{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T07:42:25Z","timestamp":1793173345603,"version":"4.5.0"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2019,5,18]],"date-time":"2019-05-18T00:00:00Z","timestamp":1558137600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Netherlands Heart Foundation","award":["2016T026"],"award-info":[{"award-number":["2016T026"]}]},{"name":"Netherlands Heart Foundation","award":["HHSN268201500003I"],"award-info":[{"award-number":["HHSN268201500003I"]}]},{"name":"Netherlands Heart Foundation","award":["N01-HC-95159"],"award-info":[{"award-number":["N01-HC-95159"]}]},{"name":"Netherlands Heart Foundation","award":["N01-HC-95160"],"award-info":[{"award-number":["N01-HC-95160"]}]},{"name":"Netherlands Heart Foundation","award":["N01-HC-95161"],"award-info":[{"award-number":["N01-HC-95161"]}]},{"name":"Netherlands Heart Foundation","award":["N01-HC-95162"],"award-info":[{"award-number":["N01-HC-95162"]}]},{"name":"Netherlands Heart Foundation","award":["N01-HC-95163"],"award-info":[{"award-number":["N01-HC-95163"]}]},{"name":"Netherlands Heart Foundation","award":["N01-HC-95164"],"award-info":[{"award-number":["N01-HC-95164"]}]},{"name":"Netherlands Heart Foundation","award":["N01-HC-95165"],"award-info":[{"award-number":["N01-HC-95165"]}]},{"name":"Netherlands Heart Foundation","award":["N01-HC-95166"],"award-info":[{"award-number":["N01-HC-95166"]}]},{"name":"Netherlands Heart Foundation","award":["N01-HC-95167"],"award-info":[{"award-number":["N01-HC-95167"]}]},{"name":"Netherlands Heart Foundation","award":["N01-HC-95168"],"award-info":[{"award-number":["N01-HC-95168"]}]},{"name":"Netherlands Heart Foundation","award":["N01-HC-95169"],"award-info":[{"award-number":["N01-HC-95169"]}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["UL1-TR-000040"],"award-info":[{"award-number":["UL1-TR-000040"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["UL1-TR-001420"],"award-info":[{"award-number":["UL1-TR-001420"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"NCATS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HHSN268201700001I"],"award-info":[{"award-number":["HHSN268201700001I"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HHSN268201700002I"],"award-info":[{"award-number":["HHSN268201700002I"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HHSN268201700003I"],"award-info":[{"award-number":["HHSN268201700003I"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HHSN268201700005I"],"award-info":[{"award-number":["HHSN268201700005I"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HHSN268201700004I"],"award-info":[{"award-number":["HHSN268201700004I"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"\u2018Europe Against Cancer\u2019 programme of the European commission"},{"name":"Dutch ministry of health, Welfare and Sports"},{"name":"Netherlands Organization for Research and Development"},{"DOI":"10.13039\/501100000321","name":"World Cancer Research Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000321","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018867","name":"Heinz Nixdorf Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100018867","id-type":"DOI","asserted-by":"crossref"}]},{"name":"German Ministry of Education and Science"},{"DOI":"10.13039\/501100002347","name":"BMBF","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002946","name":"Deutsches Zentrum f\u00fcr Luft- und Raumfahrt","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002946","id-type":"DOI","asserted-by":"crossref"}]},{"name":"German Research Council Assessment","award":["SI 236\/8-1"],"award-info":[{"award-number":["SI 236\/8-1"]}]},{"name":"German Research Council Assessment","award":["SI 236\/9-1"],"award-info":[{"award-number":["SI 236\/9-1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,3,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>The benefit an individual can expect from preventive therapy varies based on risk-factor burden, competing risks, and treatment duration. We developed and validated the LIFEtime-perspective CardioVascular Disease (LIFE-CVD) model for the estimation of individual-level 10 years and lifetime treatment-effects of cholesterol lowering, blood pressure lowering, antithrombotic therapy, and smoking cessation in apparently healthy people.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Model development was conducted in the Multi-Ethnic Study of Atherosclerosis (n\u2009=\u20096715) using clinical predictors. The model consists of two complementary Fine and Gray competing-risk adjusted left-truncated subdistribution hazard functions: one for hard cardiovascular disease (CVD)-events, and one for non-CVD mortality. Therapy-effects were estimated by combining the functions with hazard ratios from preventive therapy trials. External validation was performed in the Atherosclerosis Risk in Communities (n\u2009=\u20099250), Heinz Nixdorf Recall (n\u2009=\u20094177), and the European Prospective Investigation into Cancer and Nutrition-Netherlands (n\u2009=\u200925\u00a0833), and Norfolk (n\u2009=\u200923\u00a0548) studies. Calibration of the LIFE-CVD model was good and c-statistics were 0.67\u20130.76. The output enables the comparison of short-term vs. long-term therapy-benefit. In two people aged 45 and 70 with otherwise identical risk-factors, the older patient has a greater 10-year absolute risk reduction (11.3% vs. 1.0%) but a smaller gain in life-years free of CVD (3.4 vs. 4.5\u2009years) from the same therapy. The model was developed into an interactive online calculator available via www.U-Prevent.com.