{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T15:08:08Z","timestamp":1793718488578,"version":"4.6.1"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"33","license":[{"start":{"date-parts":[[2018,6,5]],"date-time":"2018-06-05T00:00:00Z","timestamp":1528156800000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/academic.oup.com\/journals\/pages\/about_us\/legal\/notices"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004807","name":"DFG","doi-asserted-by":"publisher","award":["TTR 219 (S-01)"],"award-info":[{"award-number":["TTR 219 (S-01)"]}],"id":[{"id":"10.13039\/100004807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,9,1]]},"DOI":"10.1093\/eurheartj\/ehy287","type":"journal-article","created":{"date-parts":[[2018,5,3]],"date-time":"2018-05-03T07:19:58Z","timestamp":1525331998000},"page":"3105-3114","source":"Crossref","is-referenced-by-count":118,"title":["Achieved diastolic blood pressure and pulse pressure at target systolic blood pressure (120\u2013140 mmHg) and cardiovascular outcomes in high-risk patients: results from ONTARGET and TRANSCEND trials"],"prefix":"10.1093","volume":"39","author":[{"given":"Michael","family":"B\u00f6hm","sequence":"first","affiliation":[{"name":"Klinik f\u00fcr Innere Medizin III, Universit\u00e4tsklinikum des Saarlandes, 66421 Homburg\/Saar, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helmut","family":"Schumacher","sequence":"additional","affiliation":[{"name":"Statistical Consultant, 55216 Ingelheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koon K","family":"Teo","sequence":"additional","affiliation":[{"name":"Population Health Research Institute, McMaster University, Hamilton, ON L8L 2X2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Lonn","sequence":"additional","affiliation":[{"name":"Population Health Research Institute, McMaster University, Hamilton, ON L8L 2X2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Mahfoud","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Innere Medizin III, Universit\u00e4tsklinikum des Saarlandes, 66421 Homburg\/Saar, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes F E","family":"Mann","sequence":"additional","affiliation":[{"name":"KfH Kidney Center, 80804 Munich-Schwabing and Department of Nephrology and Hypertension, University Hospital, Friedrich-Alexander University, 91054 Erlangen\/Nuremberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Mancia","sequence":"additional","affiliation":[{"name":"Istituto Clinico Universitario Policlinico di Monza, Universit\u00e0 degli Studi di Milano Bicocca, Piazza dell'Ateneo Nuovo, 1, 20126 Milano MI, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep","family":"Redon","sequence":"additional","affiliation":[{"name":"Hypertension Unit, Hospital Cl\u00ednico Universitario, Av. de Blasco Ib\u00e1\u00f1ez, 13, 46010 Val\u00e8ncia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Schmieder","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension, University Hospital, Friedrich-Alexander University, 91054 Erlangen\/Nuremberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Weber","sequence":"additional","affiliation":[{"name":"Downstate College of Medicine, State University of New York, 450 Clarkson Ave, Brooklyn, NY 11203, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Sliwa","sequence":"additional","affiliation":[{"name":"Hatter Institute for Cardiovascular Research in Africa & IIDMM, Faculty of Health Sciences, University of Cape Town, Private Bag X3 7935, Observatory, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan","family":"Williams","sequence":"additional","affiliation":[{"name":"University College London (UCL) Institute of Cardiovascular Science and National Institute for Health Research (NIHR) UCL Hospitals Biomedical Research Centre, 149 Tottenham Court Road, London W1T 7DN, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salim","family":"Yusuf","sequence":"additional","affiliation":[{"name":"Population Health Research Institute, McMaster University, Hamilton, ON L8L 2X2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,6,4]]},"reference":[{"key":"key\n\t\t\t\t20180904104126_ehy287-B1","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0140-6736(05)17741-1","article-title":"Global burden of hypertension: analysis of worldwide data","volume":"365","author":"Kearney","year":"2005","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20180904104126_ehy287-B2","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0140-6736(14)61682-2","article-title":"Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013","volume":"385","author":"GBD 2013 Mortality and Causes of Death Collaborators","year":"2015","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20180904104126_ehy287-B3","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1093\/eurheartj\/eht151","article-title":"2013 ESH\/ESC Guidelines for the