{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T15:12:11Z","timestamp":1791817931385,"version":"4.3.4"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"Supplement_E","license":[{"start":{"date-parts":[[2020,6,4]],"date-time":"2020-06-04T00:00:00Z","timestamp":1591228800000},"content-version":"vor","delay-in-days":72,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Atherosclerosis is a condition characterized by a long, initial, asymptomatic phase. Progression of disease could lead to acute coronary events, such as acute myocardial infarction, unstable angina, or sudden cardiac death. However, there are imaging techniques, namely vascular echography and assessment of coronary calcium, capable to make the diagnosis of atherosclerosis at an early stage. There are several studies demonstrating the ability of statins to delay, and in some situation even revert the progression of this condition. Subclinical atherosclerosis is highly prevalent in people with optimal control of the risk factors, and the imaging techniques have been shown to provide an added value over the traditional risk factors: by identifying directly the condition, these techniques allow the reclassification of low-risk to intermediate- or high-risk subjects, thus directing the primary prevention therapeutic strategies, based on high efficacy statins, aimed at delaying or reversing the progression of the disease.<\/jats:p>","DOI":"10.1093\/eurheartj\/suaa068","type":"journal-article","created":{"date-parts":[[2020,6,4]],"date-time":"2020-06-04T05:12:54Z","timestamp":1591247574000},"page":"E87-E90","source":"Crossref","is-referenced-by-count":52,"title":["Subclinical atherosclerosis: how and when to treat it?"],"prefix":"10.1093","volume":"22","author":[{"given":"Laura","family":"Gatto","sequence":"first","affiliation":[{"name":"Cardiologia d\u2019Urgenza, Azienda Ospedaliera San Giovanni Addolorata, Roma, Italy"},{"name":"Centro per la Lotta Contro l\u2019Infarto, Fondazione ONLUS, Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Prati","sequence":"first","affiliation":[{"name":"Centro per la Lotta Contro l\u2019Infarto, Fondazione ONLUS, Roma, Italy"},{"name":"UniCamillus - Saint Camillus International University of Health Sciences, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,3,24]]},"reference":[{"key":"2020060405103109900_suaa068-B1","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1111\/j.1742-1241.2008.01804.x","article-title":"Subclinical atherosclerosis: what it is, what it means and what we can do about it","volume":"62","author":"Toth","year":"2008","journal-title":"Int J Clin Pract"},{"key":"2020060405103109900_suaa068-B2","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1093\/oxfordjournals.aje.a116963","article-title":"Prevalence of subclinical atherosclerosis and cardiovascular disease and association with risk factors in the Cardiovascular Health Study","volume":"139","author":"Kuller","year":"1994","journal-title":"Am J Epidemiol"},{"key":"2020060405103109900_suaa068-B3","doi-asserted-by":"crossref","first-page":"47","DOI":"10.2174\/1573403X12666160803095855","article-title":"Imaging subclinical atherosclerosis: where do we stand?","volume":"13","author":"Papageorgiou","year":"2016","journal-title":"Curr Cardiol Rev"},{"key":"2020060405103109900_suaa068-B4","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1001\/jama.2012.9630","article-title":"Common carotid intima-media thickness measurements in cardiovascular risk prediction: a meta-analysis","volume":"308","author":"Den Ruijter","year":"2012","journal-title":"JAMA"},{"key":"2020060405103109900_suaa068-B5","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1016\/j.jacc.2009.11.075","article-title":"Carotid intima-media thickness and presence or absence of plaque improves prediction of coronary heart disease risk: the ARIC (Atherosclerosis Risk In Communities) study","volume":"55","author":"Nambi","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"2020060405103109900_suaa068-B6","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/S0735-1097(00)01119-0","article-title":"Correlation of coronary calcification and angiographically documented stenoses in patients with suspected coronary artery disease: results of 1,764 patients","volume":"37","author":"Haberl","year":"2001","journal-title":"J Am Coll Cardiol"},{"key":"2020060405103109900_suaa068-B7","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1016\/j.jacc.2010.11.053","article-title":"Distribution of coronary artery calcium scores by Framingham 10-year risk strata in the MESA (Multi-Ethnic Study of Atherosclerosis) potential implications for coronary risk assessment","volume":"57","author":"Okwuosa","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"2020060405103109900_suaa068-B8","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1161\/CIRCULATIONAHA.114.014310","article-title":"Prevalence, vascular distribution, and multiterritorial extent of subclinical atherosclerosis in a middle-aged cohort: the PESA (Progression of Early Subclinical Atherosclerosis) Study","volume":"131","author":"Fern\u00e1ndez-Friera","year":"2015","journal-title":"Circulation"},{"key":"2020060405103109900_suaa068-B9","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/S0140-6736(00)04053-8","article-title":"Effect of aggressive versus conventional lipid lowering on atherosclerosis progression in familial hypercholesterolaemia (ASAP): a prospective, randomised, double-blind trial","volume":"357","author":"Smilde","year":"2001","journal-title":"Lancet"},{"key":"2020060405103109900_suaa068-B10","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1001\/jama.297.12.1344","article-title":"METEOR Study Group. 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