{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T18:12:36Z","timestamp":1794334356435,"version":"4.9.0"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"Supplement_C","license":[{"start":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T00:00:00Z","timestamp":1682467200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The standard 12-lead electrocardiogram (ECG) represents a cornerstone for the diagnosis and evaluation of hypertrophic cardiomyopathy (HCM), the most common genetically determined heart muscle disease, due to its cost-effectiveness and wide availability. The ECG may surprisingly look normal in 4\u20136% of adult patients, and in less than 3% of paediatric patients, but it is abnormal in the vast majority of the remaining patients. \u2018Specific\u2019 features comprise pathological Q-waves, deep S-waves in V1\u2013V3, or high R-waves in V4\u2013V6 due to left ventricular hypertrophy with T-wave (TW) depression or negative TWs. Negative giant TWs are often found in apical HCM. However, in many patients, the ECG may only show non-specific ST\u2013T changes with diphasic or flat TWs. An isolated inverted TW in lateral leads (usually aVL) may be the only marker for HCM in some patients. Electrocardiogram helps to diagnose sarcomeric HCM and distinguish it from different phenocopies, such as cardiac amyloidosis, glycogen storage, or Fabry disease. Electrocardiogram may also have a prognostic role, identifying high-risk features that could impact the clinical outcome.<\/jats:p>","DOI":"10.1093\/eurheartjsupp\/suad074","type":"journal-article","created":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T17:37:19Z","timestamp":1682530639000},"page":"C173-C178","source":"Crossref","is-referenced-by-count":34,"title":["Diagnostic and prognostic electrocardiographic features in patients with hypertrophic cardiomyopathy"],"prefix":"10.1093","volume":"25","author":[{"given":"Andrea","family":"Bernardini","sequence":"first","affiliation":[{"name":"Cardiology and Electrophysiology Unit, Santa Maria Nuova Hospital , Piazza di Santa Maria Nuova 1, 50122 Florence , Italy"},{"name":"Department of Experimental and Clinical Medicine, University of Florence , Largo Giovanni Alessandro Brambilla 3, 50134 Florence , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lia","family":"Crotti","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, University Milano Bicocca , Piazza dell\u2019Ateneo Nuovo 1, 20126 Milan , Italy"},{"name":"IRCCS Istituto Auxologico Italiano, Department of Cardiology , San Luca Hospital, Piazzale Brescia 20, 20149 Milan , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iacopo","family":"Olivotto","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine, University of Florence , Largo Giovanni Alessandro Brambilla 3, 50134 Florence , Italy"},{"name":"Meyer Children\u2019s Hospital IRCCS, Viale Gaetano Pieraccini 24 , 50139 Florence , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Cecchi","sequence":"additional","affiliation":[{"name":"IRCCS Istituto Auxologico Italiano, Department of Cardiology , San Luca Hospital, Piazzale Brescia 20, 20149 Milan , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,4,26]]},"reference":[{"key":"2024040610055082000_suad074-B1","first-page":"e558","article-title":"2020 AHA\/ACC guideline for the diagnosis and treatment of patients with hypertrophic cardiomyopathy","volume":"142","author":"Ommen","year":"2020","journal-title":"Circulation"},{"key":"2024040610055082000_suad074-B2","doi-asserted-by":"crossref","first-page":"2733","DOI":"10.1093\/eurheartj\/ehu284","article-title":"2014 ESC guidelines on diagnosis and management of hypertrophic cardiomyopathy: the Task Force for the Diagnosis and Management of Hypertrophic Cardiomyopathy of the European Society of Cardiology (ESC)","volume":"35","author":"Elliott","year":"2014","journal-title":"Eur Heart J"},{"key":"2024040610055082000_suad074-B3","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1056\/NEJM199808063390602","article-title":"Screening for hypertrophic cardiomyopathy in young athletes","volume":"339","author":"Corrado","year":"1998","journal-title":"N Engl J Med"},{"key":"2024040610055082000_suad074-B4","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1161\/CIRCULATIONAHA.118.037264","article-title":"Clinical course and significance of hypertrophic cardiomyopathy without left ventricular hypertrophy","volume":"139","author":"Maurizi","year":"2019","journal-title":"Circulation"},{"key":"2024040610055082000_suad074-B5","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.hrthm.2019.07.019","article-title":"The electrocardiogram in the diagnosis and management of patients with hypertrophic cardiomyopathy","volume":"17","author":"Finocchiaro","year":"2020","journal-title":"Heart Rhythm"},{"key":"2024040610055082000_suad074-B6","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1093\/eurheartj\/ehs397","article-title":"Diagnostic work-up in cardiomyopathies: bridging the gap between clinical phenotypes and final diagnosis. 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