{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T23:41:05Z","timestamp":1784763665977,"version":"3.55.0"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"Supplement_A","license":[{"start":{"date-parts":[[2019,2,26]],"date-time":"2019-02-26T00:00:00Z","timestamp":1551139200000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,2,1]]},"DOI":"10.1093\/eurheartj\/suy035","type":"journal-article","created":{"date-parts":[[2019,2,26]],"date-time":"2019-02-26T11:02:28Z","timestamp":1551178948000},"page":"A28-A33","source":"Crossref","is-referenced-by-count":28,"title":["Pharmacology of new treatments for hyperkalaemia: patiromer and sodium zirconium cyclosilicate"],"prefix":"10.1093","volume":"21","author":[{"given":"Giuseppe M C","family":"Rosano","sequence":"first","affiliation":[{"name":"Department of Medical Sciences, Centre for Clinical and Basic Research, IRCCS San Raffaele Pisana, via della Pisana, 235, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Spoletini","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Centre for Clinical and Basic Research, IRCCS San Raffaele Pisana, via della Pisana, 235, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Agewall","sequence":"additional","affiliation":[{"name":"Oslo University Hospital Ullev\u00e5l and Institute of Clinical Sciences, University of Oslo, Postboks 4956 Nydalen, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,2,26]]},"reference":[{"key":"key\n\t\t\t\t2019022808504686900_suy035-B1","doi-asserted-by":"crossref","DOI":"10.1093\/ehjcvp\/pvy019","article-title":"New potassium binders reduce the risk of hyperkalaemia in patients treated with renin-angiotensin-aldosterone system inhibitors","author":"Tamargo","year":"2018","journal-title":"Eur Heart J Cardiovasc Pharmacother"},{"key":"key\n\t\t\t\t2019022808504686900_suy035-B2","first-page":"s307","article-title":"The burden of hyperkalemia in patients with cardiovascular and renal disease","volume":"21","author":"Dunn","year":"2015","journal-title":"Am J Manag Care"},{"key":"key\n\t\t\t\t2019022808504686900_suy035-B3","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1093\/ehjcvp\/pvw016","article-title":"Mineralocorticoid receptor antagonists in patients with heart failure: current experience and future perspectives","volume":"3","author":"Pitt","year":"2017","journal-title":"Eur Heart J Cardiovasc Pharmacother"},{"key":"key\n\t\t\t\t2019022808504686900_suy035-B4","first-page":"249","article-title":"New drugs for the treatment of hyperkalemia in patients treated with renin-angiotensin-aldosterone system inhibitors\u2014hype or hope?","volume":"18","author":"Tamargo","year":"2014","journal-title":"Discov Med"},{"key":"key\n\t\t\t\t2019022808504686900_suy035-B5","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1093\/ehjcvp\/pvy015","article-title":"Expert consensus document on the management of hyperkalaemia in patients with cardiovascular disease treated with renin angiotensin aldosterone system inhibitors: coordinated by the Working Group on Cardiovascular Pharmacotherapy of the European Society of Cardiology","volume":"4","author":"Rosano","year":"2018","journal-title":"Eur Heart J Cardiovasc Pharmacother"},{"key":"key\n\t\t\t\t2019022808504686900_suy035-B6","first-page":"S1","article-title":"K\/DOQI clinical practice guidelines on hypertension and antihypertensive agents in chronic kidney disease","volume":"43","year":"2004","journal-title":"Am J Kidney Dis"},{"key":"key\n\t\t\t\t2019022808504686900_suy035-B7","first-page":"IV1","article-title":"2005 American Heart Association guidelines for cardiopulmonary resuscitation and emergency cardiovascular care","volume":"112","year":"2005","journal-title":"Circulation"},{"key":"key\n\t\t\t\t2019022808504686900_suy035-B8","article-title":"Clinical Practice Guidelines: treatment of Acute Hyperkalaemia in Adults","year":"2014"},{"key":"key\n\t\t\t\t2019022808504686900_suy035-B9","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1681\/ASN.2010010079","article-title":"Ion-exchange resins for the treatment of hyperkalemia: are they safe and effective?","volume":"21","author":"Sterns","year":"2010","journal-title":"J Am Soc Nephrol"},{"key":"key\n\t\t\t\t2019022808504686900_suy035-B10","doi-asserted-by":"crossref","first-page":"4294","DOI":"10.1093\/ndt\/gfs293","article-title":"Asking the question again: are cation exchange resins effective for the treatment of hyperkalemia?","volume":"27","author":"Kamel","year":"2012","journal-title":"Nephrol Dial Transplant"},{"key":"key\n\t\t\t\t2019022808504686900_suy035-B11","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1093\/eurheartj\/ehw128","article-title":"2016 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure: the task force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) developed with the special contribution of the Heart Failure Association (HFA) of the ESC","volume":"37","author":"Ponikowski","year":"2016","journal-title":"Eur Heart J"},{"key":"key\n\t\t\t\t2019022808504686900_suy035-B12","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1177\/1074248416629549","article-title":"Mechanism of action and pharmacology of patiromer, a nonabsorbed cross-linked polymer that lowers serum potassium concentration in patients with hyperkalemia","volume":"21","author":"Li","year":"2016","journal-title":"J Cardiovasc Pharmacol Ther"},{"key":"key\n\t\t\t\t2019022808504686900_suy035-B13","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1185\/03007995.2015.1106935","article-title":"Patiromer: a clinical review","volume":"32","author":"Montaperto","year":"2016","journal-title":"Curr Med Res Opin"},{"key":"key\n\t\t\t\t2019022808504686900_suy035-B14","doi-asserted-by":"crossref","first-page":"11","DOI":"10.2147\/CE.S129555","article-title":"Clinical utility of patiromer, sodium zirconium cyclosilicate, and sodium polystyrene sulfonate