{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T11:04:00Z","timestamp":1784199840162,"version":"3.55.0"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"Supplement_C","license":[{"start":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T00:00:00Z","timestamp":1588118400000},"content-version":"vor","delay-in-days":28,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001003","name":"Boehringer Ingelheim","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001003","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Neoatherosclerosis is defined as foamy macrophage infiltration into the peri-strut or neointimal area after stent implantation, potentially leading to late stent failure through progressive atherosclerotic changes including calcification, fibroatheroma, thin-cap fibroatheroma, and rupture with stent thrombosis (ST) in advanced stages. Human autopsy as well as intravascular imaging studies have led to the understanding of neoatherosclerosis formation as a similar but significantly accelerated pathophysiology as compared to native atherosclerosis. This acceleration is mainly based on disrupted endothelial integrity with insufficient barrier function and augmented transmigration of lipids following vascular injury after coronary intervention and especially after implantation of drug-eluting stents. In this review, we summarize translational insights into disease pathophysiology and discuss therapeutic approaches to tackle this novel disease entity. We introduce a novel animal model of neoatherosclerosis alongside accompanying in vitro experiments, which show impaired endothelial integrity causing increased permeability for low-density lipoprotein cholesterol resulting in foam cell transformation of human monocytes. In addition, we discuss novel intravascular imaging surrogates to improve reliable diagnosis of early stage neoatherosclerosis. Finally, a therapeutic approach to prevent in-stent neoatherosclerosis with magnesium-based bioresorbable scaffolds and systemic statin treatment demonstrated the potential to improve arterial healing and re-endothelialization, leading to significantly mitigated neoatherosclerosis formation in an animal model of neoatherosclerosis.<\/jats:p>","DOI":"10.1093\/eurheartj\/suaa006","type":"journal-article","created":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T11:56:00Z","timestamp":1588161360000},"page":"C15-C25","source":"Crossref","is-referenced-by-count":3,"title":["Are we curing one evil with another? A translational approach targeting the role of neoatherosclerosis in late stent failure"],"prefix":"10.1093","volume":"22","author":[{"given":"Tobias","family":"Lenz","sequence":"first","affiliation":[{"name":"Deutsches Herzzentrum M\u00fcnchen (German Heart Centre Munich), Klinik f\u03b2 Herz- und Kreislauferkrankungen, Technische Universit\u00e4t M\u00fcnchen, Lazarettstra\u00dfe 36, 80363 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Nicol","sequence":"first","affiliation":[{"name":"Deutsches Herzzentrum M\u00fcnchen (German Heart Centre Munich), Klinik f\u03b2 Herz- und Kreislauferkrankungen, Technische Universit\u00e4t M\u00fcnchen, Lazarettstra\u00dfe 36, 80363 Munich, Germany"},{"name":"DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Biedersteiner Stra\u00dfe 29, 80802 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Isabel","family":"Castellanos","sequence":"first","affiliation":[{"name":"Deutsches Herzzentrum M\u00fcnchen (German Heart Centre Munich), Klinik f\u03b2 Herz- und Kreislauferkrankungen, Technische Universit\u00e4t M\u00fcnchen, Lazarettstra\u00dfe 36, 80363 Munich, Germany"},{"name":"DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Biedersteiner Stra\u00dfe 29, 80802 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayat Aboutaleb Abdellah","family":"Abdelgalil","sequence":"first","affiliation":[{"name":"Deutsches Herzzentrum M\u00fcnchen (German Heart Centre Munich), Klinik f\u03b2 Herz- und Kreislauferkrankungen, Technische Universit\u00e4t M\u00fcnchen, Lazarettstra\u00dfe 36, 80363 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Hoppmann","sequence":"first","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Innere Medizin I, Klinikum rechts der Isar, Technische Universit\u00e4t M\u00fcnchen, Ismaninger Str. 22, 81675 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Kempf","sequence":"first","affiliation":[{"name":"Deutsches Herzzentrum M\u00fcnchen (German Heart Centre Munich), Klinik f\u03b2 Herz- und Kreislauferkrankungen, Technische Universit\u00e4t M\u00fcnchen, Lazarettstra\u00dfe 36, 80363 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Koppara","sequence":"first","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Innere