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The model can accurately estimate individual-level prognosis and treatment-effects in terms of improved 10-year risk, lifetime risk, and life-expectancy free of CVD. The model is easily accessible and can be used to facilitate personalized-medicine and doctor\u2013patient communication.<\/jats:p>\n                  <jats:p\/>\n               <\/jats:sec>","DOI":"10.1093\/eurheartj\/ehz239","type":"journal-article","created":{"date-parts":[[2019,4,13]],"date-time":"2019-04-13T11:09:27Z","timestamp":1555153767000},"page":"1190-1199","source":"Crossref","is-referenced-by-count":111,"title":["Prediction of individualized lifetime benefit from cholesterol lowering, blood pressure lowering, antithrombotic therapy, and smoking cessation in apparently healthy people"],"prefix":"10.1093","volume":"41","author":[{"given":"Nicole E M","family":"Jaspers","sequence":"first","affiliation":[{"name":"Department of Vascular Medicine, University Medical Center Utrecht , Heidelberglaan 100, 3584 CX Utrecht, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J","family":"Blaha","sequence":"additional","affiliation":[{"name":"Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Johns Hopkins Hospital , 1800 Orleans St, Baltimore, MD 21287, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunihiro","family":"Matsushita","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health , 2024 E. Monument Street, Baltimore, MD 21287, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne T","family":"van der Schouw","sequence":"additional","affiliation":[{"name":"Julius Center for Health Sciences, University Medical Center Utrecht , Heidelberglaan 100, 3584 CX Utrecht, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1422-2993","authenticated-orcid":false,"given":"Nicholas J","family":"Wareham","sequence":"additional","affiliation":[{"name":"Medical Research Council Epidemiology Unit, University of Cambridge , Cambridge CB2 0QQ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kay-Tee","family":"Khaw","sequence":"additional","affiliation":[{"name":"Department of Public Health and Primary Care, University of Cambridge , 2 Worts' Causeway, Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie H","family":"Geisel","sequence":"additional","affiliation":[{"name":"Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, University Duisburg-Essen , Hufelandstra\u00dfe 55, 45122 Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils","family":"Lehmann","sequence":"additional","affiliation":[{"name":"Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, University Duisburg-Essen , Hufelandstra\u00dfe 55, 45122 Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raimund","family":"Erbel","sequence":"additional","affiliation":[{"name":"Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, University Duisburg-Essen , Hufelandstra\u00dfe 55, 45122 Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl-Heinz","family":"J\u00f6ckel","sequence":"additional","affiliation":[{"name":"Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, University Duisburg-Essen , Hufelandstra\u00dfe 55, 45122 Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolanda","family":"van der Graaf","sequence":"additional","affiliation":[{"name":"Julius Center for Health Sciences, University Medical Center Utrecht , Heidelberglaan 100, 3584 CX Utrecht, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W M Monique","family":"Verschuren","sequence":"additional","affiliation":[{"name":"Julius Center for Health Sciences, University Medical Center Utrecht , Heidelberglaan 100, 3584 CX Utrecht, Netherlands"},{"name":"National Institute for Public Health and the Environment (RIVM) , P O Box 1 3720 BA Bilthoven, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolanda M A","family":"Boer","sequence":"additional","affiliation":[{"name":"National Institute for Public Health and the Environment (RIVM) , P O Box 1 3720 BA Bilthoven, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay","family":"Nambi","sequence":"additional","affiliation":[{"name":"Center for Cardiovascular Disease Prevention, Michael E DeBakey Veterans Affairs Hospital , 6655 Tavis Street, Houston, TX 77030, USA"},{"name":"Department of Medicine, Baylor College of Medicine , 1 Baylor Plaza, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3951-5223","authenticated-orcid":false,"given":"Frank L J","family":"Visseren","sequence":"additional","affiliation":[{"name":"Department