management of arterial hypertension: the Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC)","volume":"34","author":"Mancia","year":"2013","journal-title":"Eur Heart J"},{"key":"key\n\t\t\t\t20180904104126_ehy287-B4","doi-asserted-by":"crossref","first-page":"3035","DOI":"10.1093\/eurheartj\/eht108","article-title":"ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD: the Task Force on diabetes, pre-diabetes, and cardiovascular diseases of the European Society of Cardiology (ESC) and developed in collaboration with the European Association for the Study of Diabetes (EASD)","volume":"34","author":"Ryd\u00e9n","year":"2013","journal-title":"Eur Heart J"},{"key":"key\n\t\t\t\t20180904104126_ehy287-B5","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1001\/jama.2013.284427","article-title":"2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8)","volume":"311","author":"James","year":"2014","journal-title":"Jama"},{"key":"key\n\t\t\t\t20180904104126_ehy287-B6","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1177\/1740774514537404","article-title":"The design and rationale of a multicenter clinical trial comparing two strategies for control of systolic blood pressure: the Systolic Blood Pressure Intervention Trial (SPRINT)","volume":"11","author":"Ambrosius","year":"2014","journal-title":"Clin Trials"},{"key":"key\n\t\t\t\t20180904104126_ehy287-B7","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1056\/NEJMoa1001286","article-title":"Effects of intensive blood-pressure control in type 2 diabetes mellitus","volume":"362","author":"Cushman","year":"2010","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20180904104126_ehy287-B8","doi-asserted-by":"crossref","first-page":"884","DOI":"10.7326\/0003-4819-144-12-200606200-00005","article-title":"Dogma disputed: can aggressively lowering blood pressure in hypertensive patients with coronary artery disease be dangerous?","volume":"144","author":"Messerli","year":"2006","journal-title":"Ann Intern Med"},{"key":"key\n\t\t\t\t20180904104126_ehy287-B9","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1001\/jama.2010.884","article-title":"Tight blood pressure control and cardiovascular outcomes among hypertensive patients with diabetes and coronary artery disease","volume":"304","author":"Cooper-DeHoff","year":"2010","journal-title":"Jama"},{"key":"key\n\t\t\t\t20180904104126_ehy287-B10","doi-asserted-by":"crossref","DOI":"10.1016\/S0140-6736(16)31326-5","article-title":"Cardiovascular event rates and mortality according to achieved systolic and diastolic blood pressure in patients with stable coronary artery disease: an international cohort study","author":"Vidal-Petiot","year":"2016","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20180904104126_ehy287-B11","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.1016\/S0140-6736(17)30754-7","article-title":"Achieved blood pressure and cardiovascular outcomes in high-risk patients: results from ONTARGET and TRANSCEND trials","volume":"389","author":"B\u00f6hm","year":"2017","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20180904104126_ehy287-B12","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCULATIONAHA.117.027362","article-title":"Incident cardiovascular disease among adults with blood pressure < 140\/90 mmHg","author":"Tajeu","year":"2017","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20180904104126_ehy287-B13","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1056\/NEJMoa0801317","article-title":"Telmisartan, ramipril, or both in patients at high risk for vascular events","volume":"358","author":"Yusuf","year":"2008","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20180904104126_ehy287-B14","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1016\/S0140-6736(08)61242-8","article-title":"Effects of the angiotensin-receptor blocker telmisartan on cardiovascular events in high-risk patients intolerant to angiotensin-converting enzyme inhibitors: a randomised controlled trial","volume":"372","author":"Yusuf","year":"2008","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20180904104126_ehy287-B15","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1002\/sim.4780080504","article-title":"Flexible regression models with cubic splines","volume":"8","author":"Durrleman","year":"1989","journal-title":"Stat Med"},{"key":"key\n\t\t\t\t20180904104126_ehy287-B16","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1136\/bmj.2.3679.43","article-title":"A British Medical Association Lecture on the significance of a raised blood pressure","volume":"2","author":"Hay","year":"1931","journal-title":"Br Med J"},{"key":"key\n\t\t\t\t20180904104126_ehy287-B17","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/0002-9149(71)90428-0","article-title":"Systolic versus diastolic blood pressure and risk of coronary heart disease. The Framingham study","volume":"27","author":"Kannel","year":"1971","journal-title":"Am