{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:07:59Z","timestamp":1760123279548},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"Supplement_B","license":[{"start":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T00:00:00Z","timestamp":1682035200000},"content-version":"vor","delay-in-days":20,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The combination of an initial clinical approach aimed at evaluating the early risk of mortality with subsequent diagnostic and therapeutic approaches articulated on the overall patient\u2019s profile is recommended in acute pulmonary embolism (PE). The presence of pulmonary hypertension associated with the persistence of chronic vascular obstructions in the pulmonary arteries after one or more acute thrombo-embolic events identifies a condition defined as chronic thrombo-embolic pulmonary hypertension (CTEPH). The evolution of technology and knowledge in the field of imaging has allowed us to qualify the computed tomography angiography of the pulmonary arteries as the gold standard for the diagnostic confirmation of both acute PE and CTEPH. In both these conditions, the first therapeutic step is the immediate initiation of anticoagulant therapy. In acute high-risk PE, in addition to anticoagulant therapy, thrombolytic therapy is recommended; in the event of contraindications to thrombolysis, surgical embolectomy or percutaneous catheter-directed treatment represents viable treatment options. In CTEPH, the combination of data collected from cardiac catheterization, computed tomography angiography, and conventional angiography of pulmonary arteries allows a team of experts to identify candidates for pulmonary endarterectomy surgery. Inoperable patients should be considered for percutaneous balloon angioplasty of the pulmonary arteries which can improve patients\u2019 symptoms, quality of life, and prognosis.<\/jats:p>","DOI":"10.1093\/eurheartjsupp\/suad080","type":"journal-article","created":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T18:04:08Z","timestamp":1682100248000},"page":"B90-B94","source":"Crossref","is-referenced-by-count":1,"title":["Progress in the treatment of acute pulmonary embolism and chronic thrombo-embolic pulmonary hypertension\/disease"],"prefix":"10.1093","volume":"25","author":[{"given":"Massimiliano","family":"Palazzini","sequence":"first","affiliation":[{"name":"Cardiology Unit, IRCCS University Hospital of Bologna"},{"name":"DIMEC Department, University of Bologna"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Dardi","sequence":"additional","affiliation":[{"name":"Cardiology Unit, IRCCS University Hospital of Bologna"},{"name":"DIMEC Department, University of Bologna"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilenia","family":"Magnani","sequence":"additional","affiliation":[{"name":"Cardiology Unit, IRCCS University Hospital of Bologna"},{"name":"DIMEC Department, University of Bologna"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele","family":"Guarino","sequence":"additional","affiliation":[{"name":"Cardiology Unit, IRCCS University Hospital of Bologna"},{"name":"DIMEC Department, University of Bologna"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nazzareno","family":"Galie\u2019","sequence":"additional","affiliation":[{"name":"Cardiology Unit, IRCCS University Hospital of Bologna"},{"name":"DIMEC Department, University of Bologna"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Manes","sequence":"additional","affiliation":[{"name":"Cardiology Unit, IRCCS University Hospital of Bologna"},{"name":"DIMEC Department, University of Bologna"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,4,21]]},"reference":[{"key":"2023042117460089100_suad080-B1","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1161\/ATVBAHA.114.304488","article-title":"ISTH Steering Committee for World Thrombosis Day. Thrombosis: a major contributor to global disease burden","volume":"34","author":"Raskob","year":"2014","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2023042117460089100_suad080-B2","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1160\/TH07-03-0212","article-title":"VTE Impact Assessment Group in Europe (VITAE). Venous thromboembolism (VTE) in Europe. 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evidence","volume":"39","author":"Gali\u00e8","year":"2018","journal-title":"Eur Heart J"},{"key":"2023042117460089100_suad080-B12","doi-asserted-by":"crossref","first-page":"3618","DOI":"10.1093\/eurheartj\/ehac237","article-title":"2022 ESC\/ERS guidelines for the diagnosis and treatment of pulmonary hypertension","volume":"43","author":"Humbert","year":"2022","journal-title":"Eur Heart J"},{"key":"2023042117460089100_suad080-B13","doi-asserted-by":"crossref","first-page":"1801915","DOI":"10.1183\/13993003.01915-2018","article-title":"Chronic thromboembolic pulmonary hypertension","volume":"53","author":"Kim","year":"2019","journal-title":"Eur Respir J"},{"key":"2023042117460089100_suad080-B14","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.jtcvs.2010.11.024","article-title":"Surgical management and outcome of patients with chronic thromboembolic pulmonary hypertension: results from an international prospective 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