{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:19:53Z","timestamp":1791559193621,"version":"4.3.4"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"Supplement_E","license":[{"start":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T00:00:00Z","timestamp":1684886400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010975","name":"National Institute for Research","doi-asserted-by":"publisher","award":["LX22NPO5104"],"award-info":[{"award-number":["LX22NPO5104"]}],"id":[{"id":"10.13039\/501100010975","id-type":"DOI","asserted-by":"publisher"}]},{"name":"European Union\u2014Next Generation EU"},{"name":"Charles University Cardiovascular Science"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The association between antithrombotics (ATs) and the risk of gastrointestinal bleeding is well known; however, data regarding the influence of ATs on outcomes are scarce. The goals of this study are: (i) to assess the impact of prior AT therapy on in-hospital and 6-month outcomes and (ii) to determine the re-initiation rate of the ATs after a bleeding event. All patients with upper gastrointestinal bleeding (UGB) who underwent urgent gastroscopy in three centres from 1 January 2019 to 31 December 2019 were retrospectively analysed. Propensity score matching (PSM) was used. Among 333 patients [60% males, mean age 69.2 (\u00b117.3) years], 44% were receiving ATs. In multivariate logistic regression, no association between AT treatment and worse in-hospital outcomes was observed. Development of haemorrhagic shock led to worse survival [odds ratio (OR) 4.4, 95% confidence interval (CI) 1.9\u201310.2, P &amp;lt; 0.001; after PSM: OR 5.3, 95% CI 1.8\u201315.7, P = 0.003]. During 6-months follow-up, higher age (OR 1.0, 95% CI 1.0\u20131.1, P = 0.002), higher comorbidity (OR 1.4, 95% CI 1.2\u20131.7, P &amp;lt; 0.001), a history of cancer (OR 3.6, 95% CI 1.6\u20138.1, P &amp;lt; 0.001) and a history of liver cirrhosis (OR 2.2, 95% CI 1.0\u20134.4, P = 0.029) were associated with higher mortality. After a bleeding episode, ATs were adequately re-initiated in 73.8%. Previous AT therapy does not worsen in-hospital outcomes in after UGB. Development of haemorrhagic shock predicted poor prognosis. Higher 6-month mortality was observed in older patients, patients with more comorbidities, with liver cirrhosis and cancer.<\/jats:p>","DOI":"10.1093\/eurheartjsupp\/suad103","type":"journal-article","created":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T09:48:46Z","timestamp":1684921726000},"page":"E25-E32","source":"Crossref","is-referenced-by-count":4,"title":["Previous antithrombotic therapy does not have an impact on the in-hospital mortality of patients with upper gastrointestinal bleeding"],"prefix":"10.1093","volume":"25","author":[{"given":"Marek","family":"Hozman","sequence":"first","affiliation":[{"name":"Cardiocenter, Hospital Karlovy Vary , 360 01 Karlovy Vary , Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabri","family":"Hassouna","sequence":"additional","affiliation":[{"name":"Cardiocenter, 3rd Faculty of Medicine, Charles University and University Hospital Kralovske Vinohrady , Ruska 87, 100 00 Prague , Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Grochol","sequence":"additional","affiliation":[{"name":"2nd Department of Internal Medicine, 3rd Faculty of Medicine, Charles University and University Hospital Kralovske Vinohrady , 100 00 Prague , Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petr","family":"Waldauf","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care, 3rd Faculty of Medicine, Charles University and University Hospital Kralovske Vinohrady , 100 00 Prague , Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Hracek","sequence":"additional","affiliation":[{"name":"Department of General Surgery, 3rd Faculty of Medicine, Charles University, Faculty Hospital Kralovske Vinohrady , 100 00 Prague , Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blanka Zborilova","family":"Pazdiorova","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hospital Karlovy Vary , 360 01 Karlovy Vary , Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanislav","family":"Adamec","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hospital Cheb , 350 02 Cheb , Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavel","family":"Osmancik","sequence":"additional","affiliation":[{"name":"Cardiocenter, 3rd Faculty of Medicine, Charles University and University Hospital Kralovske Vinohrady , Ruska 87, 100 00 Prague , Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,5,24]]},"reference":[{"key":"2023052409431798200_suad103-B1","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1007\/s10620-018-4951-5","article-title":"Epidemiology of upper gastrointestinal hemorrhage 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