{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T03:02:52Z","timestamp":1794020572925,"version":"4.8.0"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"30","license":[{"start":{"date-parts":[[2018,5,19]],"date-time":"2018-05-19T00:00:00Z","timestamp":1526688000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/about_us\/legal\/notices"}],"funder":[{"name":"Mayo Clinic and Foundation"},{"DOI":"10.13039\/100008732","name":"Uehara Memorial Foundation","doi-asserted-by":"publisher","award":["RO1 HL126638"],"award-info":[{"award-number":["RO1 HL126638"]}],"id":[{"id":"10.13039\/100008732","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008732","name":"Uehara Memorial Foundation","doi-asserted-by":"publisher","award":["T32 HL007111.V.M"],"award-info":[{"award-number":["T32 HL007111.V.M"]}],"id":[{"id":"10.13039\/100008732","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Czech Healthcare Research","award":["17-28784A"],"award-info":[{"award-number":["17-28784A"]}]},{"name":"Czech Healthcare Research","award":["RO1 HL128526"],"award-info":[{"award-number":["RO1 HL128526"]}]},{"name":"Czech Healthcare Research","award":["RO1 HL126638"],"award-info":[{"award-number":["RO1 HL126638"]}]},{"name":"Czech Healthcare Research","award":["UO1 HL125205"],"award-info":[{"award-number":["UO1 HL125205"]}]},{"name":"Czech Healthcare Research","award":["U10 HL110262"],"award-info":[{"award-number":["U10 HL110262"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,8,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Increases in left ventricular filling pressure are a fundamental haemodynamic abnormality in heart failure with preserved ejection fraction (HFpEF). However, very little is known regarding how elevated filling pressures cause pulmonary abnormalities or symptoms of dyspnoea. We sought to determine the relationships between simultaneously measured central haemodynamics, symptoms, and lung ventilatory and gas exchange abnormalities during exercise in HFpEF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Subjects with invasively-proven HFpEF (n\u2009=\u200950) and non-cardiac causes of dyspnoea (controls, n\u2009=\u200924) underwent cardiac catheterization at rest and during exercise with simultaneous expired gas analysis. During submaximal (20 W) exercise, subjects with HFpEF displayed higher pulmonary capillary wedge pressures (PCWP) and pulmonary artery pressures, higher Borg perceived dyspnoea scores, and increased ventilatory drive and respiratory rate. At peak exercise, ventilation reserve was reduced in HFpEF compared with controls, with greater dead space ventilation (higher VD\/VT). Increasing exercise PCWP was directly correlated with higher perceived dyspnoea scores, lower peak exercise capacity, greater ventilatory drive, worse New York Heart Association (NYHA) functional class, and impaired pulmonary ventilation reserve.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study provides the first evidence linking altered exercise haemodynamics to pulmonary abnormalities and symptoms of dyspnoea in patients with HFpEF. Further study is required to identify the mechanisms by which haemodynamic derangements affect lung function and symptoms and to test novel therapies targeting exercise haemodynamics in HFpEF.<\/jats:p>\n                    <jats:p\/>\n                  <\/jats:sec>","DOI":"10.1093\/eurheartj\/ehy268","type":"journal-article","created":{"date-parts":[[2018,4,30]],"date-time":"2018-04-30T15:10:22Z","timestamp":1525101022000},"page":"2810-2821","source":"Crossref","is-referenced-by-count":253,"title":["Haemodynamics, dyspnoea, and pulmonary reserve in heart failure with preserved ejection fraction"],"prefix":"10.1093","volume":"39","author":[{"given":"Masaru","family":"Obokata","sequence":"first","affiliation":[{"name":"The Department of Cardiovascular Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas P","family":"Olson","sequence":"additional","affiliation":[{"name":"The Department of Cardiovascular Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yogesh N V","family":"Reddy","sequence":"additional","affiliation":[{"name":"The Department of Cardiovascular Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vojtech","family":"Melenovsky","sequence":"additional","affiliation":[{"name":"The Department of Cardiovascular Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garvan C","family":"Kane","sequence":"additional","affiliation":[{"name":"The Department of Cardiovascular Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry A","family":"Borlaug","sequence":"additional","affiliation":[{"name":"The Department of Cardiovascular Medicine, Mayo Clinic, 200 First Street SW, 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