{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:15:10Z","timestamp":1790813710936,"version":"4.1.0"},"reference-count":75,"publisher":"Oxford University Press (OUP)","issue":"13","license":[{"start":{"date-parts":[[2019,4,21]],"date-time":"2019-04-21T00:00:00Z","timestamp":1555804800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005615","name":"Beth Israel Deaconess Medical","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100005615","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Brigham Women\u2019s Hospital"},{"DOI":"10.13039\/100007478","name":"Cardiovascular Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sickle cell disease (SCD) is the most frequent genetic haemoglobinopathy worldwide. Early childhood mortality has dramatically decreased in high-income countries, and most patients now survive beyond the 5th decade. However, in the aging SCD population, the morbidity related to chronic organ damage, especially kidney and heart, has become a major concern. While pulmonary hypertension has attracted most attention, it appears that this condition is frequently linked to left heart failure (HF). Accordingly, SCD-associated cardiomyopathy is emerging as a major cause of reduced quality of life and early mortality in these patients. The diagnosis of this particular phenotype of high-output HF is challenging. Exercise intolerance and dyspnoea in SCD patients are linked to multiple causes including chronic anaemia. Moreover, echocardiographic features are unusual and can be misinterpreted. The classical diagnosis algorithm for HF is generally not suitable in SCD patients, and HF is poorly recognized and mostly diagnosed at a late congestive stage in routine practice. Such patients need to be identified at an earlier stage of myocardial dysfunction via improved phenotyping. This constitutes the first step towards further investigations in SCD needed to improve the prognosis and the quality of life. This article provides an updated review of the recent advances in the pathophysiology and diagnosis, and in addition, perspectives of new therapeutic approaches in SCD-related cardiac manifestations.<\/jats:p>","DOI":"10.1093\/eurheartj\/ehz217","type":"journal-article","created":{"date-parts":[[2019,3,27]],"date-time":"2019-03-27T21:34:13Z","timestamp":1553722453000},"page":"1365-1373","source":"Crossref","is-referenced-by-count":45,"title":["Cardiovascular manifestations of sickle cell disease"],"prefix":"10.1093","volume":"41","author":[{"given":"Nadjib","family":"Hammoudi","sequence":"first","affiliation":[{"name":"Sorbonne Universit\u00e9, Inserm, Institute of Cardiometabolism and Nutrition (ICAN), ACTION Study Group and Department of Cardiology , Institute of Cardiology (AP-HP), H\u00f4pital Piti\u00e9- Salp\u00eatri\u00e8re, Boulevard de l'h\u00f4pital, Paris F-75013, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Lionnet","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, Department of Internal Medicine, centre de r\u00e9f\u00e9rence de la dr\u00e9panocytose (AP-HP), Centre Hospitalier Universitaire Tenon , rue de la Chine, 75020 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alban","family":"Redheuil","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Imaging, Interventional and Thoracic Radiology (DICVRIT), H\u00f4pital Piti\u00e9- Salp\u00eatri\u00e8re, Boulevard de l'h\u00f4pital, Sorbonne Universit\u00e9, Inserm, CNRS 7371, Laboratoire d'Imagerie Biom\u00e9dicale, Institute of Cardiometabolism and Nutrition (ICAN), Institute of Cardiology (AP-HP), Paris F-75013, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Montalescot","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, Inserm, Institute of Cardiometabolism and Nutrition (ICAN), ACTION Study Group and Department of Cardiology , Institute of Cardiology (AP-HP), H\u00f4pital Piti\u00e9- Salp\u00eatri\u00e8re, Boulevard de l'h\u00f4pital, Paris F-75013, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,4,21]]},"reference":[{"key":"2022102608522000200_ehz217-B1","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/S0140-6736(12)61229-X","article-title":"Global epidemiology of sickle haemoglobin in neonates: a contemporary geostatistical model-based map and population 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