{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T17:54:55Z","timestamp":1790013295875,"version":"4.0.1"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2018,12,7]],"date-time":"2018-12-07T00:00:00Z","timestamp":1544140800000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["FS\/16\/72\/32270"],"award-info":[{"award-number":["FS\/16\/72\/32270"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Max\u2019s Foundation and Great Ormond Street Hospital Children\u2019s Charity"},{"name":"Great Ormond Street Hospital NHS Foundation Trust"},{"name":"UCL Great Ormond Street Institute of Child Health"},{"DOI":"10.13039\/100006662","name":"NIHR","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006662","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Great Ormond Street Hospital Biomedical Research Centre"},{"name":"NHS"},{"DOI":"10.13039\/100006662","name":"NIHR","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006662","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003921","name":"Department of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003921","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,3,21]]},"DOI":"10.1093\/eurheartj\/ehy798","type":"journal-article","created":{"date-parts":[[2018,11,7]],"date-time":"2018-11-07T15:10:55Z","timestamp":1541603455000},"page":"986-993","source":"Crossref","is-referenced-by-count":123,"title":["Clinical presentation and survival of childhood hypertrophic cardiomyopathy: a retrospective study in United Kingdom"],"prefix":"10.1093","volume":"40","author":[{"given":"Gabrielle","family":"Norrish","sequence":"first","affiliation":[{"name":"Centre for Inherited Cardiovascular Diseases, Great Ormond Street Hospital, Great Ormond Street, London, UK"},{"name":"Department of Paediatric Cardiology, Institute of Cardiovascular Sciences University College London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ella","family":"Field","sequence":"additional","affiliation":[{"name":"Centre for Inherited Cardiovascular Diseases, Great Ormond Street Hospital, Great Ormond Street, London, UK"},{"name":"Department of Paediatric Cardiology, Institute of Cardiovascular Sciences University College London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Mcleod","sequence":"additional","affiliation":[{"name":"Department of Paediatric Cardiology, Royal Hospital for Children, Glasgow, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Ilina","sequence":"additional","affiliation":[{"name":"Department of Paediatric Cardiology, Royal Hospital for Children, Glasgow, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham","family":"Stuart","sequence":"additional","affiliation":[{"name":"Department of Paediatric Cardiology, University Hospitals Bristol NHS Foundation Trust, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinay","family":"Bhole","sequence":"additional","affiliation":[{"name":"Department of Paediatric Cardiology, Birmingham Women and Children\u2019s NHS Foundation Trust, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orhan","family":"Uzun","sequence":"additional","affiliation":[{"name":"Department of Paediatric Cardiology, University Hospital of Wales, Cardiff, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elspeth","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Paediatric Cardiology, Leeds Teaching Hospital NHS Trust, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piers E F","family":"Daubeney","sequence":"additional","affiliation":[{"name":"Department of Paediatric Cardiology, Royal Brompton Hospital and National Heart and Lung Institute, Imperial College London Harefield, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amrit","family":"Lota","sequence":"additional","affiliation":[{"name":"Department of Paediatric Cardiology, Royal Brompton Hospital and National Heart and Lung Institute, Imperial College London Harefield, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie","family":"Linter","sequence":"additional","affiliation":[{"name":"Department of Paediatric Cardiology, University Hospitals of Leicester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujeev","family":"Mathur","sequence":"additional","affiliation":[{"name":"Department of Paediatric Cardiology, Evelina London Children\u2019s Hospital and Guys and St Thomas\u2019 NHS Foundation Trust, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara","family":"Bharucha","sequence":"additional","affiliation":[{"name":"Department of Paediatric Cardiology, University Hospital Southampton NHS Foundation Trust, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khoon Li","family":"Kok","sequence":"additional","affiliation":[{"name":"Department of Paediatric Cardiology, University Hospital Southampton NHS Foundation Trust, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satish","family":"Adwani","sequence":"additional","affiliation":[{"name":"Department of Paediatric Cardiology, Oxford University Hospitals NHS Foundation Trust, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline B","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Paediatric Cardiology, Alder Hey Children\u2019s Hospital, Liverpool, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zdenka","family":"Reinhardt","sequence":"additional","affiliation":[{"name":"Department of Paediatric Cardiology, The Freeman Hospital, Newcastle, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Pablo","family":"Kaski","sequence":"additional","affiliation":[{"name":"Centre for Inherited Cardiovascular