{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T01:08:53Z","timestamp":1789261733154,"version":"build-2803163510"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T00:00:00Z","timestamp":1659398400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100006190","name":"Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006190","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007212","name":"Region V\u00e4stra G\u00f6taland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007212","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007687","name":"Svenska L\u00e4kares\u00e4llskapet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007687","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005754","name":"Sahlgrenska University Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005754","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Supervised exercise is a guideline-recommended treatment in intermittent claudication (IC). Hospital-based supervised exercise programmes (SEPs) are underutilized, while home-based structured exercise programmes (HSEPs) have attracted interest. The results from HSEP in IC are inconsistent and may confer no benefit over walk advice (WA) and be less effective than SEP. The aim of the study was to compare the effectiveness of best medical treatment, including Nordic pole WA alone, or WA + SEP or WA + HSEP for patients with IC.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>This three-armed, multicentre randomized clinical trial enrolled patients with IC; all patients received best medical treatment including walking poles and the advice of regular Nordic pole walking (WA). For HSEP and SEP, additional exercise programmes were provided. The primarily investigated hypothesis was a non-inferiority analysis of SEP vs. HSEP regarding the 6-min walk test (6MWT) maximum distance, with a pre-defined non-inferiority margin of 50 m. Supporting outcomes included muscle endurance tests and the walking impairment questionnaire. Outcomes were assessed at baseline, 3, 6, and 12 months by a blinded evaluator. Altogether 166 patients (mean age 72 years; 59% males) were randomized. In HSEP and SEP, 24 and 26% patients, respectively, were fully exercise adherent. All three groups improved pain-free walking distance over time, but there were no significant intergroup differences. The intergroup 6MWT difference between SEP and HSEP from 0 to 12 months was \u201311.6 m, 95% confidence interval: \u201336.4 to 13.0 m (i.e. within the pre-specified non-inferiority margin).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The HSEP was non-inferior to SEP in patients with IC. There were no significant differences observed between the three groups at 1 year.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Registration<\/jats:title>\n                  <jats:p>ClinicialTrials.gov: NCT02341716.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/eurjcn\/zvac070","type":"journal-article","created":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T16:21:55Z","timestamp":1659457315000},"page":"400-411","source":"Crossref","is-referenced-by-count":19,"title":["Effectiveness of supervised exercise, home-based exercise, or walk advice strategies on walking performance and muscle endurance in patients with intermittent claudication (SUNFIT trial): a randomized clinical trial"],"prefix":"10.1093","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5843-2784","authenticated-orcid":false,"given":"Anna","family":"Sandberg","sequence":"first","affiliation":[{"name":"Department of Occupational Therapy and Physiotherapy, Sahlgrenska University Hospital , Vita str\u00e5ket 13, Gothenburg SE-413 45 , Sweden"},{"name":"Department of Molecular and Clinical Medicine, Sahlgrenska Academy, Institute of Medicine, University of Gothenburg , Gothenburg , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6031-7478","authenticated-orcid":false,"given":"Maria","family":"B\u00e4ck","sequence":"additional","affiliation":[{"name":"Department of Occupational Therapy and Physiotherapy, Sahlgrenska University Hospital , Vita str\u00e5ket 13, Gothenburg SE-413 45 , Sweden"},{"name":"Department of Molecular and Clinical Medicine, Sahlgrenska Academy, Institute of Medicine, University of Gothenburg , Gothenburg , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2140-8569","authenticated-orcid":false,"given":"\u00c5sa","family":"Cider","sequence":"additional","affiliation":[{"name":"Department of Occupational Therapy and Physiotherapy, Sahlgrenska University Hospital , Vita str\u00e5ket 13, Gothenburg SE-413 45 , Sweden"},{"name":"Department of Health and Rehabilitation\/Physiotherapy, Sahlgrenska Academy, Institute of Neuroscience and Physiology, University of Gothenburg , Gothenburg , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1071-7761","authenticated-orcid":false,"given":"Lennart","family":"Jiveg\u00e5rd","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Medicine, Sahlgrenska Academy, Institute of Medicine, University of Gothenburg , Gothenburg , Sweden"},{"name":"Health Technology Assessment Centre Region V\u00e4stra G\u00f6taland, Sahlgrenska University Hospital , Gothenburg , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8186-135X","authenticated-orcid":false,"given":"Birgitta","family":"Sigvant","sequence":"additional","affiliation":[{"name":"Department of Surgical Science, Uppsala University Hospital , Uppsala , Sweden"},{"name":"Department of Vascular Surgery, Central Hospital Karlstad , Karlstad , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanna","family":"Wittboldt","sequence":"additional","affiliation":[{"name":"Department of Occupational Therapy and Physiotherapy, Sahlgrenska University Hospital , Vita str\u00e5ket 13, Gothenburg SE-413 45 , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2670-2268","authenticated-orcid":false,"given":"Joakim","family":"Nordanstig","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Medicine, Sahlgrenska Academy, Institute of Medicine, 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