{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T19:57:48Z","timestamp":1792612668031,"version":"4.5.0"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"20","license":[{"start":{"date-parts":[[2018,1,30]],"date-time":"2018-01-30T00:00:00Z","timestamp":1517270400000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/academic.oup.com\/journals\/pages\/about_us\/legal\/notices"}],"funder":[{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["R-172-003-219-511"],"award-info":[{"award-number":["R-172-003-219-511"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,5,21]]},"DOI":"10.1093\/eurheartj\/ehy005","type":"journal-article","created":{"date-parts":[[2018,1,11]],"date-time":"2018-01-11T22:04:29Z","timestamp":1515708269000},"page":"1770-1780","source":"Crossref","is-referenced-by-count":275,"title":["Mortality associated with heart failure with preserved vs. reduced ejection fraction in a prospective international multi-ethnic cohort study"],"prefix":"10.1093","volume":"39","author":[{"given":"Carolyn S P","family":"Lam","sequence":"first","affiliation":[{"name":"Cardiovascular Research Institute, National University Health System, 1E Kent Ridge Road, Singapore 119228"},{"name":"National Heart Centre Singapore and Duke-National University of Singapore, 5 Hospital Drive, Singapore 169609"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg D","family":"Gamble","sequence":"additional","affiliation":[{"name":"Heart Health Research Group, University of Auckland, Park Road, Grafton, Auckland 1023, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lieng H","family":"Ling","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute, National University Health System, 1E Kent Ridge Road, Singapore 119228"},{"name":"National Heart Centre Singapore and Duke-National University of Singapore, 5 Hospital Drive, Singapore 169609"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Sim","sequence":"additional","affiliation":[{"name":"National Heart Centre Singapore and Duke-National University of Singapore, 5 Hospital Drive, Singapore 169609"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kui Toh Gerard","family":"Leong","sequence":"additional","affiliation":[{"name":"Changi General Hospital, 2 Simei Street 3, Singapore 529889"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poh Shuan Daniel","family":"Yeo","sequence":"additional","affiliation":[{"name":"Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore 308433"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hean Yee","family":"Ong","sequence":"additional","affiliation":[{"name":"Khoo Teck Puat Hospital, 90 Yishun Central, Singapore 768828"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fazlur","family":"Jaufeerally","sequence":"additional","affiliation":[{"name":"Singapore General Hospital, Outram Road, Singapore 169608"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tze P","family":"Ng","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Road Singapore, Singapore 119228"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicky A","family":"Cameron","sequence":"additional","affiliation":[{"name":"Christchurch Heart Institute, University of Otago, 2 Riccarton Avenue, Christchurch 8011, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrina","family":"Poppe","sequence":"additional","affiliation":[{"name":"Heart Health Research Group, University of Auckland, Park Road, Grafton, Auckland 1023, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayanna","family":"Lund","sequence":"additional","affiliation":[{"name":"Middlemore Hospital, 100 Hospital Road, Otahuhu, Auckland 2025, NZ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerry","family":"Devlin","sequence":"additional","affiliation":[{"name":"Waikato Hospital, Pembroke Street, Hamilton 3204, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Troughton","sequence":"additional","affiliation":[{"name":"Christchurch Heart Institute, University of Otago, 2 Riccarton Avenue, Christchurch 8011, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A Mark","family":"Richards","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute, National University Health System, 1E Kent Ridge Road, Singapore 119228"},{"name":"Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Road Singapore, Singapore 119228"},{"name":"Christchurch Heart Institute, University of Otago, 2 Riccarton Avenue, Christchurch 8011, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert N","family":"Doughty","sequence":"additional","affiliation":[{"name":"Heart Health Research Group, University of Auckland, Park Road, Grafton, Auckland 1023, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,1,29]]},"reference":[{"key":"key\n\t\t\t\t20180521065608_ehy005-B1","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1056\/NEJMoa052256","article-title":"Trends in prevalence and outcome of heart failure with preserved ejection