{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T03:42:50Z","timestamp":1776570170914,"version":"3.51.2"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T00:00:00Z","timestamp":1654560000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001691","name":"KAKENHI","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science, and Technology","doi-asserted-by":"crossref","award":["19K11371"],"award-info":[{"award-number":["19K11371"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Impairment in activities of daily living (ADL) is an independent predictor of poor prognosis in older patients. Nevertheless, the effects of instrumental ADL (IADL) frequency on prognosis in older patients with cardiovascular disease (CVD) are unclear. We investigate the associations between IADL frequency and all-cause mortality and hospital readmission due to cardiovascular events in older patients with CVD.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>A total of 638 consecutive outpatients \u226565 years old with CVD were enrolled. A questionnaire, including Frenchay Activities Index (FAI) parameters, was used to determine IADL frequency at the start of the study as the baseline observation. The primary endpoint was all-cause mortality, and the secondary endpoint was readmission for cardiovascular events. We examined the relationship between IADL frequency and each endpoint. Among the 632 patients evaluated {median age 74.0 [interquartile range (IQR) 70.0\u201378.0] years; 439 males}, there were 39 deaths and 105 cardiovascular events during the median follow-up period of 4.0 (IQR, 2.3\u20134.0) years. After adjusting for clinical confounding factors, the hazard ratios for all-cause mortality and cardiovascular events in the FAI points were 0.957 [95% confidence interval (CI), 0.920\u20130.996] and 0.973 (95% CI, 0.950\u20130.997), respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>A higher IADL frequency was independently associated with better outcomes in older patients with CVD, suggesting that the preservation of instrumental activities should be focused on as the components of cardiovascular rehabilitation.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/eurjcn\/zvac043","type":"journal-article","created":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T08:30:22Z","timestamp":1654590622000},"page":"64-72","source":"Crossref","is-referenced-by-count":7,"title":["Association between instrumental activities of daily living frequency and clinical outcomes in older patients with cardiovascular disease"],"prefix":"10.1093","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4141-2506","authenticated-orcid":false,"given":"Hidenori","family":"Kariya","sequence":"first","affiliation":[{"name":"Department of Rehabilitation, Kitasato University Hospital , 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa 252-0373 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3890-3777","authenticated-orcid":false,"given":"Minako","family":"Yamaoka-Tojo","sequence":"additional","affiliation":[{"name":"Kitasato University Regenerative Medicine and Cell Design Research Facility , Sagamihara , Japan"},{"name":"Department of Rehabilitation, Kitasato University School of Allied Health Sciences , Sagamihara , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8338-2141","authenticated-orcid":false,"given":"Nobuaki","family":"Hamazaki","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Kitasato University Hospital , 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa 252-0373 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2310-5089","authenticated-orcid":false,"given":"Shinichi","family":"Obara","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Kitasato University Hospital , 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa 252-0373 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0714-6980","authenticated-orcid":false,"given":"Lisa","family":"Kitasato","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Kitasato University School of Medicine , Sagamihara , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0190-707X","authenticated-orcid":false,"given":"Atsuhiko","family":"Matsunaga","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Kitasato University School of Allied Health Sciences , Sagamihara , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6645-6404","authenticated-orcid":false,"given":"Junya","family":"Ako","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Kitasato University School of Medicine , Sagamihara , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,6,7]]},"reference":[{"key":"2023011123562900700_zvac043-B1","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1253\/circj.CJ-11-0135","article-title":"Trend of westernization of etiology and clinical characteristics of 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