Diseases, Great Ormond Street Hospital, Great Ormond Street, London, UK"},{"name":"Department of Paediatric Cardiology, Institute of Cardiovascular Sciences University College London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,12,6]]},"reference":[{"key":"key\n\t\t\t\t2019032104565008400_ehy798-B1","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1093\/oxfordjournals.aje.a009291","article-title":"Epidemiology of idiopathic cardiomyopathies in children and adolescents. A nationwide study in Finland","volume":"146","author":"Arola","year":"1997","journal-title":"Am J Epidemiol"},{"key":"key\n\t\t\t\t2019032104565008400_ehy798-B2","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1056\/NEJMoa021715","article-title":"The incidence of paediatric cardiomyopathy in two regions of the United States","volume":"348","author":"Lipshultz","year":"2003","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019032104565008400_ehy798-B3","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1056\/NEJMoa021737","article-title":"The epidemiology of childhood cardiomyopathy in Australia","volume":"348","author":"Nugent","year":"2003","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019032104565008400_ehy798-B4","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1161\/CIRCGENETICS.108.821314","article-title":"Prevalence of sarcomere protein gene mutations in preadolescent children with hypertrophic cardiomyopathy","volume":"2","author":"Kaski","year":"2009","journal-title":"Circ Cardiovasc Genet"},{"key":"key\n\t\t\t\t2019032104565008400_ehy798-B5","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1161\/CIRCULATIONAHA.106.621185","article-title":"Epidemiology and cause-specific outcome of hypertrophic cardiomyopathy in children: findings from the Paediatric Cardiomyopathy Registry","volume":"115","author":"Colan","year":"2007","journal-title":"Circulation"},{"key":"key\n\t\t\t\t2019032104565008400_ehy798-B6","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.ahj.2012.04.018","article-title":"Outcomes in children with Noonan syndrome and hypertrophic cardiomyopathy: a study from the Paediatric Cardiomyopathy Registry","volume":"164","author":"Wilkinson","year":"2012","journal-title":"Am Heart J"},{"key":"key\n\t\t\t\t2019032104565008400_ehy798-B7","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1016\/S0140-6736(13)61685-2","article-title":"Risk stratification at diagnosis for children with hypertrophic cardiomyopathy: an analysis of data from the Paediatric Cardiomyopathy Registry","volume":"382","author":"Lipshultz","year":"2013","journal-title":"Lancet"},{"key":"key\n\t\t\t\t2019032104565008400_ehy798-B8","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1161\/CIRCULATIONAHA.104.530303","article-title":"Clinical features and outcomes of childhood hypertrophic cardiomyopathy: results from a national population-based study","volume":"112","author":"Nugent","year":"2005","journal-title":"Circulation"},{"key":"key\n\t\t\t\t2019032104565008400_ehy798-B9","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCULATIONAHA.117.028895","article-title":"Long-term outcomes of hypertrophic cardiomyopathy diagnosed during childhood: results from a national population-based study","author":"Alexander","year":"2018","journal-title":"Circulation"},{"key":"key\n\t\t\t\t2019032104565008400_ehy798-B10","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1093\/eurheartj\/ehm342","article-title":"Classification of the cardiomyopathies: a position statement from the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases","volume":"29","author":"Elliott","year":"2007","journal-title":"Eur Heart J"},{"key":"key\n\t\t\t\t2019032104565008400_ehy798-B11","doi-asserted-by":"crossref","first-page":"2733","DOI":"10.1093\/eurheartj\/ehu284","article-title":"2014 ESC Guidelines on diagnosis and management of hypertrophic cardiomyopathy: the Task Force for the Diagnosis and Management of Hypertrophic Cardiomyopathy of the European Society of Cardiology (ESC)","volume":"35","author":"Elliott","year":"2014","journal-title":"Eur Heart J"},{"key":"key\n\t\t\t\t2019032104565008400_ehy798-B12","doi-asserted-by":"crossref","first-page":"2987","DOI":"10.1161\/01.CIR.96.9.2987","article-title":"Prospective prognostic assessment of blood pressure response during exercise in patients with hypertrophic cardiomyopathy","volume":"96","author":"Sadoul","year":"1997","journal-title":"Circulation"},{"key":"key\n\t\t\t\t2019032104565008400_ehy798-B13","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1111\/joic.12331","article-title":"Effectiveness of alcohol septal ablation versus transaortic extended myectomy in hypertrophic cardiomyopathy with midventricular obstruction","volume":"29","author":"Yang","year":"2016","journal-title":"J Interv Cardiol"},{"key":"key\n\t\t\t\t2019032104565008400_ehy798-B14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0033-0620(85)90024-6","article-title":"Hypertrophic cardiomyopathy. The importance of the site and the extent of hypertrophy. A review","volume":"28","author":"Wigle","year":"1985","journal-title":"Prog Cardiovasc Dis"},{"key":"key\n\t\t\t\t2019032104565008400_ehy798-B15","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1016\/S0735-1097(00)01003-2","article-title":"Sudden death in hypertrophic cardiomyopathy: identification of high risk patients","volume":"36","author":"Elliott","year":"2000","journal-title":"J Am Coll Cardiol"},{"key":"key\n\t\t\t\t2019032104565008400_ehy798-B16","first-page":"303","article-title":"A formula to estimate the approximate surface area if height and weight be known. 