{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:41:46Z","timestamp":1791315706288,"version":"4.3.1"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"Supplement_C","license":[{"start":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T00:00:00Z","timestamp":1682467200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Dilated cardiomyopathy is a primitive heart muscle condition, characterized by structural and functional abnormalities, in the absence of a specific cause sufficient to determine the disease. It is, though, an \u2018umbrella\u2019 term that describes the final common pathway of different pathogenic processes and gene\u2013environment interactions. Performing an accurate diagnostic workup and appropriate characterization of the patient has a direct impact on the patient\u2019s outcome. The physician should adapt a multiparametric approach, including a careful anamnesis and physical examination and integrating imaging data and genetic testing. Aetiological characterization should be pursued, and appropriate arrhythmic risk stratification should be performed. Evaluations should be repeated thoroughly at follow-up, as the disease is dynamical over time and individual risk might evolve. The goal is an all-around characterization of the patient, a personalized medicine approach, in order to establish a diagnosis and therapy tailored for the individual patient.<\/jats:p>","DOI":"10.1093\/eurheartjsupp\/suad016","type":"journal-article","created":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T17:35:52Z","timestamp":1682530552000},"page":"C137-C143","source":"Crossref","is-referenced-by-count":4,"title":["New perspectives in diagnosis and risk stratification of non-ischaemic dilated cardiomyopathy"],"prefix":"10.1093","volume":"25","author":[{"given":"Carola","family":"Pio Loco detto Gava","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Merlo","sequence":"additional","affiliation":[{"name":"Cardiothoracovascular Department, Cardiology, Giuliano Isontina University Health Authority (ASUGI), European Reference Network for rare, low-prevalence, or complex diseases of the Heart (ERN GUARD-Heart), University of Trieste , Via Pietro Valdoni, 7, 34149 Trieste (TS) , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Paldino","sequence":"additional","affiliation":[{"name":"Cardiothoracovascular Department, Cardiology, Giuliano Isontina University Health Authority (ASUGI), European Reference Network for rare, low-prevalence, or complex diseases of the Heart (ERN GUARD-Heart), University of Trieste , Via Pietro Valdoni, 7, 34149 Trieste (TS) , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata","family":"Korcova","sequence":"additional","affiliation":[{"name":"Cardiothoracovascular Department, Cardiology, Giuliano Isontina University Health Authority (ASUGI), European Reference Network for rare, low-prevalence, or complex diseases of the Heart (ERN GUARD-Heart), University of Trieste , Via Pietro Valdoni, 7, 34149 Trieste (TS) , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Massa","sequence":"additional","affiliation":[{"name":"Cardiothoracovascular Department, Cardiology, Giuliano Isontina University Health Authority (ASUGI), European Reference Network for rare, low-prevalence, or complex diseases of the Heart (ERN GUARD-Heart), University of Trieste , Via Pietro Valdoni, 7, 34149 Trieste (TS) , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aldostefano","family":"Porcari","sequence":"additional","affiliation":[{"name":"Cardiothoracovascular Department, Cardiology, Giuliano Isontina University Health Authority (ASUGI), European Reference Network for rare, low-prevalence, or complex diseases of the Heart (ERN GUARD-Heart), University of Trieste , Via Pietro Valdoni, 7, 34149 Trieste (TS) , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Zecchin","sequence":"additional","affiliation":[{"name":"Cardiothoracovascular Department, Cardiology, Giuliano Isontina University Health Authority (ASUGI), European Reference Network for rare, low-prevalence, or complex diseases of the Heart (ERN GUARD-Heart), University of Trieste , Via Pietro Valdoni, 7, 34149 Trieste (TS) , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Perotto","sequence":"additional","affiliation":[{"name":"Cardiothoracovascular Department, Cardiology, Giuliano Isontina University Health Authority (ASUGI), European Reference Network for rare, low-prevalence, or complex diseases of the Heart (ERN GUARD-Heart), University of Trieste , Via