Medizin I, Klinikum rechts der Isar, Technische Universit\u00e4t M\u00fcnchen, Ismaninger Str. 22, 81675 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Lena","family":"Lahmann","sequence":"first","affiliation":[{"name":"Deutsches Herzzentrum M\u00fcnchen (German Heart Centre Munich), Klinik f\u03b2 Herz- und Kreislauferkrankungen, Technische Universit\u00e4t M\u00fcnchen, Lazarettstra\u00dfe 36, 80363 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alena","family":"R\u00fcscher","sequence":"first","affiliation":[{"name":"Deutsches Herzzentrum M\u00fcnchen (German Heart Centre Munich), Klinik f\u03b2 Herz- und Kreislauferkrankungen, Technische Universit\u00e4t M\u00fcnchen, Lazarettstra\u00dfe 36, 80363 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Horst","family":"Kessler","sequence":"first","affiliation":[{"name":"Department of Chemistry and Center for Integrated Protein Science, Institute for Advanced Study, Technische Universit\u00e4t M\u00fcnchen, Lichtenbergstr. 4, 85747 Garching, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Joner","sequence":"first","affiliation":[{"name":"Deutsches Herzzentrum M\u00fcnchen (German Heart Centre Munich), Klinik f\u03b2 Herz- und Kreislauferkrankungen, Technische Universit\u00e4t M\u00fcnchen, Lazarettstra\u00dfe 36, 80363 Munich, Germany"},{"name":"DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Biedersteiner Stra\u00dfe 29, 80802 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,4,29]]},"reference":[{"key":"2020042907555307000_suaa006-B1","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1136\/heartjnl-2013-304933","article-title":"Incidence and predictors of restenosis after coronary stenting in 10 004 patients with surveillance angiography","volume":"100","author":"Cassese","year":"2014","journal-title":"Heart"},{"key":"2020042907555307000_suaa006-B2","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1016\/j.jcin.2013.06.015","article-title":"Risk of stent thrombosis among bare-metal stents, first-generation drug-eluting stents, and second-generation drug-eluting stents: results from a registry of 18,334 patients","volume":"6","author":"Tada","year":"2013","journal-title":"JACC Cardiovasc Interv"},{"key":"2020042907555307000_suaa006-B3","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1161\/CIRCULATIONAHA.107.693739","article-title":"Pathological correlates of late drug-eluting stent thrombosis: strut coverage as a marker of endothelialization","volume":"115","author":"Finn","year":"2007","journal-title":"Circulation"},{"key":"2020042907555307000_suaa006-B4","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.jacc.2006.03.042","article-title":"Pathology of drug-eluting stents in humans. Delayed healing and late thrombotic risk","volume":"48","author":"Joner","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"2020042907555307000_suaa006-B5","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.jacc.2008.04.030","article-title":"Endothelial cell recovery between comparator polymer-based drug-eluting stents","volume":"52","author":"Joner","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"2020042907555307000_suaa006-B6","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.jcmg.2008.12.026","article-title":"Atherosclerotic and thrombogenic neointima formed over sirolimus drug-eluting stent. An angioscopic study","volume":"2","author":"Higo","year":"2009","journal-title":"JACC Cardiovasc Imaging"},{"key":"2020042907555307000_suaa006-B7","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.jcmg.2009.01.011","article-title":"One step forward and two steps back with drug-eluting-stents. From preventing restenosis to causing late thrombosis and nouveau atherosclerosis","volume":"2","author":"Nakazawa","year":"2009","journal-title":"JACC Cardiovasc Imaging"},{"key":"2020042907555307000_suaa006-B8","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1016\/j.jacc.2011.01.011","article-title":"The pathology of neoatherosclerosis in human coronary implants","volume":"57","author":"Nakazawa","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"2020042907555307000_suaa006-B9","doi-asserted-by":"crossref","first-page":"2608","DOI":"10.1093\/eurheartj\/ehv203","article-title":"Report of a European Society of Cardiology-European Association of Percutaneous Cardiovascular Interventions task force on the evaluation of coronary stents in Europe: executive summary","volume":"36","author":"Byrne","year":"2015","journal-title":"Eur Heart J"},{"key":"2020042907555307000_suaa006-B10","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1161\/CIRCULATIONAHA.113.001790","article-title":"Pathology of second-generation everolimus-eluting stents versus