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The causal relationship between atrial fibrillation (AF) and ischaemic stroke has been challenged by the recent uncovering of the lack of temporal association between thrombo-embolic cerebral events and paroxysmal AF or tachycardia. General conditions, such as the one considered in the definition of the CHA2DS2-VASc score, or specific atrial pathology (also independently occurring), could predispose to cerebral embolism.<\/jats:p>","DOI":"10.1093\/eurheartj\/suaa054","type":"journal-article","created":{"date-parts":[[2020,6,4]],"date-time":"2020-06-04T09:12:44Z","timestamp":1591261964000},"page":"E30-E33","source":"Crossref","is-referenced-by-count":5,"title":["Beyond CHA2DS2-VASc in atrial fibrillation: the atrium and the risk of stroke"],"prefix":"10.1093","volume":"22","author":[{"given":"Alessandro","family":"Boccanelli","sequence":"first","affiliation":[{"name":"Casa di Cura Quisisana, Via Gian Giacomo Porro 5, 00153 Roma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,3,23]]},"reference":[{"key":"2020060405102549100_suaa054-B1","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1093\/europace\/euw295","article-title":"2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS","volume":"18","author":"Kirchhof","year":"2016","journal-title":"Europace"},{"key":"2020060405102549100_suaa054-B2","first-page":"166","article-title":"Anticoagulation in elderly patients at high risk of atrial fibrillation without documented arrhythmias","volume":"14","author":"Mart\u00ednez-Sell\u00e9s","year":"2017","journal-title":"J Geriatr Cardiol"},{"key":"2020060405102549100_suaa054-B3","doi-asserted-by":"crossref","first-page":"176","DOI":"10.5551\/jat.34900","article-title":"CHADS2 and CHA2DS2-VASc scores predict the risk of ischemic stroke outcome in patients with interatrial block without atrial fibrillation","volume":"24","author":"Wu","year":"2017","journal-title":"J Atheroscler Thromb"},{"key":"2020060405102549100_suaa054-B4","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.recesp.2016.01.009","article-title":"Should we anticoagulate patients at high risk of atrial fibrillation?","volume":"69","author":"Mart\u00ednez-Sell\u00e9s","year":"2016","journal-title":"Rev Esp Cardiol"},{"key":"2020060405102549100_suaa054-B5","doi-asserted-by":"crossref","first-page":"e12417.","DOI":"10.1111\/anec.12417","article-title":"Anticoagulation in patients at high risk of stroke without documented atrial fibrillation. 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