{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T13:22:12Z","timestamp":1789132932727,"version":"build-2803163510"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"38","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Heart J"],"published-print":{"date-parts":[[2015,10,7]]},"DOI":"10.1093\/eurheartj\/ehv330","type":"journal-article","created":{"date-parts":[[2015,10,7]],"date-time":"2015-10-07T03:42:47Z","timestamp":1444189367000},"page":"2576-2584","source":"Crossref","is-referenced-by-count":200,"title":["Efficacy and safety of LCZ696 (sacubitril-valsartan) according to age: insights from PARADIGM-HF"],"prefix":"10.1093","volume":"36","author":[{"given":"Pardeep S.","family":"Jhund","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edmundo","family":"Bayram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Huan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Negrusz-Kawecka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arvo","family":"Rosenthal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akshay S.","family":"Desai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin P.","family":"Lefkowitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adel R.","family":"Rizkala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean L.","family":"Rouleau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor C.","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott D.","family":"Solomon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Swedberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Zile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.V.","family":"McMurray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milton","family":"Packer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,7,31]]},"reference":[{"key":"2016061402473002000_36.38.2576.1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001699"},{"key":"2016061402473002000_36.38.2576.2","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfq154"},{"key":"2016061402473002000_36.38.2576.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2013.04.008"},{"key":"2016061402473002000_36.38.2576.4","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.112.971119"},{"key":"2016061402473002000_36.38.2576.5","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hft052"},{"key":"2016061402473002000_36.38.2576.6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1409077"},{"key":"2016061402473002000_36.38.2576.7","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.013748"},{"key":"2016061402473002000_36.38.2576.8","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)00531-3"},{"key":"2016061402473002000_36.38.2576.9","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1815"},{"key":"2016061402473002000_36.38.2576.10","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1177\/1536867X0900900204","article-title":"Two techniques for investigating interactions between treatment and continuous covariates in clinical trials","volume":"9","author":"Royston","year":"2009","journal-title":"Stata J"},{"key":"2016061402473002000_36.38.2576.11","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehn476"},{"key":"2016061402473002000_36.38.2576.12","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hft102"},{"key":"2016061402473002000_36.38.2576.13","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.2000.2558"},{"key":"2016061402473002000_36.38.2576.14","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01442-5"},{"key":"2016061402473002000_36.38.2576.15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2012.06.095"},{"key":"2016061402473002000_36.38.2576.16","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hft028"},{"key":"2016061402473002000_36.38.2576.17","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-011-9263-1"},{"key":"2016061402473002000_36.38.2576.18","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp024"},{"key":"2016061402473002000_36.38.2576.19","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfr116"},{"key":"2016061402473002000_36.38.2576.20","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2011.31"},{"key":"2016061402473002000_36.38.2576.21","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehn539"},{"key":"2016061402473002000_36.38.2576.22","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2004.11.052"},{"key":"2016061402473002000_36.38.2576.23","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12141"},{"key":"2016061402473002000_36.38.2576.24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.04.086"},{"key":"2016061402473002000_36.38.2576.25","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.161.2.165"},{"key":"2016061402473002000_36.38.2576.26","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(96)90365-8"},{"key":"2016061402473002000_36.38.2576.27","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-011-9282-y"},{"key":"2016061402473002000_36.38.2576.28","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1P128"},{"key":"2016061402473002000_36.38.2576.29","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2006.05.012"},{"key":"2016061402473002000_36.38.2576.30","doi-asserted-by":"publisher","DOI":"10.1007\/s11897-013-0163-7"}],"container-title":["European Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/eurheartj\/article-pdf\/36\/38\/2576\/17154634\/ehv330.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,31]],"date-time":"2019-08-31T04:25:57Z","timestamp":1567225557000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eurheartj\/article-lookup\/doi\/10.1093\/eurheartj\/ehv330"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,31]]},"references-count":30,"journal-issue":{"issue":"38","published-online":{"date-parts":[[2015,10,7]]},"published-print":{"date-parts":[[2015,10,7]]}},"alternative-id":["10.1093\/eurheartj\/ehv330"],"URL":"https:\/\/doi.org\/10.1093\/eurheartj\/ehv330","relation":{},"ISSN":["0195-668X","1522-9645"],"issn-type":[{"value":"0195-668X","type":"print"},{"value":"1522-9645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,31]]}}}