first-generation sirolimus- and paclitaxel-eluting stents in humans","volume":"129","author":"Otsuka","year":"2014","journal-title":"Circulation"},{"key":"2020042907555307000_suaa006-B11","doi-asserted-by":"crossref","first-page":"B190","DOI":"10.1016\/j.jacc.2014.07.724","article-title":"Contribution of in-stent neoatherosclerosis to late stent failure following bare metal and 1st- and 2nd-generation drug-eluting stent placement: an autopsy study","volume":"64","author":"Otsuka","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"2020042907555307000_suaa006-B12","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1093\/eurheartj\/ehv205","article-title":"Neoatherosclerosis: overview of histopathologic findings and implications for intravascular imaging assessment","volume":"36","author":"Otsuka","year":"2015","journal-title":"Eur Heart J"},{"key":"2020042907555307000_suaa006-B13","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1007\/s00392-019-01439-5","article-title":"Qualitative and quantitative neointimal characterization by optical coherence tomography in patients presenting with in-stent restenosis","volume":"108","author":"Xhepa","year":"2019","journal-title":"Clin Res Cardiol"},{"key":"2020042907555307000_suaa006-B14","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1161\/CIRCULATIONAHA.117.026788","article-title":"Optical coherence tomography findings in patients with coronary stent thrombosis: a report of the PRESTIGE consortium (Prevention of Late Stent Thrombosis by an Interdisciplinary Global European effort)","volume":"136","author":"Adriaenssens","year":"2017","journal-title":"Circulation"},{"key":"2020042907555307000_suaa006-B15","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1093\/eurheartj\/ehv711","article-title":"Mechanisms of stent thrombosis analysed by optical coherence tomography: insights from the national PESTO French registry","volume":"37","author":"Souteyrand","year":"2016","journal-title":"Eur Heart J"},{"key":"2020042907555307000_suaa006-B16","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1161\/CIRCULATIONAHA.115.019071","article-title":"Mechanisms of very late drug-eluting stent thrombosis assessed by optical coherence tomography","volume":"133","author":"Taniwaki","year":"2016","journal-title":"Circulation"},{"key":"2020042907555307000_suaa006-B17","first-page":"C7","article-title":"Pathophysiology of vascular healing and stent mediated arterial injury","volume":"4(Suppl C)","author":"Nakazawa","year":"2008","journal-title":"EuroIntervention"},{"key":"2020042907555307000_suaa006-B18","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1007\/s10439-009-9719-9","article-title":"Hemodynamically driven stent strut design","volume":"37","author":"Jim\u00e9nez","year":"2009","journal-title":"Ann Biomed Eng"},{"key":"2020042907555307000_suaa006-B19","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/ncpcardio1397","article-title":"Hemodynamic shear stress and the endothelium in cardiovascular pathophysiology","volume":"6","author":"Davies","year":"2009","journal-title":"Nat Clin Pract Cardiovasc Med"},{"key":"2020042907555307000_suaa006-B20","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.jacc.2010.05.066","article-title":"Coronary responses and differential mechanisms of late stent thrombosis attributed to first-generation sirolimus- and paclitaxel-eluting stents","volume":"57","author":"Nakazawa","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"2020042907555307000_suaa006-B21","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.117.007244","article-title":"Very late pathological responses to cobalt-chromium everolimus-eluting, stainless steel sirolimus-eluting, and cobalt-chromium bare metal stents in humans","volume":"6","author":"Mori","year":"2017","journal-title":"J Am Heart Assoc"},{"key":"2020042907555307000_suaa006-B22","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1002\/jbm.b.31988","article-title":"Polymer-free immobilization of a cyclic RGD peptide on a nitinol stent promotes integrin-dependent endothelial coverage of strut surfaces","volume":"100","author":"Joner","year":"2012","journal-title":"J Biomed Mater Res B Appl Biomater"},{"key":"2020042907555307000_suaa006-B23","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1016\/j.jcin.2018.02.029","article-title":"Neoatherosclerosis in patients with coronary stent thrombosis: findings from optical coherence tomography imaging (a report of the PRESTIGE Consortium)","volume":"11","author":"Joner","year":"2018","journal-title":"JACC Cardiovasc Interv"},{"key":"2020042907555307000_suaa006-B24","first-page":"292","article-title":"Neoatherosclerosis: from basic principles to intravascular