Pietro Valdoni, 7, 34149 Trieste (TS) , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maddalena","family":"Rossi","sequence":"additional","affiliation":[{"name":"Cardiothoracovascular Department, Cardiology, Giuliano Isontina University Health Authority (ASUGI), European Reference Network for rare, low-prevalence, or complex diseases of the Heart (ERN GUARD-Heart), University of Trieste , Via Pietro Valdoni, 7, 34149 Trieste (TS) , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianfranco","family":"Sinagra","sequence":"additional","affiliation":[{"name":"Cardiothoracovascular Department, Cardiology, Giuliano Isontina University Health Authority (ASUGI), European Reference Network for rare, low-prevalence, or complex diseases of the Heart (ERN GUARD-Heart), University of Trieste , Via Pietro Valdoni, 7, 34149 Trieste (TS) , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,4,26]]},"reference":[{"key":"2023042617351159500_suad016-B1","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1161\/CIRCULATIONAHA.106.174287","article-title":"Contemporary definitions and classification of the cardiomyopathies: an American Heart Association scientific statement from the Council on Clinical Cardiology, Heart Failure and Transplantation Committee; quality of care and outcomes research and functional genomics and translational biology interdisciplinary working groups; and council on epidemiology and prevention","volume":"113","author":"Maron","year":"2006","journal-title":"Circulation"},{"key":"2023042617351159500_suad016-B2","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1002\/ejhf.1103","article-title":"Evolving concepts in dilated cardiomyopathy","volume":"20","author":"Merlo","year":"2018","journal-title":"Eur J Heart Fail"},{"key":"2023042617351159500_suad016-B3","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1093\/eurheartj\/ehm342","article-title":"Classification of the cardiomyopathies: a position statement from the European Society of Cardiology working group on myocardial and pericardial diseases","volume":"29","author":"Elliott","year":"2007","journal-title":"Eur Heart J"},{"key":"2023042617351159500_suad016-B4","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1093\/eurheartj\/ehv727","article-title":"Proposal for a revised definition of dilated cardiomyopathy, hypokinetic non-dilated cardiomyopathy, and its implications for clinical practice: a position statement of the ESC working group on myocardial and pericardial diseases","volume":"37","author":"Pinto","year":"2016","journal-title":"Eur Heart J"},{"key":"2023042617351159500_suad016-B5","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.hrthm.2019.07.019","article-title":"The electrocardiogram in the diagnosis and management of patients with hypertrophic cardiomyopathy","volume":"17","author":"Finocchiaro","year":"2020","journal-title":"Heart Rhythm"},{"key":"2023042617351159500_suad016-B6","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1161\/CIRCULATIONAHA.113.002518","article-title":"The prevalence and prognostic significance of right ventricular systolic dysfunction in nonischemic dilated cardiomyopathy","volume":"128","author":"Gulati","year":"2013","journal-title":"Circulation"},{"key":"2023042617351159500_suad016-B7","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1093\/eurjhf\/hft019","article-title":"Clinical utility and prognostic value of left atrial volume assessment by cardiovascular magnetic resonance in non-ischaemic dilated cardiomyopathy","volume":"15","author":"Gulati","year":"2013","journal-title":"Eur J Heart Fail"},{"key":"2023042617351159500_suad016-B8","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.ijcard.2020.09.036","article-title":"High prevalence of subtle systolic and diastolic dysfunction in genotype-positive phenotype-negative relatives of dilated cardiomyopathy patients","volume":"324","author":"Paldino","year":"2021","journal-title":"Int J Cardiol"},{"key":"2023042617351159500_suad016-B9","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.jcmg.2019.02.032","article-title":"Value of speckle tracking-based deformation analysis in screening relatives of patients with asymptomatic dilated cardiomyopathy","volume":"13","author":"Verdonschot","year":"2020","journal-title":"JACC Cardiovasc Imaging"},{"key":"2023042617351159500_suad016-B10","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.1161\/CIRCULATIONAHA.116.026910","article-title":"Association between midwall late gadolinium enhancement