{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T12:11:41Z","timestamp":1778069501000,"version":"3.51.4"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"Supplement_5","license":[{"start":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T00:00:00Z","timestamp":1773619200000},"content-version":"vor","delay-in-days":5,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The haemodynamic mechanisms underlying vasovagal (reflex) syncope include hypotension and extrinsic asystole\/bradycardia, corresponding to two distinct haemodynamic phenotypes of syncope, that is, the hypotensive and the bradycardic phenotypes. The hypotensive phenotype is the most prevalent, being observed in the 83% of patients. Twenty-four hours ambulatory blood pressure monitoring (ABPM) demonstrated high effectiveness in identifying the hypotensive phenotype in patients with suspected reflex syncope. The diagnosis of a hypotensive mechanism of syncope is supported by ABPM when one or more of the following criteria are present:. Constitutional hypotension: 24-h systolic blood pressure (SBP) &amp;lt; 105\u2005mmHg in men and &amp;lt;98 in women. Drug-related hypotension: 24-h SBP &amp;lt;120\u2005mmHg. Hypotensive episodes: \u22651 daytime SBP &amp;lt;90\u2005mmHg or \u22652 daytime SBP &amp;lt;100\u2005mmHg. Postprandial hypotension: symptomatic SBP fall &amp;gt;20\u2005mmHg or absolute value &amp;lt;90\u2005mmHg within 75\u2005min of meals. ABPM also plays a key role in guiding therapy. In hypertensive patients with hypotensive syncope, deprescribing antihypertensive medications is indicated with the goal of increasing 24-h average SBP to \u2265 134\u2005mmHg and\/or by at least \u226512\u2005mmHg, without exceeding 140\u2005mmHg (or &amp;lt;160\u2005mmHg in frail older patients). In patients with drug-unrelated hypotension, lower-body elastic garments, fludrocortisone, or midodrine\u2014prescribed singularly or in combination\u2014may be considered and targeted to achieve a 24-h average SBP \u2265116\u2005mmHg and\/or an increase of at least \u22659\u2005mmHg.<\/jats:p>","DOI":"10.1093\/eurheartjsupp\/suag025","type":"journal-article","created":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T12:42:38Z","timestamp":1771936958000},"page":"v48-v51","source":"Crossref","is-referenced-by-count":0,"title":["Vasovagal syncope: the role of 24\u2005h ambulatory blood pressure monitoring"],"prefix":"10.1093","volume":"28","author":[{"given":"Michele","family":"Brignole","sequence":"first","affiliation":[{"name":"IRCCS Istituto Auxologico Italiano, Dipartimento di Cardiologia, ospedale S. Luca , Piazzale Brescia 20, 20149 Milano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2736-2242","authenticated-orcid":false,"given":"Giulia","family":"Rivasi","sequence":"additional","affiliation":[{"name":"Universit\u00e0 di Firenze ed Azienda Ospedaliero Universitaria Careggi, Divisione di Geriatria e Medicina Intensiva , Firenze, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,3,11]]},"reference":[{"key":"2026050607112915900_suag025-B1","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1097\/HJH.0000000000002800","article-title":"Low-blood pressure phenotype underpins the tendency to reflex syncope","volume":"39","author":"Brignole","year":"2021","journal-title":"J Hypertens"},{"key":"2026050607112915900_suag025-B2","doi-asserted-by":"crossref","first-page":"17894","DOI":"10.1038\/s41598-021-97503-0","article-title":"Underlying hemodynamic 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