am J Cardiol"},{"key":"key\n\t\t\t\t20180328174257_EHS199C18","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1253\/circj.CJ-10-74-0802","article-title":"Japanese Circulation Society of Guidelines for Diagnosis and Treatment of Patients with Vasospastic Angina (Coronary Spastic Angina) (JCS2008)","volume":"74","author":"JCS Joint Working Group","year":"2010","journal-title":"Circ J"},{"key":"key\n\t\t\t\t20180328174257_EHS199C19","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1097\/00019501-200309000-00006","article-title":"Induction of coronary artery spasm by two pharmacological agents: comparison between intracoronary injection of acetylcholine and ergonovine","volume":"14","author":"Sueda","year":"2003","journal-title":"Coron Artery Dis"},{"issue":"Suppl","key":"key\n\t\t\t\t20180328174257_EHS199C20","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1291\/hypres.29.S1","article-title":"Japanese Society of Hypertension Guidelines Subcommittee for the Management of Hypertension. Japanese Society of Hypertension guidelines for the management of hypertension (JSH 2004)","volume":"29","year":"2006","journal-title":"Hypertens Res"},{"key":"key\n\t\t\t\t20180328174257_EHS199C21","doi-asserted-by":"crossref","first-page":"101","DOI":"10.5551\/jat.11.101","article-title":"Editorial: guidelines for diagnosis and treatment of atherosclerotic cardiovascular diseases 2002","volume":"11","author":"Saito","year":"2004","journal-title":"J Atheroscler Thromb"},{"key":"key\n\t\t\t\t20180328174257_EHS199C22","volume-title":"Japan Diabetes Society. Japan Diabetes Society of Guidelines for Treatment of Diabetes Mellitus 2006\u20132007 (in Japanese)","year":"2006"},{"key":"key\n\t\t\t\t20180328174257_EHS199C23","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1378\/chest.123.2.380","article-title":"Limitations of medical therapy in patients with pure coronary spastic angina","volume":"123","author":"Sueda","year":"2003","journal-title":"Chest"},{"key":"key\n\t\t\t\t20180328174257_EHS199C24","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1016\/j.amjcard.2009.12.013","article-title":"The first provocative test for coronary artery spasm at the Cleveland Clinic","volume":"105","author":"Siegel","year":"2010","journal-title":"Am J Cardiol"},{"key":"key\n\t\t\t\t20180328174257_EHS199C25","first-page":"1177","article-title":"Coronary artery spasm induced by the somministration of ergonovine maleate in subjects with spontaneous angina (author's transl)","volume":"6","author":"Specchia","year":"1976","journal-title":"G Ital Cardiol"},{"key":"key\n\t\t\t\t20180328174257_EHS199C26","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1161\/01.CIR.74.5.955","article-title":"Induction of coronary artery spasm by acetylcholine in patients with variant angina: possible role of the parasympathetic nervous system in the pathogenesis of coronary artery spasm","volume":"74","author":"Yasue","year":"1986","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20180328174257_EHS199C27","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/0735-1097(88)90449-4","article-title":"Sensitivity and specificity of intracoronary injection of acetylcholine for the induction of coronary artery spasm","volume":"12","author":"Okumura","year":"1988","journal-title":"J Am Coll Cardiol"},{"key":"key\n\t\t\t\t20180328174257_EHS199C28","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1161\/01.CIR.98.5.435","article-title":"Increased QT dispersion in patients with vasospastic angina","volume":"98","author":"Suzuki","year":"1998","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20180328174257_EHS199C29","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1161\/01.RES.67.3.615","article-title":"Differences in the electrophysiological response of canine ventricular subendocardium and subepicardium to acetylcholine and isoproterenol. A direct effect of acetylcholine in ventricular myocardium","volume":"67","author":"Litovsky","year":"1990","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20180328174257_EHS199C30","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.jacc.2011.11.015","article-title":"High prevalence of a pathological response to acetylcholine testing in patients with stable angina pectoris and unobstructed coronary arteries. The ACOVA Study (Abnormal COronary VAsomotion in patients with stable angina and unobstructed coronary arteries)","volume":"59","author":"Ong","year":"2012","journal-title":"J Am Coll Cardiol"},{"key":"key\n\t\t\t\t20180328174257_EHS199C31","doi-asserted-by":"crossref","DOI":"10.1007\/s00392-012-0442-4","article-title":"Increased coronary vasoconstrictor response to acetylcholine in women with chest pain and normal coronary arteriograms (cardiac syndrome X)","author":"Ong","year":"2012","journal-title":"Clin Res