and sudden cardiac death in patients with dilated cardiomyopathy and mild and moderate left ventricular systolic dysfunction","volume":"135","author":"Halliday","year":"2017","journal-title":"Circulation"},{"key":"2023042617351159500_suad016-B11","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.119.010105","article-title":"Prognostic value of late gadolinium enhancement for the prediction of cardiovascular outcomes in dilated cardiomyopathy: an international, multi-institutional study of the MINICOR group","volume":"13","author":"Alba","year":"2020","journal-title":"Circ Cardiovasc Imaging"},{"key":"2023042617351159500_suad016-B12","doi-asserted-by":"crossref","first-page":"2890","DOI":"10.1016\/j.jacc.2021.04.030","article-title":"Improved risk stratification for ventricular arrhythmias and sudden death in patients with nonischemic dilated cardiomyopathy","volume":"77","author":"Di Marco","year":"2021","journal-title":"J Am Coll Cardiol"},{"key":"2023042617351159500_suad016-B13","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.121.021370","article-title":"Endomyocardial biopsy: the forgotten piece in the arrhythmogenic cardiomyopathy puzzle","volume":"10","author":"Casella","year":"2021","journal-title":"J Am Heart Assoc"},{"key":"2023042617351159500_suad016-B14","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1002\/ejhf.2380","article-title":"Standardizing the role of endomyocardial biopsy in current clinical practice worldwide","volume":"23","author":"Sinagra","year":"2021","journal-title":"Eur J Heart Fail"},{"key":"2023042617351159500_suad016-B15","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1093\/europace\/euaa343","article-title":"\u2018Hot phase\u2019 clinical presentation in arrhythmogenic cardiomyopathy","volume":"23","author":"Bariani","year":"2021","journal-title":"EP Europace"},{"key":"2023042617351159500_suad016-B16","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1002\/ejhf.1914","article-title":"Contemporary survival trends and aetiological characterization in non-ischaemic dilated cardiomyopathy","volume":"22","author":"Merlo","year":"2020","journal-title":"Eur J Heart Fail"},{"key":"2023042617351159500_suad016-B17","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.cardfail.2009.01.006","article-title":"Genetic evaluation of cardiomyopathy\u2014a Heart Failure Society of America practice guideline","volume":"15","author":"Hershberger","year":"2009","journal-title":"J Card Fail"},{"key":"2023042617351159500_suad016-B18","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1161\/CIRCULATIONAHA.121.053521","article-title":"Phenotypic expression, natural history, and risk stratification of cardiomyopathy caused by Filamin C truncating variants","volume":"144","author":"Gigli","year":"2021","journal-title":"Circulation"},{"key":"2023042617351159500_suad016-B19","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1161\/CIRCULATIONAHA.121.056072","article-title":"Long-term follow-up of DANISH (the Danish study to assess the efficacy of ICDs in patients with nonischemic systolic heart failure on mortality)","volume":"145","author":"Yafasova","year":"2022","journal-title":"Circulation"},{"key":"2023042617351159500_suad016-B20","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.115.002149","article-title":"Arrhythmogenic phenotype in dilated cardiomyopathy: natural history and predictors of life-threatening arrhythmias","volume":"4","author":"Spezzacatene","year":"2015","journal-title":"J Am Heart Assoc"}],"container-title":["European Heart Journal Supplements"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/eurheartjsupp\/article-pdf\/25\/Supplement_C\/C137\/50100146\/suad016.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eurheartjsupp\/article-pdf\/25\/Supplement_C\/C137\/50100146\/suad016.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T17:36:06Z","timestamp":1682530566000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eurheartjsupp\/article\/25\/Supplement_C\/C137\/7143261"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,26]]},"references-count":20,"journal-issue":{"issue":"Supplement_C","published-online":{"date-parts":[[2023,4,26]]},"published-print":{"date-parts":[[2023,4,26]]}},"URL":"https:\/\/doi.org\/10.1093\/eurheartjsupp\/suad016","relation":{},"ISSN":["1520-765X","1554-2815"],"issn-type":[{"value":"1520-765X","type":"print"},{"value":"1554-2815","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,5,1]]},"published":{"date-parts":[[2023,4,26]]}}}