{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:41:45Z","timestamp":1791315705094,"version":"4.3.1"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"Supplement_C","license":[{"start":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T00:00:00Z","timestamp":1682467200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The designation of \u2018arrhythmogenic cardiomyopathy\u2019 reflects the evolving concept of a heart muscle disease affecting not only the right ventricle (ARVC) but also the left ventricle (LV), with phenotypic variants characterized by a biventricular (BIV) or predominant LV involvement (ALVC). Herein, we use the term \u2018scarring\/arrhythmogenic cardiomyopathy (S\/ACM)\u2019 to emphasize that the disease phenotype is distinctively characterized by loss of ventricular myocardium due to myocyte death with subsequent fibrous or fibro-fatty scar tissue replacement. The myocardial scarring predisposes to potentially lethal ventricular arrhythmias and underlies the impairment of systolic ventricular function. S\/ACM is an \u2018umbrella term\u2019 which includes a variety of conditions, either genetic or acquired (mostly post-inflammatory), sharing the typical \u2018scarring\u2019 phenotypic features of the disease. Differential diagnoses include \u2018non-scarring\u2019 heart diseases leading to either RV dilatation from left-to-right shunt or LV dilatation\/dysfunction from a dilated cardiomyopathy. The development of 2020 upgraded criteria (\u2018Padua criteria\u2019) for diagnosis of S\/ACM reflected the evolving clinical experience with the expanding spectrum of S\/ACM phenotypes and the advances in cardiac magnetic resonance (CMR) imaging. The Padua criteria aimed to improve the diagnosis of S\/ACM by incorporation of CMR myocardial tissue characterization findings. Risk stratification of S\/ACM patients is mostly based on arrhythmic burden and ventricular dysfunction severity, although other ECG or imaging parameters may have a role. Medical therapy is crucial for treatment of ventricular arrhythmias and heart failure. Implantable cardioverter defibrillator (ICD) is the only proven life-saving treatment, despite its significant morbidity because of device-related complications and inappropriate shocks. Selection of patients who can benefit the most from ICD therapy is one of the most challenging issues in clinical practice.<\/jats:p>","DOI":"10.1093\/eurheartjsupp\/suad017","type":"journal-article","created":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T14:00:47Z","timestamp":1674655247000},"page":"C144-C154","source":"Crossref","is-referenced-by-count":35,"title":["Scarring\/arrhythmogenic cardiomyopathy"],"prefix":"10.1093","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1487-0392","authenticated-orcid":false,"given":"Domenico","family":"Corrado","sequence":"first","affiliation":[{"name":"Department of Cardiac, Thoracic and Vascular Sciences and Public Health, University of Padova , Via Giustiniani 2, 35121 Padova , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Zorzi","sequence":"additional","affiliation":[{"name":"Department of Cardiac, Thoracic and Vascular Sciences and Public Health, University of Padova , Via Giustiniani 2, 35121 Padova , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Cipriani","sequence":"additional","affiliation":[{"name":"Department of Cardiac, Thoracic and Vascular Sciences and Public Health, University of Padova , Via Giustiniani 2, 35121 Padova , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Bauce","sequence":"additional","affiliation":[{"name":"Department of Cardiac, Thoracic and Vascular Sciences and Public Health, University of Padova , Via Giustiniani 2, 35121 Padova , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Bariani","sequence":"additional","affiliation":[{"name":"Department of Cardiac, Thoracic and Vascular Sciences and Public Health, University of Padova , Via Giustiniani 2, 35121 Padova , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Brunetti","sequence":"additional","affiliation":[{"name":"Department of Cardiac, Thoracic and Vascular Sciences and Public Health, University of Padova , Via Giustiniani 2, 35121 Padova , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Graziano","sequence":"additional","affiliation":[{"name":"Department of Cardiac, Thoracic and Vascular Sciences and Public Health, University of Padova , Via Giustiniani 2, 35121 Padova , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"De Lazzari","sequence":"additional","affiliation":[{"name":"Department of Cardiac, Thoracic and Vascular Sciences and Public Health, University of Padova , Via Giustiniani 2, 35121 Padova , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Mattesi","sequence":"additional","affiliation":[{"name":"Department of Cardiac, Thoracic and Vascular Sciences and Public Health, University of Padova , Via Giustiniani 2, 35121 Padova , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Migliore","sequence":"additional","affiliation":[{"name":"Department of Cardiac, Thoracic and Vascular Sciences and Public Health, University of Padova , Via Giustiniani 2, 35121 Padova , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalliopi","family":"Pilichou","sequence":"additional","affiliation":[{"name":"Department of Cardiac, Thoracic and Vascular Sciences and Public Health, University of Padova , Via Giustiniani 2, 35121 Padova , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Rigato","sequence":"additional","affiliation":[{"name":"Department of Cardiac, Thoracic and Vascular Sciences and Public Health, University of Padova , Via Giustiniani 2, 35121 Padova , 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