{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T18:01:47Z","timestamp":1793642507922,"version":"4.5.1"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"17","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,5,1]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>ASSERT demonstrated that subclinical atrial fibrillation (SCAF) is common in pacemaker patients without prior AF and is associated with increased risk of ischemic stroke or systemic embolism. SCAF episodes vary in duration and little is known about the incidence of different durations of SCAF, or their prognosis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>ASSERT followed 2580 patients receiving a pacemaker or ICD, aged &amp;gt;65 years with hypertension, without prior AF. The effect of SCAF duration on subsequent risk of ischemic stroke or embolism was evaluated with time-dependent covariate Cox models. Patients in whom the longest SCAF was\u2009\u22646\u2009min were excluded from the analysis (n=125). Among 2455 patients during mean follow-up of 2.5 years, the longest single episode of SCAF lasted &amp;gt;6\u2009min to 6\u2009h in 462 patients (18.8%), &amp;gt;6\u201324\u2009h in 169 (6.9%), and &amp;gt;24\u2009h in 262 (10.7%). SCAF duration &amp;gt;24\u2009h was associated with a significant increased risk of subsequent stroke or systemic embolism (adjusted hazard ratio [HR] 3.24, 95% confidence interval [CI] 1.51\u20136.95, P=0.003). The risk of ischemic stroke or systemic embolism in patients with SCAF between 6\u2009min and 24\u2009h was not significantly different from patients without SCAF.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>SCAF &amp;gt;24\u2009h is associated with an increased risk of ischemic stroke or systemic embolism.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/eurheartj\/ehx042","type":"journal-article","created":{"date-parts":[[2017,1,30]],"date-time":"2017-01-30T13:27:49Z","timestamp":1485782869000},"page":"1339-1344","source":"Crossref","is-referenced-by-count":554,"title":["Duration of device-detected subclinical atrial fibrillation and occurrence of stroke in ASSERT"],"prefix":"10.1093","volume":"38","author":[{"given":"Isabelle C.","family":"Van Gelder","sequence":"first","affiliation":[{"name":"1Department of Cardiology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff S.","family":"Healey","sequence":"additional","affiliation":[{"name":"2Population Health Research Institute, McMaster University, 237 Barton Street East, Hamilton, ON L8L 2X2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry J.G.M.","family":"Crijns","sequence":"additional","affiliation":[{"name":"3Department of Cardiology, Maastricht University Medical Centre, Cardiovascular Research Institute Maastricht (CARIM), P. Debyelaan 25, 6202 AZ Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Wang","sequence":"additional","affiliation":[{"name":"2Population Health Research Institute, McMaster University, 237 Barton Street East, Hamilton, ON L8L 2X2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan H.","family":"Hohnloser","sequence":"additional","affiliation":[{"name":"4Department of Cardiology, J.W. Goethe University, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Gold","sequence":"additional","affiliation":[{"name":"5Division of Cardiology, Medical University of South Carolina, 114 Doughty Street, MSC 592, Charleston, SC 29425-5920, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Capucci","sequence":"additional","affiliation":[{"name":"6Clinica di Cardiologia, Universit\u00e0 Politecnica delle Marche, Via Conca 71, Ancona 60126, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chu-Pak","family":"Lau","sequence":"additional","affiliation":[{"name":"7Cardiology Division, Queen Mary Hospital, University of Hong Kong, 102 Pokfulam Road, Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos A.","family":"Morillo","sequence":"additional","affiliation":[{"name":"2Population Health Research Institute, McMaster University, 237 Barton Street East, Hamilton, ON L8L 2X2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne H.","family":"Hobbelt","sequence":"additional","affiliation":[{"name":"1Department of Cardiology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiel","family":"Rienstra","sequence":"additional","affiliation":[{"name":"1Department of Cardiology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart J.","family":"Connolly","sequence":"additional","affiliation":[{"name":"2Population Health Research Institute, McMaster University, 237 Barton Street East, Hamilton, ON L8L 2X2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,3,1]]},"reference":[{"key":"2022102517425202700_ehx042-B1","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1093\/eurheartj\/ehw210","article-title":"ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS: the Task Force for the management of atrial fibrillation of the European Society of Cardiology (ESC)","volume":"37","author":"Kirchhof","year":"2016","journal-title":"Eur Heart J"},{"key":"2022102517425202700_ehx042-B2","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.jacc.2015.06.1314","article-title":"Incidence of atrial fibrillation and relationship with cardiovascular events, heart failure, and mortality:","volume":"66","author":"Vermond","year":"2015","journal-title":"a community-based study from the Netherlands. 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