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S100A8\/A9 is a pro-inflammatory alarmin abundantly expressed in neutrophils that is rapidly released in the myocardium and circulation after myocardial ischaemia. We investigated the role of S100A8\/A9 in the innate immune response to MI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>In 524 patients with acute coronary syndrome (ACS), we found that high plasma S100A8\/A9 at the time of the acute event was associated with lower left ventricular ejection fraction (EF) at 1-year and increased hospitalization for heart failure (HF) during follow-up. In wild-type C57BL\/6 mice with MI induced by permanent coronary artery ligation, treatment with the S100A9 blocker ABR-238901 during the inflammatory phase of the immune response inhibited haematopoietic stem cell proliferation and myeloid cell egression from the bone marrow. The treatment reduced the numbers of neutrophils and monocytes\/macrophages in the myocardium, promoted an anti-inflammatory environment, and significantly improved cardiac function compared with MI controls. To mimic the clinical scenario, we further confirmed the effects of the treatment in a mouse model of ischaemia\/reperfusion. Compared with untreated mice, 3-day ABR-238901 treatment significantly improved left ventricular EF (48% vs. 35%, P\u2009=\u20090.002) and cardiac output (15.7 vs. 11.1\u2009mL\/min, P\u2009=\u20090.002) by Day 21 post-MI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Short-term S100A9 blockade inhibits inflammation and improves cardiac function in murine models of MI. As an excessive S100A8\/A9 release is linked to incident HF, S100A9 blockade might represent a feasible strategy to improve prognosis in ACS patients.<\/jats:p>\n                    <jats:p\/>\n                  <\/jats:sec>","DOI":"10.1093\/eurheartj\/ehz461","type":"journal-article","created":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T15:11:46Z","timestamp":1561993906000},"page":"2713-2723","source":"Crossref","is-referenced-by-count":153,"title":["Inhibition of pro-inflammatory myeloid cell responses by short-term S100A9 blockade improves cardiac function after myocardial infarction"],"prefix":"10.1093","volume":"40","author":[{"given":"Goran","family":"Marinkovi\u0107","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences Malm\u00f6, Lund University, CRC 91:12, Jan Waldenstr\u00f6ms gata 35, SE-214 28, Malm\u00f6, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1567-5102","authenticated-orcid":false,"given":"Helena","family":"Grauen Larsen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Skane University Hospital Malm\u00f6, Carl-Bertil Laurells gata 9, SE-214 28 Malm\u00f6, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8960-2125","authenticated-orcid":false,"given":"Troels","family":"Yndigegn","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Skane University Hospital Malm\u00f6, Carl-Bertil Laurells gata 9, SE-214 28 Malm\u00f6, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Istvan Adorjan","family":"Szabo","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, University of Medicine, Pharmacy, Sciences and Technology of Targu-Mures, Gheorghe Marinescu str. 38, 540139 Targu-Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Razvan Gheorghita","family":"Mares","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, University of Medicine, Pharmacy, Sciences and Technology of Targu-Mures, Gheorghe Marinescu str. 38, 540139 Targu-Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"de Camp","sequence":"additional","affiliation":[{"name":"DeVos Cardiovascular Research Program, Van Andel Institute, 333 Bostwick Ave NE, Grand Rapids, MI 49503, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0283-9542","authenticated-orcid":false,"given":"Matthew","family":"Weiland","sequence":"additional","affiliation":[{"name":"DeVos Cardiovascular Research Program, Van Andel Institute, 333 Bostwick Ave NE, Grand Rapids, MI 49503, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9371-8721","authenticated-orcid":false,"given":"Lukas","family":"Tomas","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Malm\u00f6, Lund University, CRC 91:12, Jan Waldenstr\u00f6ms gata 35, SE-214 28, Malm\u00f6, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2935-0181","authenticated-orcid":false,"given":"Isabel","family":"Goncalves","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Malm\u00f6, Lund University, CRC 91:12, Jan Waldenstr\u00f6ms gata 35, SE-214 28, Malm\u00f6, Sweden"},{"name":"Department of Cardiology, Skane University Hospital Malm\u00f6, Carl-Bertil Laurells gata 9, SE-214 28 Malm\u00f6, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Nilsson","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Malm\u00f6, Lund University, CRC 91:12, Jan Waldenstr\u00f6ms gata 35, SE-214 28, Malm\u00f6, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8446-0228","authenticated-orcid":false,"given":"Stefan","family":"Jovinge","sequence":"additional","affiliation":[{"name":"DeVos Cardiovascular Research Program, Van Andel Institute, 333 Bostwick Ave NE, Grand Rapids, MI 49503, USA"},{"name":"DeVos Cardiovascular Research Program, Fredrik Meijer Heart & Vascular Institute, Spectrum Health, 100 Michigan Street NE, Grand Rapids, MI 49503, USA"},{"name":"Cardiovascular Institute, Stanford Medical School, 265 Campus Drive, Stanford, CA 94305, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7587-5050","authenticated-orcid":false,"given":"Alexandru","family":"Schiopu","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Malm\u00f6, Lund University, CRC 91:12, 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