J Cardiol"},{"key":"key\n\t\t\t\t20180904104126_ehy287-B18","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1161\/01.CIR.54.1.51","article-title":"A study of comparative blood pressure measures in predicting risk of coronary heart disease","volume":"54","author":"Rosenman","year":"1976","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20180904104126_ehy287-B19","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1016\/S0140-6736(14)60685-1","article-title":"Blood pressure and incidence of twelve cardiovascular diseases: lifetime risks, healthy life-years lost, and age-specific associations in 125 million people","volume":"383","author":"Rapsomaniki","year":"2014","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20180904104126_ehy287-B20","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1056\/NEJMoa1600175","article-title":"Blood-pressure lowering in intermediate-risk persons without cardiovascular disease","volume":"374","author":"Lonn","year":"2016","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20180904104126_ehy287-B21","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1161\/HYPERTENSIONAHA.113.01922","article-title":"Aggressive blood pressure lowering is dangerous: the J-curve: pro side of the argument","volume":"63","author":"Mancia","year":"2014","journal-title":"Hypertension"},{"key":"key\n\t\t\t\t20180904104126_ehy287-B22","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1016\/j.jacc.2009.05.073","article-title":"The J-curve between blood pressure and coronary artery disease or essential hypertension: exactly how essential?","volume":"54","author":"Messerli","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"key\n\t\t\t\t20180904104126_ehy287-B23","volume-title":"Cardiovascular Physiology","author":"Levy","year":"2001","edition":"8"},{"key":"key\n\t\t\t\t20180904104126_ehy287-B24","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1016\/j.jacc.2016.07.754","article-title":"Diastolic blood pressure, subclinical myocardial damage, and cardiac events: implications for blood pressure control","volume":"68","author":"McEvoy","year":"2016","journal-title":"J Am Coll Cardiol"},{"key":"key\n\t\t\t\t20180904104126_ehy287-B25","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/sj.jhh.1001461","article-title":"Pulse pressure and coronary mortality in elderly men and women from general population","volume":"16","author":"Casiglia","year":"2002","journal-title":"J Hum Hypertens"},{"key":"key\n\t\t\t\t20180904104126_ehy287-B26","doi-asserted-by":"crossref","DOI":"10.1093\/eurheartj\/ehx809","article-title":". Blood pressure and cardiovascular outcomes in patients with diabetes and high cardiovascular risk","author":"Bergmark","year":"2018","journal-title":"Eur Heart J"},{"key":"key\n\t\t\t\t20180904104126_ehy287-B27","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1097\/HJH.0b013e32835f7e2b","article-title":"Isolated systolic hypertension: \u2018to treat or not to treat\u2019 and the role of central haemodynamics","volume":"31","author":"Protogerou","year":"2013","journal-title":"J Hypertens"},{"key":"key\n\t\t\t\t20180904104126_ehy287-B28","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1161\/01.CIR.0000105767.94169.E3","article-title":"Arterial stiffness, wave reflections, and the risk of coronary artery disease","volume":"109","author":"Weber","year":"2004","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20180904104126_ehy287-B29","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1161\/01.CIR.0000136582.33493.CC","article-title":"Relationship between arterial stiffness and subclinical aortic atherosclerosis","volume":"110","author":"Herrington","year":"2004","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20180904104126_ehy287-B30","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1001\/archinte.160.8.1085","article-title":"Pulse pressure not mean pressure determines cardiovascular risk in older hypertensive patients","volume":"160","author":"Blacher","year":"2000","journal-title":"Arch Intern Med"}],"container-title":["European Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/eurheartj\/article-pdf\/39\/33\/3105\/25682588\/ehy287.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,17]],"date-time":"2019-10-17T06:54:59Z","timestamp":1571295299000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eurheartj\/article\/39\/33\/3105\/5033010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,4]]},"references-count":30,"journal-issue":{"issue":"33","published-online":{"date-parts":[[2018,6,4]]},"published-print":{"date-parts":[[2018,9,1]]}},"URL":"https:\/\/doi.org\/10.1093\/eurheartj\/ehy287","relation":{},"ISSN":["0195-668X","1522-9645"],"issn-type":[{"value":"0195-668X","type":"print"},{"value":"1522-9645","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,9,1]]},"published":{"date-parts":[[2018,6,4]]}}}