Cardiol"},{"key":"key\n\t\t\t\t20180328174257_EHS199C32","first-page":"H520","article-title":"Mathematical model of dependence of heart rate on tissue concentration of acetylcholine","volume":"256","author":"Dexter","year":"1989","journal-title":"Am J Physiol"},{"key":"key\n\t\t\t\t20180328174257_EHS199C33","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0167-5273(95)02478-6","article-title":"Increased constrictor response to acetylcholine of the isolated coronary arteries from patients with variant angina","volume":"52","author":"Kugiyama","year":"1995","journal-title":"Int J Cardiol"},{"key":"key\n\t\t\t\t20180328174257_EHS199C34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1253\/jcj.64.1","article-title":"Cellular and molecular mechanisms of coronary artery spasm: lessons from animal models","volume":"64","author":"Shimokawa","year":"2000","journal-title":"Jpn Circ J"},{"key":"key\n\t\t\t\t20180328174257_EHS199C35","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1097\/00005344-200011000-00013","article-title":"Modulation of contractions to ergonovine and methylergonovine by nitric oxide and thromboxane A2 in the human coronary artery","volume":"36","author":"Auch-Schwelk","year":"2000","journal-title":"J Cardiovasc Pharmacol"},{"key":"key\n\t\t\t\t20180328174257_EHS199C36","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.ijcard.2006.06.016","article-title":"Current clinical features, diagnostic assessment and prognostic determinants of patients with variant angina","volume":"118","author":"Lanza","year":"2007","journal-title":"Int J Cardiol"},{"key":"key\n\t\t\t\t20180328174257_EHS199C37","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1016\/j.amjcard.2005.11.073","article-title":"Location of focal vasospasm provoked by ergonovine maleate within coronary arteries in patients with vasospastic angina pectoris","volume":"97","author":"Koizumi","year":"2006","journal-title":"Am J Cardiol"},{"key":"key\n\t\t\t\t20180328174257_EHS199C38","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/0002-8703(95)90349-6","article-title":"Comparison of vessel wall morphologic appearance at sites of focal and diffuse coronary vasospasm by intravascular ultrasound","volume":"130","author":"Koyama","year":"1995","journal-title":"Am Heart J"},{"key":"key\n\t\t\t\t20180328174257_EHS199C39","doi-asserted-by":"crossref","first-page":"2446","DOI":"10.1161\/01.CIR.92.9.2446","article-title":"Progression and regression of coronary stenosis in the long-term follow-up of vasospastic angina","volume":"92","author":"Ozaki","year":"1995","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20180328174257_EHS199C40","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/S0735-1097(98)00520-8","article-title":"Histological evaluation of coronary plaque in patients with variant angina: relationship between vasospasm and neointimal hyperplasia in primary coronary lesions","volume":"33","author":"Suzuki","year":"1999","journal-title":"J Am Coll Cardiol"},{"key":"key\n\t\t\t\t20180328174257_EHS199C41","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1253\/circj.71.1383","article-title":"Clinical and angiographic characteristics of acute myocardial infarction caused by vasospastic angina without organic coronary heart disease","volume":"71","author":"Kim","year":"2007","journal-title":"Circ J"},{"key":"key\n\t\t\t\t20180328174257_EHS199C42","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1016\/S0735-1097(99)00073-X","article-title":"Racial heterogeneity in coronary artery vasomotor reactivity: differences between Japanese and Caucasian patients","volume":"33","author":"Beltrame","year":"1999","journal-title":"J Am Coll Cardiol"},{"key":"key\n\t\t\t\t20180328174257_EHS199C43","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1161\/01.CIR.101.10.1102","article-title":"Major racial differences in coronary constrictor response between Japanese and Caucasians with recent myocardial infarction","volume":"101","author":"Pristipino","year":"2000","journal-title":"Circulation"}],"container-title":["European Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/eurheartj\/article-pdf\/34\/4\/258\/17896929\/ehs199.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,30]],"date-time":"2019-06-30T16:13:54Z","timestamp":1561911234000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eurheartj\/article\/34\/4\/258\/429041"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7,10]]},"references-count":43,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2012,7,10]]},"published-print":{"date-parts":[[2013,1,21]]}},"URL":"https:\/\/doi.org\/10.1093\/eurheartj\/ehs199","relation":{},"ISSN":["1522-9645","0195-668X"],"issn-type":[{"value":"1522-9645","type":"electronic"},{"value":"0195-668X","type":"print"}],"subject":[],"published-other":{"date-parts":[[2013,1,21]]},"published":{"date-parts":[[2012,7,10]]}}}