1916","volume":"5","author":"Du Bois","year":"1989","journal-title":"Nutrition"},{"key":"key\n\t\t\t\t2019032104565008400_ehy798-B17","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.117.006979","article-title":"Relationship of echocardiographic Z scores adjusted for body surface area to age, sex, race, and ethnicity: the paediatric heart network normal echocardiogram database","volume":"10","author":"Lopez","year":"2017","journal-title":"Circ Cardiovasc Imaging"},{"key":"key\n\t\t\t\t2019032104565008400_ehy798-B18","doi-asserted-by":"crossref","first-page":"e153","DOI":"10.1016\/j.jtcvs.2011.10.020","article-title":"2011 ACCF\/AHA guideline for the diagnosis and treatment of hypertrophic cardiomyopathy: a report of the American College of Cardiology Foundation\/American Heart Association Task Force on Practice Guidelines","volume":"142","author":"Gersh","year":"2011","journal-title":"J Thorac Cardiovasc Surg"},{"key":"key\n\t\t\t\t2019032104565008400_ehy798-B19","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1136\/hrt.2006.094730","article-title":"Outcomes after implantable cardioverter-defibrillator treatment in children with hypertrophic cardiomyopathy","volume":"93","author":"Kaski","year":"2007","journal-title":"Heart"},{"key":"key\n\t\t\t\t2019032104565008400_ehy798-B20","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1016\/j.jacc.2013.01.037","article-title":"Prevention of sudden cardiac death with implantable cardioverter-defibrillators in children and adolescents with hypertrophic cardiomyopathy","volume":"61","author":"Maron","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"key\n\t\t\t\t2019032104565008400_ehy798-B21","doi-asserted-by":"crossref","first-page":"2793","DOI":"10.1093\/eurheartj\/ehv316","article-title":"2015 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: the Task Force for the Management of Patients with Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death of the European Society of Cardiology (ESC). Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC)","volume":"36","author":"Priori","year":"2015","journal-title":"Eur Heart J"},{"key":"key\n\t\t\t\t2019032104565008400_ehy798-B22","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/0002-9149(81)90535-X","article-title":"Prognosis in hypertrophic cardiomyopathy: role of age and clinical, electrocardiographic and hemodynamic features","volume":"47","author":"McKenna","year":"1981","journal-title":"Am J Cardiol"},{"key":"key\n\t\t\t\t2019032104565008400_ehy798-B23","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1136\/adc.59.10.971","article-title":"Hypertrophic cardiomyopathy: an important cause of sudden death","volume":"59","author":"McKenna","year":"1984","journal-title":"Arch Dis Child"},{"key":"key\n\t\t\t\t2019032104565008400_ehy798-B24","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1093\/eurheartj\/ehn122","article-title":"Age- and gender-specific mortality rates in childhood hypertrophic cardiomyopathy","volume":"29","author":"Ostman-Smith","year":"2008","journal-title":"Eur Heart J"},{"key":"key\n\t\t\t\t2019032104565008400_ehy798-B25","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1136\/heartjnl-2012-303271","article-title":"A validation study of the 2003 American College of Cardiology\/European Society of Cardiology and 2011 American College of Cardiology Foundation\/American Heart Association risk stratification and treatment algorithms for sudden cardiac death in patients with hypertrophic cardiomyopathy","volume":"99","author":"O'Mahony","year":"2013","journal-title":"Heart"},{"key":"key\n\t\t\t\t2019032104565008400_ehy798-B26","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1161\/01.CIR.102.8.858","article-title":"Epidemiology of hypertrophic cardiomyopathy-related death: revisited in a large non-referral-based patient population","volume":"102","author":"Maron","year":"2000","journal-title":"Circulation"},{"key":"key\n\t\t\t\t2019032104565008400_ehy798-B27","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1001\/jama.2009.371","article-title":"Clinical outcome and phenotypic expression in LAMP2 cardiomyopathy","volume":"301","author":"Maron","year":"2009","journal-title":"JAMA"},{"key":"key\n\t\t\t\t2019032104565008400_ehy798-B28","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1001\/jamacardio.2018.0789","article-title":"Long-term outcomes of paediatric-onset hypertrophic cardiomyopathy and age-specific risk factors for lethal arrhythmic events","volume":"3","author":"Maurizi","year":"2018","journal-title":"JAMA Cardiol"}],"container-title":["European Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/eurheartj\/article-pdf\/40\/12\/986\/28170697\/ehy798.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,3,21]],"date-time":"2019-03-21T04:58:23Z","timestamp":1553144303000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eurheartj\/article\/40\/12\/986\/5232549"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,6]]},"references-count":28,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2018,12,6]]},"published-print":{"date-parts":[[2019,3,21]]}},"URL":"https:\/\/doi.org\/10.1093\/eurheartj\/ehy798","relation":{},"ISSN":["0195-668X","1522-9645"],"issn-type":[{"value":"0195-668X","type":"print"},{"value":"1522-9645","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,3,21]]},"published":{"date-parts":[[2018,12,6]]}}}