{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T04:26:55Z","timestamp":1772684815034,"version":"3.50.1"},"reference-count":66,"publisher":"Oxford University Press (OUP)","issue":"28","license":[{"start":{"date-parts":[[2019,4,8]],"date-time":"2019-04-08T00:00:00Z","timestamp":1554681600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,7,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p\/>\n               <jats:p>Transcatheter closure of patent foramen ovale (PFO) in patients with cryptogenic stroke is gaining momentum after the recent publication of four randomized clinical trials suggesting its benefit. This article provides a contemporary overview of the anatomy and pathophysiology of PFO, the available diagnostic tools for the assessment and risk stratification of PFO, and the current and future landscape of PFO closure devices and their optimal utilization. It also summarizes the current data on PFO closure for stroke prevention, and discusses the remaining open issues in the field of PFO closure.<\/jats:p>","DOI":"10.1093\/eurheartj\/ehz157","type":"journal-article","created":{"date-parts":[[2019,3,5]],"date-time":"2019-03-05T23:55:36Z","timestamp":1551830136000},"page":"2339-2350","source":"Crossref","is-referenced-by-count":34,"title":["Patent foramen ovale closure for secondary stroke prevention"],"prefix":"10.1093","volume":"40","author":[{"given":"Mohamad","family":"Alkhouli","sequence":"first","affiliation":[{"name":"Division of Cardiology, School of Medicine, West Virginia University, 1 Medical Center Drive, Morgantown, WV, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Horst","family":"Sievert","sequence":"additional","affiliation":[{"name":"Department of Medicine, CardioVascular Center Frankfurt, Seckbacher Landstra\u00dfe 65, Frankfurt am Main, Germany"},{"name":"Anglia Ruskin University, Cambridge Campus, East Rd, Cambridge, UK"},{"name":"Yunnan Hospital Fuwai, Intersection of Shahe Beilu and Jinchuan Lu, Kunming, China"},{"name":"University of California, 550 16th Street, San Francisco, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David R","family":"Holmes","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Mayo Clinic School of Medicine, 200 1st St SW, Rochester, MN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,4,8]]},"reference":[{"key":"2022102608154946800_ehz157-B1","first-page":"11","article-title":"Patent foramen ovale and paradoxical embolization: a historical perspective","volume":"66","author":"Lippmann","year":"1993","journal-title":"Yale J Biol Med"},{"key":"2022102608154946800_ehz157-B2","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1056\/NEJM198805053181802","article-title":"Prevalence of patent foramen ovale in patients with 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