{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T18:59:46Z","timestamp":1768071586762,"version":"3.49.0"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"Supplement_F","license":[{"start":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T00:00:00Z","timestamp":1594771200000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"European Commission: Operational Programme: Research, Development, and Education"},{"name":"INTERCARDIS","award":["CZ.02.1.01\/0.0\/0.0\/16_026\/0008388"],"award-info":[{"award-number":["CZ.02.1.01\/0.0\/0.0\/16_026\/0008388"]}]},{"name":"Charles University Research Centre Program","award":["UNCE\/MED\/002"],"award-info":[{"award-number":["UNCE\/MED\/002"]}]},{"name":"Cardiovascular Research Program of the Charles University"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We aimed to determine the incidence, severity, and long-term impact of intravascular haemolysis after self-expanding transcatheter aortic valve implantation (TAVI). We believe this should be evaluated before extending the indications of TAVI to younger low-risk patients. Prospective, academic, single centre study of 94 consecutive patients treated with supra-annular self-expandable TAVI prosthesis between April 2009 and January 2014. Haemolysis at 1-year post-TAVI was defined per the published criteria based on levels of haemoglobin, reticulocyte and schistocyte count, lactate dehydrogenase (LDH), and haptoglobin. All patients had long-term clinical follow-up (6\u2009years). The incidence of haemolysis at 1-year follow-up varied between 9% and 28%, based on different haemolysis definitions. Haemolysis was mild in all cases, no patient had markedly increased LDH levels. The presence of moderate\/severe paravalvular aortic regurgitation was associated with haemolysis (7.7% vs. 23.1%, P\u2009=\u20090.044) and aortic valve area post-TAVI did not differ between groups with or without haemolysis (1.01 vs. 0.92 cm2\/m2, P\u2009=\u20090.23) (definition including schistocyte count). The presence of haemolysis did not have any impact on patient prognosis after 6\u2009years with log-rank test P\u2009=\u20090.80. Intravascular haemolysis after TAVI with self-expandable prosthesis is present in 9\u201328% of patients depending on the definition of haemolysis. The presence of haemolysis is associated with moderate\/severe paravalvular aortic regurgitation but not with post-TAVI aortic valve area. Haemolysis is mild with no impact on prognosis.<\/jats:p>","DOI":"10.1093\/eurheartj\/suaa098","type":"journal-article","created":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T09:02:57Z","timestamp":1594803777000},"page":"F44-F50","source":"Crossref","is-referenced-by-count":9,"title":["Intravascular haemolysis after transcatheter aortic valve implantation with self-expandable prosthesis: incidence, severity, and impact on long-term mortality"],"prefix":"10.1093","volume":"22","author":[{"given":"Andrea","family":"\u0160ir\u00e1kov\u00e1","sequence":"first","affiliation":[{"name":"Cardiocenter, University Hospital Kr\u00e1lovsk\u00e9 Vinohrady and 3rd Faculty of Medicine, Charles University, Rusk\u00e1 87, Prague 10 100 00, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petr","family":"Tou\u0161ek","sequence":"first","affiliation":[{"name":"Cardiocenter, University Hospital Kr\u00e1lovsk\u00e9 Vinohrady and 3rd Faculty of Medicine, Charles University, Rusk\u00e1 87, Prague 10 100 00, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franti\u0161ek","family":"Bedn\u00e1\u0159","sequence":"first","affiliation":[{"name":"Cardiocenter, University Hospital Kr\u00e1lovsk\u00e9 Vinohrady and 3rd Faculty of Medicine, Charles University, Rusk\u00e1 87, Prague 10 100 00, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hana","family":"L\u00ednkov\u00e1","sequence":"first","affiliation":[{"name":"Cardiocenter, University Hospital Kr\u00e1lovsk\u00e9 Vinohrady and 3rd Faculty of Medicine, Charles University, Rusk\u00e1 87, Prague 10 100 00, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marek","family":"Labo\u0161","sequence":"first","affiliation":[{"name":"Cardiocenter, University Hospital Kr\u00e1lovsk\u00e9 Vinohrady and 3rd Faculty of Medicine, Charles University, Rusk\u00e1 87, Prague 10 100 00, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jakub","family":"Sul\u017eenko","sequence":"first","affiliation":[{"name":"Cardiocenter, University Hospital Kr\u00e1lovsk\u00e9 Vinohrady and 3rd Faculty of Medicine, Charles University, Rusk\u00e1 87, Prague 10 100 00, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Havl\u00edkov\u00e1","sequence":"first","affiliation":[{"name":"Cardiocenter, University Hospital Kr\u00e1lovsk\u00e9 Vinohrady and 3rd Faculty of Medicine, Charles University, Rusk\u00e1 87, Prague 10 100 00, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marek","family":"Neuberg","sequence":"first","affiliation":[{"name":"Medtronic Czechia, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viktor","family":"Ko\u010dka","sequence":"first","affiliation":[{"name":"Cardiocenter, University Hospital Kr\u00e1lovsk\u00e9 Vinohrady and 3rd 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