fraction","volume":"355","author":"Owan","year":"2006","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20180521065608_ehy005-B2","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1056\/NEJMoa051530","article-title":"Outcome of heart failure with preserved ejection fraction in a population-based study","volume":"355","author":"Bhatia","year":"2006","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20180521065608_ehy005-B3","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1093\/aje\/kwt109","article-title":"Contemporary trends in heart failure with reduced and preserved ejection fraction after myocardial infarction: a community study","volume":"178","author":"Gerber","year":"2013","journal-title":"Am J Epidemiol"},{"key":"key\n\t\t\t\t20180521065608_ehy005-B4","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1093\/eurheartj\/ehr254","article-title":"The survival of patients with heart failure with preserved or reduced left ventricular ejection fraction: an individual patient data meta-analysis","volume":"33","author":"MAGGIC Collaborative Group","year":"2012","journal-title":"Eur Heart J"},{"key":"key\n\t\t\t\t20180521065608_ehy005-B5","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1093\/eurjhf\/hft062","article-title":"How do patients with heart failure with preserved ejection fraction die?","volume":"15","author":"Chan","year":"2013","journal-title":"Eur J Heart Fail"},{"key":"key\n\t\t\t\t20180521065608_ehy005-B6","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1056\/NEJMc076179","article-title":"Prognosis in heart failure with a normal ejection fraction","volume":"357","author":"Cleland","year":"2007","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20180521065608_ehy005-B7","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1093\/eurjhf\/hft101","article-title":"Known and missing left ventricular ejection fraction and survival in patients with heart failure: a MAGGIC meta-analysis report","volume":"15","author":"Poppe","year":"2013","journal-title":"Eur J Heart Fail"},{"key":"key\n\t\t\t\t20180521065608_ehy005-B8","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.cardfail.2013.01.007","article-title":"The Singapore Heart Failure Outcomes and Phenotypes (SHOP) study and Prospective Evaluation of Outcome in Patients with Heart Failure with Preserved Left Ventricular Ejection Fraction (PEOPLE) study: rationale and design","volume":"19","author":"Santhanakrishnan","year":"2013","journal-title":"J Card Fail"},{"key":"key\n\t\t\t\t20180521065608_ehy005-B9","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1093\/eurheartj\/ehs104","article-title":"ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC","volume":"33","author":"McMurray","year":"2012","journal-title":"Eur Heart J"},{"key":"key\n\t\t\t\t20180521065608_ehy005-B10","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1093\/eurheartj\/ehw128","article-title":"2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failureThe Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC)Developed with the special contribution of the Heart Failure Association (HFA) of the ESC","volume":"37","author":"Ponikowski","year":"2016","journal-title":"Eur Heart J"},{"key":"key\n\t\t\t\t20180521065608_ehy005-B11","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1093\/eurjhf\/hfp103","article-title":"The prognostic significance of heart failure with preserved left ventricular ejection fraction: a literature-based meta-analysis","volume":"11","author":"Somaratne","year":"2009","journal-title":"Eur J Heart Fail"},{"key":"key\n\t\t\t\t20180521065608_ehy005-B12","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/S0140-6736(03)14285-7","article-title":"Effects of candesartan in patients with chronic heart failure and preserved left-ventricular ejection fraction: the CHARM-Preserved Trial","volume":"362","author":"Yusuf","year":"2003","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20180521065608_ehy005-B13","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1056\/NEJMoa0805450","article-title":"Irbesartan in patients with heart failure and preserved ejection fraction","volume":"359","author":"Massie","year":"2008","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20180521065608_ehy005-B14","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1136\/heartjnl-2015-307782","article-title":"Prognostic value of NT-proBNP in heart failure with preserved versus reduced EF","volume":"101","author":"Kang","year":"2015","journal-title":"Heart"},{"key":"key\n\t\t\t\t20180521065608_ehy005-B15","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1093\/eurheartj\/ehi631","article-title":"NT-proBNP testing for diagnosis and short-term prognosis in acute destabilized heart failure: an international pooled analysis of 1256 patients: the International Collaborative of NT-proBNP Study","volume":"27","author":"Januzzi","year":"2006","journal-title":"Eur Heart J"},{"key":"key\n\t\t\t\t20180521065608_ehy005-B16","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1016\/j.jacc.2012.12.044","article-title":"B-type