imaging","volume":"66","author":"Nicol","year":"2018","journal-title":"Minerva Cardioangiol"},{"key":"2020042907555307000_suaa006-B25","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1161\/ATVBAHA.113.301227","article-title":"Tissue characterization after drug-eluting stent implantation using optical coherence tomography","volume":"33","author":"Malle","year":"2013","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2020042907555307000_suaa006-B26","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1093\/ehjci\/jeu307","article-title":"Identification and quantification ofmacrophage presence in coronary atherosclerotic plaques by optical coherence tomography","volume":"16","author":"Di Vito","year":"2015","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"2020042907555307000_suaa006-B27","doi-asserted-by":"crossref","first-page":"011105","DOI":"10.1117\/1.3280271","article-title":"Atherosclerotic tissue characterization in vivo by optical coherence tomography attenuation imaging","volume":"15","author":"van Soest","year":"2010","journal-title":"J Biomed Opt"},{"key":"2020042907555307000_suaa006-B28","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1161\/CIRCRESAHA.117.310275","article-title":"Bioresorbable scaffold the emerging reality and future directions","volume":"120","author":"Sotomi","year":"2017","journal-title":"Circ Res"},{"key":"2020042907555307000_suaa006-B29","first-page":"1","article-title":"Everolimus-eluting bioresorbable vascular scaff olds versus everolimus-eluting metallic stents: a meta-analysis of","volume":"6736","author":"Cassese","year":"2015","journal-title":"Lancet"},{"key":"2020042907555307000_suaa006-B30","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/S0140-6736(17)31470-8","article-title":"2-year outcomes with the Absorb bioresorbable scaffold for treatment of coronary artery disease: a systematic review and meta-analysis of seven randomised trials with an individual patient data substudy","volume":"390","author":"Ali","year":"2017","journal-title":"Lancet"},{"key":"2020042907555307000_suaa006-B31","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1161\/CIRCULATIONAHA.117.031843","article-title":"Three-year outcomes with the absorb bioresorbable scaffold","volume":"137","author":"Ali","year":"2018","journal-title":"Circulation"},{"key":"2020042907555307000_suaa006-B32","first-page":"517","article-title":"2018 ESC\/EACTS Guidelines on myocardial revascularization","volume":"46","author":"Neumann","year":"2018","journal-title":"Eur Heart J"},{"key":"2020042907555307000_suaa006-B33","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.jacc.2015.12.019","article-title":"Bioresorbable coronary scaffold thrombosis: multicenter comprehensive analysis of clinical presentation, mechanisms, and predictors","volume":"67","author":"Puricel","year":"2016","journal-title":"J Am Coll Cardiol"},{"key":"2020042907555307000_suaa006-B34","doi-asserted-by":"crossref","first-page":"2330","DOI":"10.1016\/j.jacc.2017.09.014","article-title":"Mechanisms of very late bioresorbable scaffold thrombosis: the INVEST registry","volume":"70","author":"Yamaji","year":"2017","journal-title":"J Am Coll Cardiol"},{"key":"2020042907555307000_suaa006-B35","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCINTERVENTIONS.117.005663","article-title":"Rather thick, yet antithrombogenic: is the Magmaris scaffold a new hope for bioresorbable coronary scaffold?","volume":"10","author":"Onuma","year":"2017","journal-title":"Circ Cardiovasc Interv"},{"key":"2020042907555307000_suaa006-B36","doi-asserted-by":"crossref","first-page":"440","DOI":"10.4244\/EIJ-D-16-00915","article-title":"Second-generation magnesium scaffold Magmaris: device design and preclinical evaluation in a porcine coronary artery model","volume":"13","author":"Waksman","year":"2017","journal-title":"EuroIntervention"},{"key":"2020042907555307000_suaa006-B37","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1016\/j.jcin.2017.09.041","article-title":"The state of the absorb bioresorbable scaffold: consensus from an expert panel","volume":"10","author":"Bangalore","year":"2017","journal-title":"JACC Cardiovasc Interv"},{"key":"2020042907555307000_suaa006-B38","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.4244\/EIJ-D-17-00958","article-title":"Comparison of acute thrombogenicity for magnesium versus stainless steel stents in a porcine arteriovenous shunt model","volume":"14","author":"Lipinski","year":"2019","journal-title":"EuroIntervention"},{"key":"2020042907555307000_suaa006-B39","doi-asserted-by":"crossref","first-page":"e1040","DOI":"10.4244\/EIJ-D-17-00708","article-title":"Preclinical evaluation of degradation kinetics and elemental mapping of first- and