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Clinical, biological, microbiological, and imaging [echocardiography, computed tomography (CT) scan, 18F-fluorodeoxyglucose positron emission tomography\/computed tomography (18F-FDG PET\/CT)] data were collected. Infective endocarditis was native (NVE) in 1764 (56.6%) patients, prosthetic (PVIE) in 939 (30.1%), and device-related (CDRIE) in 308 (9.9%). Infective endocarditis was community-acquired in 2046 (65.66%) patients. Microorganisms involved were staphylococci in 1085 (44.1%) patients, oral streptococci in 304 (12.3%), enterococci in 390 (15.8%), and Streptococcus gallolyticus in 162 (6.6%). 18F-fluorodeoxyglucose positron emission tomography\/computed tomography was performed in 518 (16.6%) patients and presented with cardiac uptake (major criterion) in 222 (42.9%) patients, with a better sensitivity in PVIE (66.8%) than in NVE (28.0%) and CDRIE (16.3%). Embolic events occurred in 20.6% of patients, and were significantly associated with tricuspid or pulmonary IE, presence of a vegetation and Staphylococcus aureus IE. According to ESC guidelines, cardiac surgery was indicated in 2160 (69.3%) patients, but finally performed in only 1596 (73.9%) of them. In-hospital death occurred in 532 (17.1%) patients and was more frequent in PVIE. Independent predictors of mortality were Charlson index, creatinine &gt; 2\u2009mg\/dL, congestive heart failure, vegetation length &gt; 10 mm, cerebral complications, abscess, and failure to undertake surgery when indicated.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Infective endocarditis is still a life-threatening disease with frequent lethal outcome despite profound changes in its clinical, microbiological, imaging, and therapeutic profiles.<\/jats:p>\n \n <\/jats:sec>","DOI":"10.1093\/eurheartj\/ehz620","type":"journal-article","created":{"date-parts":[[2019,8,12]],"date-time":"2019-08-12T15:14:33Z","timestamp":1565622873000},"page":"3222-3232","source":"Crossref","is-referenced-by-count":808,"title":["Clinical presentation, aetiology and outcome of infective endocarditis. 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