of Vascular Medicine, University Medical Center Utrecht , Heidelberglaan 100, 3584 CX Utrecht, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jannick A N","family":"Dorresteijn","sequence":"additional","affiliation":[{"name":"Department of Vascular Medicine, University Medical Center Utrecht , Heidelberglaan 100, 3584 CX Utrecht, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,5,18]]},"reference":[{"key":"2022102616514221800_ehz239-B1","first-page":"115.","article-title":"2016 ESC\/EAS guidelines for the management of dyslipidaemias","volume":"70","author":"Catapano","year":"2017","journal-title":"Rev Esp Cardiol (Engl Ed)"},{"key":"2022102616514221800_ehz239-B2","article-title":"2018 AHA\/ACC\/AACVPR\/AAPA\/ABC\/ACPM\/ADA\/AGS\/APhA\/ASPC\/NLA\/PCNA Guideline on the management of blood cholesterol: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines","author":"Grundy","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"2022102616514221800_ehz239-B3","first-page":"e484","article-title":"2017 ACC\/AHA\/AAPA\/ABC\/ACPM\/AGS\/APhA\/ASH\/ASPC\/NMA\/PCNA Guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines","volume":"138","author":"Whelton","year":"2018","journal-title":"Circulation"},{"key":"2022102616514221800_ehz239-B4","doi-asserted-by":"crossref","first-page":"3021","DOI":"10.1093\/eurheartj\/ehy339","article-title":"2018 ESC\/ESH Guidelines for the management of arterial hypertension","volume":"39","author":"Williams","year":"2018","journal-title":"Eur Heart J"},{"key":"2022102616514221800_ehz239-B5","doi-asserted-by":"crossref","first-page":"S49","DOI":"10.1161\/01.cir.0000437741.48606.98","article-title":"2013 ACC\/AHA guideline on the assessment of cardiovascular risk: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines","volume":"129","author":"Goff","year":"2014","journal-title":"Circulation"},{"key":"2022102616514221800_ehz239-B6","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1093\/eurheartj\/ehw106","article-title":"2016 European Guidelines on cardiovascular disease prevention in clinical practice: the Sixth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of 10 societies and by invited experts) Developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR)","volume":"37","author":"Piepoli","year":"2016","journal-title":"Eur Heart J"},{"key":"2022102616514221800_ehz239-B7","doi-asserted-by":"crossref","first-page":"ii1","DOI":"10.1136\/heartjnl-2014-305693","article-title":"Joint British Societies' consensus recommendations for the prevention of cardiovascular disease (JBS3)","volume":"100","author":"Board","year":"2014","journal-title":"Heart"},{"key":"2022102616514221800_ehz239-B8","doi-asserted-by":"crossref","first-page":"g4356.","DOI":"10.1136\/bmj.g4356","article-title":"Lipid modification and cardiovascular risk assessment for the primary and secondary prevention of cardiovascular disease: summary of updated NICE guidance","volume":"349","author":"Rabar","year":"2014","journal-title":"BMJ"},{"key":"2022102616514221800_ehz239-B9","volume-title":"Risk Estimation and the Prevention of Cardiovascular Disease. A National Clinical Guideline","year":"2007"},{"key":"2022102616514221800_ehz239-B10","doi-asserted-by":"crossref","first-page":"e1001361.","DOI":"10.1371\/journal.pmed.1001361","article-title":"Personalized prediction of lifetime benefits with statin therapy for asymptomatic individuals: a modeling study","volume":"9","author":"Ferket","year":"2012","journal-title":"PLoS Med"},{"key":"2022102616514221800_ehz239-B11","doi-asserted-by":"crossref","first-page":"389","DOI":"10.7326\/0003-4819-157-6-201209180-00002","article-title":"Development and validation of a coronary risk prediction model for older U.S. and European persons in the Cardiovascular Health Study and the Rotterdam Study","volume":"157","author":"Koller","year":"2012","journal-title":"Ann Intern Med"},{"key":"2022102616514221800_ehz239-B12","doi-asserted-by":"crossref","first-page":"c6624.","DOI":"10.1136\/bmj.c6624","article-title":"Derivation, validation, and evaluation of a new QRISK model to estimate lifetime risk of cardiovascular disease: cohort study using QResearch database","volume":"341","author":"Hippisley-Cox","year":"2010","journal-title":"BMJ"},{"key":"2022102616514221800_ehz239-B13","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1016\/j.jacc.2016.10.018","article-title":"Estimating longitudinal risks and benefits from cardiovascular preventive therapies among medicare patients: the million hearts longitudinal ASCVD risk assessment tool: a special report from the American Heart Association and American College of Cardiology","volume":"69","author":"Lloyd-Jones","year":"2017","journal-title":"J Am Coll Cardiol"},{"key":"2022102616514221800_ehz239-B14","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1093\/aje\/kwf113","article-title":"Multi-Ethnic Study of Atherosclerosis: objectives and design","volume":"156","author":"Bild","year":"2002","journal-title":"Am J