natriuretic peptide and prognosis in heart failure patients with preserved and reduced ejection fraction","volume":"61","author":"van Veldhuisen","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"key\n\t\t\t\t20180521065608_ehy005-B17","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1093\/eurjhf\/hfs049","article-title":"Relationship between plasma concentrations of N-terminal pro brain natriuretic peptide and the characteristics and outcome of patients with a clinical diagnosis of diastolic heart failure: a report from the PEP-CHF study","volume":"14","author":"Cleland","year":"2012","journal-title":"Eur J Heart Fail"},{"key":"key\n\t\t\t\t20180521065608_ehy005-B18","first-page":"569","article-title":"Prognostic value of baseline plasma amino-terminal pro-brain natriuretic peptide and its interactions with irbesartan treatment effects in patients with heart failure and preserved ejection fraction: findings from the I-PRESERVE trial","volume":"4","author":"Anand","year":"2011","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20180521065608_ehy005-B19","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1016\/j.jacc.2007.02.037","article-title":"Admission B-type natriuretic peptide levels and in-hospital mortality in acute decompensated heart failure","volume":"49","author":"Fonarow","year":"2007","journal-title":"J Am Coll Cardiol"},{"key":"key\n\t\t\t\t20180521065608_ehy005-B20","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.jacc.2005.11.030","article-title":"B-type natriuretic peptide strongly reflects diastolic wall stress in patients with chronic heart failure: comparison between systolic and diastolic heart failure","volume":"47","author":"Iwanaga","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"key\n\t\t\t\t20180521065608_ehy005-B21","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1056\/NEJMoa1313731","article-title":"Spironolactone for heart failure with preserved ejection fraction","volume":"370","author":"Pitt","year":"2014","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20180521065608_ehy005-B22","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.ahj.2014.07.008","article-title":"Outcomes in patients with heart failure with preserved, borderline, and reduced ejection fraction in the Medicare population","volume":"168","author":"Cheng","year":"2014","journal-title":"Am Heart J"},{"key":"key\n\t\t\t\t20180521065608_ehy005-B23","first-page":"e003875.","article-title":"Significance of ischemic heart disease in patients with heart failure and preserved, midrange, and reduced ejection fraction: a nationwide cohort study","volume":"10","author":"Vedin","year":"2017","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20180521065608_ehy005-B24","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1002\/ejhf.566","article-title":"European Society of Cardiology Heart Failure Long-Term Registry (ESC-HF-LT): 1-year follow-up outcomes and differences across regions","volume":"18","author":"Crespo-Leiro","year":"2016","journal-title":"Eur J Heart Fail"},{"key":"key\n\t\t\t\t20180521065608_ehy005-B25","doi-asserted-by":"crossref","first-page":"3141","DOI":"10.1093\/eurheartj\/ehw331","article-title":"Regional and ethnic differences among patients with heart failure in Asia: the Asian sudden cardiac death in heart failure registry","volume":"37","author":"Lam","year":"016","journal-title":"Eur Heart J 2"},{"key":"key\n\t\t\t\t20180521065608_ehy005-B26","first-page":"429","article-title":"The Hospitalization Burden and Post-Hospitalization Mortality Risk in Heart Failure With Preserved Ejection Fraction: Results From the I-PRESERVE Trial (Irbesartan in Heart Failure and Preserved Ejection Fraction)","volume":"3","author":"Carson","year":"2015","journal-title":"JACC"},{"key":"key\n\t\t\t\t20180521065608_ehy005-B27","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1002\/ejhf.890","article-title":"Clinical phenotypes and outcome of patients hospitalized for acute heart failure: the ESC Heart Failure Long-Term Registry","volume":"19","author":"Chioncel","year":"2017","journal-title":"Eur J Heart Fail"}],"container-title":["European Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/eurheartj\/article-pdf\/39\/20\/1770\/24836608\/ehy005.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,9]],"date-time":"2019-10-09T04:29:38Z","timestamp":1570595378000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eurheartj\/article\/39\/20\/1770\/4829677"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,29]]},"references-count":27,"journal-issue":{"issue":"20","published-online":{"date-parts":[[2018,1,29]]},"published-print":{"date-parts":[[2018,5,21]]}},"URL":"https:\/\/doi.org\/10.1093\/eurheartj\/ehy005","relation":{},"ISSN":["0195-668X","1522-9645"],"issn-type":[{"value":"0195-668X","type":"print"},{"value":"1522-9645","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,5,21]]},"published":{"date-parts":[[2018,1,29]]}}}