{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T20:31:25Z","timestamp":1784233885937,"version":"3.55.0"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"Supplement_L","license":[{"start":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T00:00:00Z","timestamp":1605657600000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>During the last decade, transcatheter aortic valve implantation (TAVI) has represented a valid alternative to surgical aortic valve replacement in patients with aortic stenosis and elevated surgical risk. Recent randomized clinical trials reported excellent results also for patients at low surgical risk, but in clinical practice, the mean age of the patients treated remain over 75\u2009years, and the presence of a bicuspid aortic valve still represents an important exclusion criteria. Today, aortic valve replacement with a mechanical prosthesis remains the treatment of choice for young adults with aortic stenosis, although the desire to avoid oral anticoagulants drives more patients younger than 65\u2009years of age towards biological prostheses. Furthermore, despite the follow-up of patients after TAVI is still limited to a few years, the opportunity of a second percutaneous treatment (TAVI-in-TAVI), extends the scope of percutaneous strategy. In the next few years, TAVI has to face many challenges to become a valid alternative to surgery in the younger patients as well.<\/jats:p>","DOI":"10.1093\/eurheartj\/suaa123","type":"journal-article","created":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T23:35:27Z","timestamp":1605742527000},"page":"L1-L5","source":"Crossref","is-referenced-by-count":16,"title":["Severe aortic stenosis in the young, with or without bicuspid valve: is transcatheter aortic valve implantation the first choice?"],"prefix":"10.1093","volume":"22","author":[{"given":"Igor","family":"Belluschi","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery, IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Buzzatti","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Castiglioni","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"De Bonis","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Montorfano","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology, IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University, Milan,\u00a0Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ottavio","family":"Alfieri","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,11,18]]},"reference":[{"key":"2021021716373429500_suaa123-B1","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1056\/NEJMoa1814052","article-title":"Transcatheter aortic-valve replacement with a balloon-expandable valve in low-risk patients","volume":"380","author":"Mack","year":"2019","journal-title":"N Eng J Med"},{"key":"2021021716373429500_suaa123-B2","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1056\/NEJMoa1816885","article-title":"Transcatheter aortic-valve replacement with a self-expanding valve in low-risk patients","volume":"380","author":"Popma","year":"2019","journal-title":"N Eng J Med"},{"key":"2021021716373429500_suaa123-B3","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1016\/j.jcin.2016.02.028","article-title":"Choice of treatment for aortic valve stenosis in the era of transcatheter aortic 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(EACTS","volume":"52","author":"Capodanno","year":"2017","journal-title":"Eur J Cardiothorac Surg"},{"key":"2021021716373429500_suaa123-B10","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1136\/heartjnl-2017-311329","article-title":"Structural valve deterioration after transcatheter aortic valve implantation","volume":"103","author":"Foroutan","year":"2017","journal-title":"Heart"},{"key":"2021021716373429500_suaa123-B11","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.jacc.2018.10.078","article-title":"Long-term durability of transcatheter aortic valve prostheses","volume":"73","author":"Blackman","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"2021021716373429500_suaa123-B12","doi-asserted-by":"crossref","first-page":"e003930.","DOI":"10.1161\/CIRCINTERVENTIONS.116.003930","article-title":"Outcomes of redo transcatheter aortic valve replacement for the treatment of postprocedural and late occurrence of paravalvular regurgitation and 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