{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T04:27:54Z","timestamp":1791952074939,"version":"4.3.4"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Heart J"],"published-print":{"date-parts":[[2016,2,7]]},"DOI":"10.1093\/eurheartj\/ehv563","type":"journal-article","created":{"date-parts":[[2015,11,18]],"date-time":"2015-11-18T02:29:16Z","timestamp":1447813756000},"page":"536-545","source":"Crossref","is-referenced-by-count":223,"title":["The impact of proprotein convertase subtilisin-kexin type 9 serine protease inhibitors on lipid levels and outcomes in patients with primary hypercholesterolaemia: a network meta-analysis"],"prefix":"10.1093","volume":"37","author":[{"given":"Michael J.","family":"Lipinski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umberto","family":"Benedetto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo O.","family":"Escarcega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Biondi-Zoccai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thibault","family":"Lhermusier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nevin C.","family":"Baker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Torguson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"H. Bryan","family":"Brewer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron","family":"Waksman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,11,17]]},"reference":[{"key":"2016020700322535000_37.6.536.1","doi-asserted-by":"crossref","unstructured":"Mega JL , Stitziel NO , Smith JG , Chasman DI , Caulfield MJ , Devlin JJ , Nordio F , Hyde CL , Cannon CP , Sacks FM , Poulter NR , Sever PS , Ridker PM , Braunwald E , Melander O , Kathiresan S , Sabatine MS . Genetic risk, coronary heart disease events, and the clinical benefit of statin therapy: an analysis of primary and secondary prevention trials. Lancet 2015; doi:10.1016\/S0140-6736(14)61730-X .","DOI":"10.1016\/S0140-6736(14)61730-X"},{"key":"2016020700322535000_37.6.536.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61350-5"},{"key":"2016020700322535000_37.6.536.3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0706628"},{"key":"2016020700322535000_37.6.536.4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1107579"},{"key":"2016020700322535000_37.6.536.5","doi-asserted-by":"crossref","unstructured":"Cannon CP , Blazing MA , Giugliano RP , McCagg A , White JA , Theroux P , Darius H , Lewis BS , Ophuis TO , Jukema JW , De Ferrari GM , Ruzyllo W , De Lucca P , Im K , Bohula EA , Reist C , Wiviott SD , Tershakovec AM , Musliner TA , Braunwald E , Califf RM . Ezetimibe added to statin therapy after acute coronary syndromes. N Engl J Med 2015, doi:10.1056\/NEJMoa1410489 .","DOI":"10.1056\/NEJMoa1410489"},{"key":"2016020700322535000_37.6.536.6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa054013"},{"key":"2016020700322535000_37.6.536.7","doi-asserted-by":"publisher","DOI":"10.1086\/500615"},{"key":"2016020700322535000_37.6.536.8","unstructured":"Higgins JPT , Altman DG , Sterne JAC . Chapter 8: assessing risk of bias in included studies. In: Higgins JPT , Green S , eds. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0: The Cochrane Collaboration , 2011. http:\/\/handbook.cochrane.org\/ (8 October 2015) ."},{"key":"2016020700322535000_37.6.536.9","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39489.470347.AD"},{"key":"2016020700322535000_37.6.536.10","doi-asserted-by":"publisher","DOI":"10.1002\/jrsm.1058"},{"key":"2016020700322535000_37.6.536.11","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-13-35"},{"key":"2016020700322535000_37.6.536.12","doi-asserted-by":"publisher","DOI":"10.1177\/096228029600500402"},{"key":"2016020700322535000_37.6.536.13","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.6.676"},{"key":"2016020700322535000_37.6.536.14","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.007012"},{"key":"2016020700322535000_37.6.536.15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.09.048"},{"key":"2016020700322535000_37.6.536.16","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.001969"},{"key":"2016020700322535000_37.6.536.17","doi-asserted-by":"publisher","DOI":"10.2217\/fca.14.82"},{"key":"2016020700322535000_37.6.536.18","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2014.05.060"},{"key":"2016020700322535000_37.6.536.19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.01.006"},{"key":"2016020700322535000_37.6.536.20","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.004678"},{"key":"2016020700322535000_37.6.536.21","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61374-X"},{"key":"2016020700322535000_37.6.536.22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.08.986"},{"key":"2016020700322535000_37.6.536.23","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1105803"},{"key":"2016020700322535000_37.6.536.24","doi-asserted-by":"crossref","unstructured":"Budha