{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T14:42:22Z","timestamp":1791988942344,"version":"4.4.0"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"35","license":[{"start":{"date-parts":[[2019,5,3]],"date-time":"2019-05-03T00:00:00Z","timestamp":1556841600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Medtronic Hellas S.A. Notably"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,9,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Sudden cardiac death (SCD) annual incidence is 0.6\u20131% in post-myocardial infarction (MI) patients with left ventricular ejection fraction (LVEF)\u226540%. No recommendations for implantable cardioverter-defibrillator (ICD) use exist in this population.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>We introduced a combined non-invasive\/invasive risk stratification approach in post-MI ischaemia-free patients, with LVEF\u2009\u2265\u200940%, in a multicentre, prospective, observational cohort study. Patients with at least one positive electrocardiographic non-invasive risk factor (NIRF): premature ventricular complexes, non-sustained ventricular tachycardia, late potentials, prolonged QTc, increased T-wave alternans, reduced heart rate variability, abnormal deceleration capacity with abnormal turbulence, were referred for programmed ventricular stimulation (PVS), with ICDs offered to those inducible. The primary endpoint was the occurrence of a major arrhythmic event (MAE), namely sustained ventricular tachycardia\/fibrillation, appropriate ICD activation or SCD. We screened and included 575 consecutive patients (mean age 57\u2009years, LVEF 50.8%). Of them, 204 (35.5%) had at least one positive NIRF. Forty-one of 152 patients undergoing PVS (27\u20137.1% of total sample) were inducible. Thirty-seven (90.2%) of them received an ICD. Mean follow-up was 32\u2009months and no SCDs were observed, while 9 ICDs (1.57% of total screened population) were appropriately activated. None patient without NIRFs or with NIRFs but negative PVS met the primary endpoint. The algorithm yielded the following: sensitivity 100%, specificity 93.8%, positive predictive value 22%, and negative predictive value 100%.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The two-step approach of the PRESERVE EF study detects a subpopulation of post-MI patients with preserved LVEF at risk for MAEs that can be effectively addressed with an ICD.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Clinicaltrials.gov identifier<\/jats:title>\n                  <jats:p>NCT02124018<\/jats:p>\n                  <jats:p\/>\n               <\/jats:sec>","DOI":"10.1093\/eurheartj\/ehz260","type":"journal-article","created":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T17:18:47Z","timestamp":1555003127000},"page":"2940-2949","source":"Crossref","is-referenced-by-count":139,"title":["Arrhythmic risk stratification in post-myocardial infarction patients with preserved ejection fraction: the PRESERVE EF study"],"prefix":"10.1093","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6628-0303","authenticated-orcid":false,"given":"Konstantinos A","family":"Gatzoulis","sequence":"first","affiliation":[{"name":"First Department of Cardiology, National and Kapodistrian University of Athens, Hippokrateion Hospital , 114 Vasilissis Sofias avenue, Athens, Attica, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Tsiachris","sequence":"additional","affiliation":[{"name":"First Department of Cardiology, National and Kapodistrian University of Athens, Hippokrateion Hospital , 114 Vasilissis Sofias avenue, Athens, Attica, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petros","family":"Arsenos","sequence":"additional","affiliation":[{"name":"First Department of Cardiology, National and Kapodistrian University of Athens, Hippokrateion Hospital , 114 Vasilissis Sofias avenue, Athens, Attica, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4861-2404","authenticated-orcid":false,"given":"Christos-Konstantinos","family":"Antoniou","sequence":"additional","affiliation":[{"name":"First Department of Cardiology, National and Kapodistrian University of Athens, Hippokrateion Hospital , 114 Vasilissis Sofias avenue, Athens, Attica, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0399-4111","authenticated-orcid":false,"given":"Polychronis","family":"Dilaveris","sequence":"additional","affiliation":[{"name":"First Department of Cardiology, National and Kapodistrian University of Athens, Hippokrateion Hospital , 114 Vasilissis Sofias avenue, Athens, Attica, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Skevos","family":"Sideris","sequence":"additional","affiliation":[{"name":"State Department of Cardiology, Hippokrateion Hospital , 114 Vasilissis Sofias avenue, Athens, Attica, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Kanoupakis","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital of Heraklion, University of Crete , Panepistimiou street, Heraklion, Crete, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanouil","family":"Simantirakis","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital of Heraklion, University of Crete , Panepistimiou street, Heraklion, Crete, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4228-3593","authenticated-orcid":false,"given":"Panagiotis","family":"Korantzopoulos","sequence":"additional","affiliation":[{"name":"First Cardiology Division, University Hospital of Ioannina, University of Ioannina , Stavros Niarchos avenue, Ioannina, Epirus, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Goudevenos","sequence":"additional","affiliation":[{"name":"First Cardiology Division, University Hospital of Ioannina, University of Ioannina , Stavros Niarchos avenue, Ioannina, Epirus, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiota","family":"Flevari","sequence":"additional","affiliation":[{"name":"Second Cardiology Department, National and Kapodistrian University of Athens, Attikon Hospital , 1 Rimini street, Chaidari, Attica, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efstathios","family":"Iliodromitis","sequence":"additional","affiliation":[{"name":"Second Cardiology Department, National and Kapodistrian University of Athens, Attikon Hospital , 1 Rimini street, Chaidari, Attica, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6364-0572","authenticated-orcid":false,"given":"Antonios","family":"Sideris","sequence":"additional","affiliation":[{"name":"Second State Cardiology Department, Evangelismos Hospital , 45-47 Ipsilantou street, Athens, Attica, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0885-9170","authenticated-orcid":false,"given":"Vassilios","family":"Vassilikos","sequence":"additional","affiliation":[{"name":"Third Cardiology Department, Aristotle University Medical School, Hippokrateion Hospital , 49 Konstantinoupoleos street, Thessaloniki, Macedonia, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7158-4950","authenticated-orcid":false,"given":"Nikolaos","family":"Fragakis","sequence":"additional","affiliation":[{"name":"Third Cardiology Department, Aristotle University Medical 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Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Tsimos","sequence":"additional","affiliation":[{"name":"First Cardiology Division, University Hospital of Ioannina, University of Ioannina , Stavros Niarchos avenue, Ioannina, Epirus, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5004-6635","authenticated-orcid":false,"given":"Iosif","family":"Xenogiannis","sequence":"additional","affiliation":[{"name":"Second Cardiology Department, National and Kapodistrian University of Athens, Attikon Hospital , 1 Rimini street, Chaidari, Attica, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3753-7883","authenticated-orcid":false,"given":"Konstantinos","family":"Vlachos","sequence":"additional","affiliation":[{"name":"Second State Cardiology Department, Evangelismos Hospital , 45-47 Ipsilantou street, Athens, Attica, 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