Epidemiol"},{"key":"2022102616514221800_ehz239-B15","year":"1987"},{"key":"2022102616514221800_ehz239-B16","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1067\/mhj.2002.123579","article-title":"Assessment of clinically silent atherosclerotic disease and established and novel risk factors for predicting myocardial infarction and cardiac death in healthy middle-aged subjects: rationale and design of the Heinz Nixdorf RECALL Study. Risk Factors, Evaluation of Coronary Calcium and Lifestyle","volume":"144","author":"Schmermund","year":"2002","journal-title":"Am Heart J"},{"key":"2022102616514221800_ehz239-B17","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1093\/ije\/dyp217","article-title":"Cohort profile: the EPIC-NL study","volume":"39","author":"Beulens","year":"2010","journal-title":"Int J Epidemiol"},{"key":"2022102616514221800_ehz239-B18","first-page":"95","article-title":"EPIC-Norfolk: study design and characteristics of the cohort. European Prospective Investigation of Cancer","volume":"80","author":"Day","year":"1999","journal-title":"Br J Cancer"},{"key":"2022102616514221800_ehz239-B19","doi-asserted-by":"crossref","first-page":"i1548","DOI":"10.1136\/bmj.i1548","article-title":"How to translate clinical trial results into gain in healthy life expectancy for individual patients","volume":"352","author":"Dorresteijn","year":"2016","journal-title":"BMJ"},{"key":"2022102616514221800_ehz239-B20","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.1001\/archinte.162.22.2565","article-title":"Risk factors for coronary heart disease in African Americans: the atherosclerosis risk in communities study, 1987-1997","volume":"162","author":"Jones","year":"2002","journal-title":"Arch Intern Med"},{"key":"2022102616514221800_ehz239-B21","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1097\/00000441-198909000-00001","article-title":"Risk factors in early life as predictors of adult heart disease: the Bogalusa Heart Study","volume":"298","author":"Berenson","year":"1989","journal-title":"Am J Med Sci"},{"key":"2022102616514221800_ehz239-B22","doi-asserted-by":"crossref","first-page":"1519.","DOI":"10.1136\/bmj.38142.554479.AE","article-title":"Mortality in relation to smoking: 50 years' observations on male British doctors","volume":"328","author":"Doll","year":"2004","journal-title":"BMJ"},{"key":"2022102616514221800_ehz239-B23","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1016\/j.jacc.2015.01.043","article-title":"Clinician-patient risk discussion for atherosclerotic cardiovascular disease prevention: importance to implementation of the 2013 ACC\/AHA Guidelines","volume":"65","author":"Martin","year":"2015","journal-title":"J Am Coll Cardiol"},{"key":"2022102616514221800_ehz239-B24","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1093\/ajh\/5.3.111","article-title":"Diurnal blood pressure variation and cardiac mass in American blacks and whites and South African blacks","volume":"5","author":"Fumo","year":"1992","journal-title":"Am J Hypertens"},{"key":"2022102616514221800_ehz239-B25","first-page":"598","article-title":"Risk score overestimation: the impact of individual cardiovascular risk factors and preventive therapies on the performance of the American Heart Association-American College of Cardiology-Atherosclerotic Cardiovascular Disease risk score in a modern multi-ethnic cohort","volume":"38","author":"DeFilippis","year":"2017","journal-title":"Eur Heart J"},{"key":"2022102616514221800_ehz239-B26","doi-asserted-by":"crossref","first-page":"786","DOI":"10.7326\/M16-1739","article-title":"Calibration of the pooled cohort equations for atherosclerotic cardiovascular disease: an update","volume":"165","author":"Cook","year":"2016","journal-title":". Ann Intern Med"},{"key":"2022102616514221800_ehz239-B27","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1177\/0962280214567141","article-title":"Predictive accuracy of novel risk factors and markers: a simulation study of the sensitivity of different performance measures for the Cox proportional hazards regression model","volume":"26","author":"Austin","year":"2017","journal-title":"Stat Methods Med Res"}],"container-title":["European Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/eurheartj\/article-pdf\/41\/11\/1190\/46646926\/eurheartj_41_11_1190.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eurheartj\/article-pdf\/41\/11\/1190\/46646926\/eurheartj_41_11_1190.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T16:52:45Z","timestamp":1666803165000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eurheartj\/article\/41\/11\/1190\/5490733"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,18]]},"references-count":27,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2019,5,18]]},"published-print":{"date-parts":[[2020,3,14]]}},"URL":"https:\/\/doi.org\/10.1093\/eurheartj\/ehz239","relation":{},"ISSN":["0195-668X","1522-9645"],"issn-type":[{"value":"0195-668X","type":"print"},{"value":"1522-9645","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,3,14]]},"published":{"date-parts":[[2019,5,18]]}}}