NR , Leabman M , Jin JY , Wada DR , Baruch A , Peng K , Tingley WG , Davis JD . Modeling and simulation to support phase 2 dose selection for RG7652, a fully human monoclonal antibody against proprotein convertase subtilisin\/kexin type 9. AAPS J 2015, doi:10.1208\/s12248-015-9750-8 .","DOI":"10.1208\/s12248-015-9750-8"},{"key":"2016020700322535000_37.6.536.25","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2014.07.028"},{"key":"2016020700322535000_37.6.536.26","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2014.09.007"},{"key":"2016020700322535000_37.6.536.27","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1201832"},{"key":"2016020700322535000_37.6.536.28","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1316222"},{"key":"2016020700322535000_37.6.536.29","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.25790"},{"key":"2016020700322535000_37.6.536.30","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.03.019"},{"key":"2016020700322535000_37.6.536.31","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61770-X"},{"key":"2016020700322535000_37.6.536.32","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.4030"},{"key":"2016020700322535000_37.6.536.33","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.03.007"},{"key":"2016020700322535000_37.6.536.34","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61771-1"},{"key":"2016020700322535000_37.6.536.35","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.03.018"},{"key":"2016020700322535000_37.6.536.36","doi-asserted-by":"crossref","unstructured":"Kereiakes DJ , Robinson JG , Cannon CP , Lorenzato C , Pordy R , CHaudhari U , Colhoun HM . Efficacy and safety of the PCSK9 inhibitor alirocumab among high cardiovascular risk patients on maximally tolerated statin therapy: the ODYSSEY COMBO I study. Am Heart J 2015, doi:10.1016\/j.ahj.2015.03.004 .","DOI":"10.1016\/j.ahj.2015.03.004"},{"key":"2016020700322535000_37.6.536.37","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv028"},{"key":"2016020700322535000_37.6.536.38","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1501031"},{"key":"2016020700322535000_37.6.536.39","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2014.06.049"},{"key":"2016020700322535000_37.6.536.40","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1500858"},{"key":"2016020700322535000_37.6.536.41","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.144055"},{"key":"2016020700322535000_37.6.536.42","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61399-4"},{"key":"2016020700322535000_37.6.536.43","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60771-5"},{"key":"2016020700322535000_37.6.536.44","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-14-0130"},{"key":"2016020700322535000_37.6.536.45","doi-asserted-by":"publisher","DOI":"10.7326\/M14-2957"},{"key":"2016020700322535000_37.6.536.46","doi-asserted-by":"publisher","DOI":"10.1038\/ng1161"},{"key":"2016020700322535000_37.6.536.47","doi-asserted-by":"publisher","DOI":"10.1172\/JCI29383"}],"container-title":["European Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/eurheartj\/article-pdf\/37\/6\/536\/17357540\/ehv563.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,8,24]],"date-time":"2017-08-24T13:37:28Z","timestamp":1503581848000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eurheartj\/article-lookup\/doi\/10.1093\/eurheartj\/ehv563"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,17]]},"references-count":47,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2016,2,7]]},"published-print":{"date-parts":[[2016,2,7]]}},"alternative-id":["10.1093\/eurheartj\/ehv563"],"URL":"https:\/\/doi.org\/10.1093\/eurheartj\/ehv563","relation":{},"ISSN":["0195-668X","1522-9645"],"issn-type":[{"value":"0195-668X","type":"print"},{"value":"1522-9645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,17]]}}}