{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T03:05:20Z","timestamp":1768014320072,"version":"3.49.0"},"reference-count":96,"publisher":"Oxford University Press (OUP)","issue":"20","license":[{"start":{"date-parts":[[2019,9,11]],"date-time":"2019-09-11T00:00:00Z","timestamp":1568160000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"The Euro Heart Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,5,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Tricuspid regurgitation (TR) is a frequent and complex problem, commonly combined with left-sided heart disease, such as mitral regurgitation. Significant TR is associated with increased mortality if left untreated or recurrent after therapy. Tricuspid regurgitation was historically often disregarded and remained undertreated. Surgery is currently the only Class I Guideline recommended therapy for TR, in the form of annuloplasty, leaflet repair, or valve replacement. As growing experience of transcatheter therapy in structural heart disease, many dedicated transcatheter tricuspid repair or replacement devices, which mimic well-established surgical techniques, are currently under development. Nevertheless, many aspects of TR are little understood, including the disease process, surgical or interventional risk stratification, and predictors of successful therapy. The optimal treatment timing and the choice of proper surgical or interventional technique for significant TR remain to be elucidated. In this context, we aim to highlight the current evidence, underline major controversial issues in this field and present a future roadmap for TR therapy.<\/jats:p>\n               <jats:p\/>","DOI":"10.1093\/eurheartj\/ehz614","type":"journal-article","created":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T19:15:21Z","timestamp":1565378121000},"page":"1932-1940","source":"Crossref","is-referenced-by-count":45,"title":["Uncertainties and challenges in surgical and transcatheter tricuspid valve therapy: a state-of-the-art expert review"],"prefix":"10.1093","volume":"41","author":[{"given":"Chun Chin","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Cardiology, Thoraxcenter, Erasmus University Medical Center , Doctor Molewaterplein 40, 3015 GD Rotterdam, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin M","family":"Veen","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Thoraxcenter, Erasmus University Medical Center , Doctor Molewaterplein 40, 3015 GD Rotterdam, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1342-9191","authenticated-orcid":false,"given":"Rebecca T","family":"Hahn","sequence":"additional","affiliation":[{"name":"Structural Heart & Valve Center, New York Presbyterian Hospital, Columbia University Medical Center,161 Fort Washington Avenue , New York, NY 10032, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ad J J C","family":"Bogers","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Thoraxcenter, Erasmus University Medical Center , Doctor Molewaterplein 40, 3015 GD Rotterdam, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9035-343X","authenticated-orcid":false,"given":"Azeem","family":"Latib","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Montefiore Medical Center , 3400 Bainbridge Ave, The Bronx, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frans B S","family":"Oei","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Thoraxcenter, Erasmus University Medical Center , Doctor Molewaterplein 40, 3015 GD Rotterdam, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Abdelghani","sequence":"additional","affiliation":[{"name":"Heart Center, Segeberger Kliniken , Am Kurpark 1, 23795, Bad Segeberg, Germany"},{"name":"Department of Cardiology, Academic Medical Center, University of Amsterdam , Meibergdreef 9, 1105 AZ Amsterdam, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0047-7859","authenticated-orcid":false,"given":"Rodrigo","family":"Modolo","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Academic Medical Center, University of Amsterdam , Meibergdreef 9, 1105 AZ Amsterdam, the Netherlands"},{"name":"Cardiology Division, Department of Internal Medicine, University of Campinas (UNICAMP) , Campinas- SP, 13083-970, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siew Yen","family":"Ho","sequence":"additional","affiliation":[{"name":"Brompton Cardiac Morphology Unit, Royal Brompton Hospital, Imperial College London , London, SW7 2AZ UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Abdel-Wahab","sequence":"additional","affiliation":[{"name":"Cardiology Department, Heart Center Leipzig, University Hospital , Str\u00fcmpellstra\u00dfe 39, 04289 Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khalil","family":"Fattouch","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, GVM Care and Research, Maria Eleonora Hospital , Viale Regione Siciliana 1571, 90100 Palermo, Italy"},{"name":"GVM Care and Research, Maria Cecilia Hospital , Via Madonna di Genova, 1, 48033, Cotignola, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan","family":"Bosmans","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Antwerp , Wilrijkstraat 10, 2650 Edegem, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3293-9261","authenticated-orcid":false,"given":"Kadir","family":"Caliskan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Thoraxcenter, Erasmus University Medical Center , Doctor Molewaterplein 40, 3015 GD Rotterdam, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7295-1153","authenticated-orcid":false,"given":"Maurizio","family":"Taramasso","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, University Hospital of Z\u00fcrich, University of Z\u00fcrich , R\u00e4mistrasse 100, 8091 Z\u00fcrich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9636-1104","authenticated-orcid":false,"given":"Patrick W","family":"Serruys","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London , Guy Scadding Building, Dovehouse St, Chelsea, London SW3 6LY, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7368-0500","authenticated-orcid":false,"given":"Jeroen J","family":"Bax","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart Lung Center, Leiden University Medical Center , Albinusdreef 2, 2333 ZA Leiden, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas M D A","family":"van Mieghem","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Thoraxcenter, Erasmus University Medical Center , Doctor Molewaterplein 40, 3015 GD Rotterdam, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9809-5623","authenticated-orcid":false,"given":"Johanna J M","family":"Takkenberg","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Thoraxcenter, Erasmus University Medical Center , Doctor Molewaterplein 40, 3015 GD Rotterdam, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip","family":"Lurz","sequence":"additional","affiliation":[{"name":"Cardiology Department, Heart Center Leipzig, University Hospital , Str\u00fcmpellstra\u00dfe 39, 04289 Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Modine","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Hopital Cardiologique CHRU de Lille , 2 Avenue Oscar Lambret, 59000 Lille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0758-3539","authenticated-orcid":false,"given":"Osama","family":"Soliman","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Thoraxcenter, Erasmus University Medical Center , Doctor Molewaterplein 40, 3015 GD Rotterdam, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,9,11]]},"reference":[{"key":"2022102610240806300_ehz614-B1","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/S0002-9149(98)01064-9","article-title":"Prevalence and clinical determinants of mitral, tricuspid, and aortic regurgitation (the Framingham Heart Study)","volume":"83","author":"Singh","year":"1999","journal-title":"Am J Cardiol"},{"key":"2022102610240806300_ehz614-B2","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.jacc.2003.09.036","article-title":"Impact of tricuspid regurgitation on 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