{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T17:48:07Z","timestamp":1793814487360,"version":"4.6.1"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2021,8,15]],"date-time":"2021-08-15T00:00:00Z","timestamp":1628985600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006020","name":"CTMM","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006020","id-type":"DOI","asserted-by":"crossref"}]},{"name":"TRIUMPH","award":["01C-103"],"award-info":[{"award-number":["01C-103"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,4,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>The relation between non-cardiac comorbidities and health-related quality of life (HRQoL) in patients with heart failure (HF) has been studied to a limited extent. To investigate the HRQoL and their determinants among HF patients with and without comorbidities.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>TRIUMPH (TRanslational Initiative on Unique and novel strategies for Management of Patients with Heart failure) is a Dutch prospective, multicentre study enrolling 496 acute HF patients between 2009 and 2014. We included 334 patients who had completed the HRQoL questionnaires at baseline. The HRQoL was measured by the Kansas City Cardiomyopathy Questionnaire (KCCQ) en EuroQuality-of-life five Dimensions (EQ-5D). Comorbidity was defined as having a history of at least one of the following comorbidities: chronic kidney disease, diabetes mellitus, chronic obstructive pulmonary disease (COPD), and\/or cerebrovascular accident. Patients with comorbidity (n\u2009=\u2009205, 61%) had lower scores on the physical limitation scale and clinical summary score of the KCCQ (P\u2009=\u20090.03 and P\u2009=\u20090.01, respectively). Female sex, COPD, previous HF, increasing body mass index (BMI), elevated N-terminal pro-B-type natriuretic peptide (NT-proBNP), high systolic blood pressure, and the presence of anxiety and\/or depression negatively influenced the HRQoL among HF patients with comorbidity. Besides anxiety and depression, we hardly found any other determinant of HRQoL in patients without comorbidity.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Heart failure patients without comorbidity had better HRQoL than patients with comorbidity. Sex, previous HF, BMI, COPD, systolic blood pressure, NT-proBNP levels, and also anxiety and depression were determinants of HRQoL in patients with comorbidity. In those without comorbidity, apart from anxiety and depression, no further determinants of HRQoL were found.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/eurjcn\/zvab061","type":"journal-article","created":{"date-parts":[[2021,7,13]],"date-time":"2021-07-13T03:12:02Z","timestamp":1626145922000},"page":"205-212","source":"Crossref","is-referenced-by-count":28,"title":["Determinants of quality of life in acute heart failure patients with and without comorbidities: a prospective, observational study"],"prefix":"10.1093","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7749-2785","authenticated-orcid":false,"given":"Jan C","family":"van den Berge","sequence":"first","affiliation":[{"name":"Department of Cardiology, Erasmus MC, University Medical Center Rotterdam, Dr. Molewaterplein 40, Rotterdam 3015 GD, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura C","family":"van Vark","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Erasmus MC, University Medical Center Rotterdam, Dr. Molewaterplein 40, Rotterdam 3015 GD, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douwe","family":"Postmus","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen 9713 GZ, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth M W J","family":"Utens","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry\/Psychology, Erasmus MC\u2014Sophia Children\u2019s Hospital, University Medical Center Rotterdam, Wytemaweg 8, Rotterdam 3015 CN, the Netherlands"},{"name":"Academic Center for Child Psychiatry the Bascule\/Department of Child and Adolescent Psychiatry, Academic Medical Center, Meibergdreef 5, Amsterdam, 1105 AZ, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans L","family":"Hillege","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen 9713 GZ, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2559-7128","authenticated-orcid":false,"given":"Eric","family":"Boersma","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Erasmus MC, University Medical Center Rotterdam, Dr. Molewaterplein 40, Rotterdam 3015 GD, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivonne","family":"Lesman-Leegte","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen 9713 GZ, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K Martijn","family":"Akkerhuis","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Erasmus MC, University Medical Center Rotterdam, Dr. Molewaterplein 40, Rotterdam 3015 GD, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,8,15]]},"reference":[{"key":"2022040910215330200_zvab061-B1","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1016\/j.jacc.2014.08.036","article-title":"Noncardiac comorbidities in heart failure with reduced versus preserved ejection fraction","volume":"64","author":"Mentz","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"2022040910215330200_zvab061-B2","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s10741-012-9370-7","article-title":"Co-morbidities in heart failure","volume":"19","author":"van Deursen","year":"2014","journal-title":"Heart Fail 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