{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:18:51Z","timestamp":1791274731248,"version":"4.1.0"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"Supplement_A","license":[{"start":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T00:00:00Z","timestamp":1616976000000},"content-version":"vor","delay-in-days":28,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Abiomed Europe GmbH"},{"name":"Abiomed GmbH"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,3,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The rationale for mechanical circulatory support (MCS) in cardiogenic shock is to restore cardiac output in selected patients when critically low or in case of refractory cardiac arrest. Furthermore, an MCS device that moves blood from either the left atrium or the left ventricle to the systemic circulation will potentially unload the ventricle. These devices are used alone or in combination with venoarterial extracorporeal membrane oxygenation (VA-ECMO). If a left-sided Impella device is used, it should be run at the highest possible performance level during treatment while avoiding suction events. When combined with VA-ECMO, the Impella device should be run at a lower performance level, ensuring sufficient left ventricular emptying but avoiding suction. Continuous monitoring is pivotal and patients managed outside the catheterization laboratory should be monitored with an arterial line, a central venous catheter, frequent use of pulmonary artery catheters and regular imaging by transthoracic echocardiogram.<\/jats:p>","DOI":"10.1093\/eurheartj\/suab004","type":"journal-article","created":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T08:07:12Z","timestamp":1617005232000},"page":"A23-A26","source":"Crossref","is-referenced-by-count":14,"title":["Pump flow setting and assessment of unloading in clinical practice"],"prefix":"10.1093","volume":"23","author":[{"given":"Jacob Eifer","family":"M\u00f8ller","sequence":"first","affiliation":[{"name":"Department of Cardiology, Odense University Hospital and Cardiac Intensive Care Unit, Heart Center, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej, DK - 2100 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Hassager","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Rigshospitalet, Blegdamsvej, DK - 2100 Copenhagen, Denmark"},{"name":"Department of Clinical Medicine, University of Copenhagen, Blegdamsvej, DK - 2100 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Bonello","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Aix-Marseille Universit\u00e9, Cardiac Intensive Care Unit, Assistance Publique-H\u00f4pitaux de Marseille, H\u00f4pital Nord, Mediterranean Association for Research and Studies in Cardiology (MARS Cardio), 80 Rue Brochier, 13005 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clement","family":"Delmas","sequence":"additional","affiliation":[{"name":"Intensive Cardiac Care Unit\u2014Acute and Chronic Mechanical Circulatory Support Team Rangueil University Hospital, Avenue du Professeur Jean Poulh\u00e8s, 31400 Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Pappalardo","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care, IRCCS ISMETT, UPMC Italy, Via Ernesto Tricomi, 5, 90127 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,3,27]]},"reference":[{"key":"2021070721255114200_suab004-B1","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1016\/S0140-6736(20)32338-2","article-title":"Advanced reperfusion strategies for patients with out-of-hospital cardiac arrest and refractory ventricular fibrillation (ARREST): a phase 2, single centre, open-label, randomised controlled 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ventricular function, and prevents subsequent heart failure in dogs","volume":"11","author":"Saku","year":"2018","journal-title":"Circulation"},{"key":"2021070721255114200_suab004-B5","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1161\/CIRCULATIONAHA.112.000029","article-title":"Mechanically unloading the left ventricle before coronary reperfusion reduces left ventricular wall stress and myocardial infarct size","volume":"128","author":"Kapur","year":"2013","journal-title":"Circulation"},{"key":"2021070721255114200_suab004-B6","first-page":"873","article-title":"Mechanical pre-conditioning with acute circulatory support before reperfusion limits infarct size in acute myocardial infarction","volume":"3","author":"Kapur","year":"2015","journal-title":"JACC"},{"key":"2021070721255114200_suab004-B7","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.jacc.2020.06.031","article-title":"Transvalvular ventricular unloading before reperfusion in acute myocardial infarction","volume":"76","author":"Swain","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"2021070721255114200_suab004-B8","first-page":"1035","article-title":"Unloading of the left ventricle during venoarterial extracorporeal membrane oxygenation therapy in cardiogenic shock","volume":"6","author":"Schrage","year":"2018","journal-title":"JACC"},{"key":"2021070721255114200_suab004-B9","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/s13054-020-2816-8","article-title":"Impact of concomitant vasoactive treatment and mechanical left ventricular unloading in a porcine model of profound cardiogenic shock","volume":"24","author":"Udesen","year":"2020","journal-title":"Crit Care"}],"container-title":["European Heart Journal 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