for the treatment of hyperkalemia: an evidence-based review","volume":"12","author":"Beccari","year":"2017","journal-title":"Core Evid"},{"key":"key\n\t\t\t\t2019022808504686900_suy035-B15","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1093\/eurheartj\/ehq502","article-title":"Evaluation of the efficacy and safety of RLY5016, a polymeric potassium binder, in a double-blind, placebo-controlled study in patients with chronic heart failure (the PEARL-HF) trial","volume":"32","author":"Pitt","year":"2011","journal-title":"Eur Heart J"},{"key":"key\n\t\t\t\t2019022808504686900_suy035-B16","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1056\/NEJMoa1410853","article-title":"Patiromer in patients with kidney disease and hyperkalemia receiving RAAS inhibitors","volume":"372","author":"Weir","year":"2015","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019022808504686900_suy035-B17","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1001\/jama.2015.7446","article-title":"Effect of patiromer on serum potassium level in patients with hyperkalemia and diabetic kidney disease: the AMETHYST-DN randomized clinical trial","volume":"314","author":"Bakris","year":"2015","journal-title":"JAMA"},{"key":"key\n\t\t\t\t2019022808504686900_suy035-B18","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.amjmed.2017.11.011","article-title":"Effect of patiromer on hyperkalemia recurrence in older chronic kidney disease patients taking RAAS inhibitors","volume":"131","author":"Weir","year":"2018","journal-title":"Am J Med"},{"key":"key\n\t\t\t\t2019022808504686900_suy035-B19","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1080\/14740338.2018.1462335","article-title":"The tolerability and safety profile of patiromer: a novel polymer-based potassium binder for the treatment of hyperkalemia","volume":"17","author":"Pitt","year":"2018","journal-title":"Expert Opin Drug Saf"},{"key":"key\n\t\t\t\t2019022808504686900_suy035-B20","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1177\/1074248417691135","article-title":"Evaluation of the potential for drug interactions with patiromer in healthy volunteers","volume":"22","author":"Lesko","year":"2017","journal-title":"J Cardiovasc Pharmacol Ther"},{"key":"key\n\t\t\t\t2019022808504686900_suy035-B21","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1002\/phar.1906","article-title":"Systematic review and meta-analysis of patiromer and sodium zirconium cyclosilicate: a new armamentarium for the treatment of hyperkalemia","volume":"37","author":"Meaney","year":"2017","journal-title":"Pharmacotherapy"},{"key":"key\n\t\t\t\t2019022808504686900_suy035-B22","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1002\/phar.1797","article-title":"Sodium zirconium cyclosilicate (ZS-9): a novel agent for the treatment of hyperkalemia","volume":"36","author":"Linder","year":"2016","journal-title":"Pharmacotherapy"},{"key":"key\n\t\t\t\t2019022808504686900_suy035-B23","doi-asserted-by":"crossref","first-page":"e114686.","DOI":"10.1371\/journal.pone.0114686","article-title":"Characterization of structure and function of ZS-9, a K+ selective ion trap","volume":"9","author":"Stavros","year":"2014","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t2019022808504686900_suy035-B24","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1001\/jama.2014.15688","article-title":"Effect of sodium zirconium cyclosilicate on potassium lowering for 28 days among outpatients with hyperkalemia: the harmonize randomized clinical trial","volume":"312","author":"Kosiborod","year":"2014","journal-title":"JAMA"},{"key":"key\n\t\t\t\t2019022808504686900_suy035-B25","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1002\/ejhf.300","article-title":"Maintenance of serum potassium with sodium zirconium cyclosilicate (ZS-9) in heart failure patients: results from a phase 3 randomized, double-blind, placebo-controlled trial","volume":"17","author":"Anker","year":"2015","journal-title":"Eur J Heart Fail"},{"key":"key\n\t\t\t\t2019022808504686900_suy035-B26","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1056\/NEJMoa1411487","article-title":"Sodium zirconium cyclosilicate in hyperkalemia","volume":"372","author":"Packham","year":"2015","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019022808504686900_suy035-B27","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/ki.2014.382","article-title":"A phase 2 study on the treatment of hyperkalemia in patients with chronic kidney disease suggests that the selective potassium trap, ZS-9, is safe and efficient","volume":"88","author":"Ash","year":"2015","journal-title":"Kidney Int"},{"key":"key\n\t\t\t\t2019022808504686900_suy035-B28","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1093\/eurheartj\/ehy100","article-title":"Serum potassium and adverse outcomes across the range of kidney function: a CKD prognosis consortium meta-analysis","volume":"39","author":"Kovesdy","year":"2018","journal-title":"Eur Heart J"}],"container-title":["European Heart Journal Supplements"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/eurheartjsupp\/article-pdf\/21\/Supplement_A\/A28\/27994227\/suy035.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,2,28]],"date-time":"2019-02-28T13:57:14Z","timestamp":1551362234000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eurheartjsupp\/article\/21\/Supplement_A\/A28\/5364191"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,1]]},"references-count":28,"journal-issue":{"issue":"Supplement_A","published-online":{"date-parts":[[2019,2,26]]},"published-print":{"date-parts":[[2019,2,1]]}},"URL":"https:\/\/doi.org\/10.1093\/eurheartj\/suy035","relation":{},"ISSN":["1520-765X","1554-2815"],"issn-type":[{"value":"1520-765X","type":"print"},{"value":"1554-2815","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,2]]},"published":{"date-parts":[[2019,2,1]]}}}