second-generation bioresorbable magnesium scaffolds","volume":"14","author":"Joner","year":"2018","journal-title":"EuroIntervention"},{"key":"2020042907555307000_suaa006-B40","doi-asserted-by":"crossref","first-page":"e004762","DOI":"10.1161\/CIRCINTERVENTIONS.116.004762","article-title":"Comparison of acute thrombogenicity for metallic and polymeric bioabsorbable scaffolds: magmaris versus absorb in a porcine arteriovenous shunt model","volume":"10","author":"Waksman","year":"2017","journal-title":"Circ Cardiovasc Interv"},{"key":"2020042907555307000_suaa006-B41","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1161\/CIRCINTERVENTIONS.113.000990","article-title":"Long-term safety of an everolimus-eluting bioresorbable vascular scaffold and the cobalt-chromium XIENCE v stent in a porcine coronary artery model","volume":"7","author":"Otsuka","year":"2014","journal-title":"Circ Cardiovasc Interv"},{"key":"2020042907555307000_suaa006-B42","article-title":"Safety and performance of a resorbable magnesium scaffold under real-world conditions: 12-month outcomes of the first 400 patients enrolled in the BIOSOLVE-IV registry","author":"Verheye","year":"2019","journal-title":"EuroIntervention"},{"key":"2020042907555307000_suaa006-B43","article-title":"Sustained safety and performance of the second-generation drug-eluting absorbable metal scaffold (DREAMS 2G) in patients with de novo coronary lesions: 3-year clinical results and angiographic findings of the BIOSOLVE-II first-in-man trial","author":"Haude","year":"2019","journal-title":"EuroIntervention"},{"key":"2020042907555307000_suaa006-B44","doi-asserted-by":"crossref","first-page":"E502","DOI":"10.1002\/ccd.27680","article-title":"Safety and clinical performance of a drug eluting absorbable metal scaffold in the treatment of subjects with de novo lesions in native coronary arteries: pooled 12-month outcomes of BIOSOLVE-II and BIOSOLVE-III","volume":"92","author":"Haude","year":"2018","journal-title":"Catheter Cardiovasc Interv"},{"key":"2020042907555307000_suaa006-B45","doi-asserted-by":"crossref","first-page":"432","DOI":"10.4244\/EIJ-D-17-00254","article-title":"Sustained safety and clinical performance of a drug-eluting absorbable metal scaffold up to 24 months: pooled outcomes of BIOSOLVE-II and BIOSOLVE-III","volume":"13","author":"Haude","year":"2017","journal-title":"EuroIntervention"},{"key":"2020042907555307000_suaa006-B46","doi-asserted-by":"crossref","first-page":"3287","DOI":"10.1016\/j.jacc.2018.09.019","article-title":"Ultrathin bioresorbable polymer sirolimus-eluting stents versus thin durable polymer everolimus-eluting stents","volume":"72","author":"Kandzari","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"2020042907555307000_suaa006-B47","first-page":"15","article-title":"The COMBO stent: can it deliver on its dual promise?","volume":"3","author":"Colleran","year":"2017","journal-title":"AsiaIntervention"},{"key":"2020042907555307000_suaa006-B48","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1093\/eurheartj\/ehw097","article-title":"Hybrid intravascular imaging: recent advances, technical considerations, and current applications in the study of plaque pathophysiology","volume":"38","author":"Bourantas","year":"2017","journal-title":"Eur Heart J"},{"key":"2020042907555307000_suaa006-B49","first-page":"456","article-title":"Molecular multimodality imaging: has a long-standing dream come true?","volume":"38","author":"Joner","year":"2017","journal-title":"Eur Heart J"},{"key":"2020042907555307000_suaa006-B50","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1161\/CIRCRESAHA.115.306247","article-title":"Imaging atherosclerosis","volume":"118","author":"Tarkin","year":"2016","journal-title":"Circ Res"}],"container-title":["European Heart Journal Supplements"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/eurheartjsupp\/article-pdf\/22\/Supplement_C\/C15\/33144393\/suaa006.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/eurheartjsupp\/article-pdf\/22\/Supplement_C\/C15\/33144393\/suaa006.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T11:56:37Z","timestamp":1588161397000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eurheartjsupp\/article\/22\/Supplement_C\/C15\/5826771"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,1]]},"references-count":50,"journal-issue":{"issue":"Supplement_C","published-online":{"date-parts":[[2020,4,29]]},"published-print":{"date-parts":[[2020,4,1]]}},"URL":"https:\/\/doi.org\/10.1093\/eurheartj\/suaa006","relation":{},"ISSN":["1520-765X","1554-2815"],"issn-type":[{"value":"1520-765X","type":"print"},{"value":"1554-2815","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,4]]},"published":{"date-parts":[[2020,4,1]]}}}