{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:57:04Z","timestamp":1777499824642,"version":"3.51.4"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T00:00:00Z","timestamp":1663632000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"ZOLL Respicardia, Inc."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Sleep disorder breathing is an important non-cardiovascular comorbidity in patients with heart failure (HF). However, central sleep apnoea (CSA) remains poorly diagnosed and treated. This post hoc analysis examined symptoms and quality of life in patients with CSA and HF following 12 months of transvenous phrenic nerve stimulation (TPNS) therapy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Patients enrolled in the remed\u0113 System Pivotal trial were invited to complete self-reported questionnaires. Symptoms and responses to three validated questionnaires were examined. Percentage of patients noting an impairment was calculated at baseline. At 12 months, % of patients experiencing improvement, no change, or worsening was calculated. Shifts from symptom presence at baseline to absence at 12 months were assessed for those symptoms experienced by \u226550% of patients at baseline. Seventy-five patients were included. Most frequently reported symptoms were fatigue and daytime sleepiness. Following 12 months of TPNS, a variety of subjective improvements were observed; 45% of patients indicating cessation of daytime sleepiness, 44% cessation of fatigue\/weakness, and 52% no longer having difficulty falling\/staying asleep. Specific questions related to tiredness\/fatigue, motivation, and chance of dozing provided an insight into potential areas of improvement. Furthermore, at least 60% of patients reported resolution of insomnia\/fragmented sleep and snoring on therapy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Adult patients with CSA and HF experience distressing symptoms and limitations. Transvenous phrenic nerve stimulation was found to improve many of these. Awareness of key symptoms or limitations patients experience can be used to inform the development of a CSA-specific patient questionnaire to identify CSA sooner and aid treatment decisions.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/eurjcn\/zvac086","type":"journal-article","created":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T17:24:00Z","timestamp":1663694640000},"page":"489-497","source":"Crossref","is-referenced-by-count":3,"title":["Transvenous phrenic nerve stimulation to treat central sleep apnoea in patients with heart failure may improve sleep, quality of life, and symptoms"],"prefix":"10.1093","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5232-0936","authenticated-orcid":false,"given":"Loreena","family":"Hill","sequence":"first","affiliation":[{"name":"School of Nursing and Midwifery, Medical Biology Building, Queen's University , 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy","family":"Meyer","sequence":"additional","affiliation":[{"name":"ZOLL Respicardia, Inc. , 12400 Whitewater Dr #150, Minnetonka, MN 55343 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2886-6864","authenticated-orcid":false,"given":"Scott","family":"McKane","sequence":"additional","affiliation":[{"name":"ZOLL Respicardia, Inc. , 12400 Whitewater Dr #150, Minnetonka, MN 55343 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5922-4098","authenticated-orcid":false,"given":"Mitja","family":"Lainscak","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Ljubljana , Kongresni trg 12, SI-1000 Ljubljana , Slovenia"},{"name":"Division of Cardiology, General Hospital Murska Sobota , Ulica dr. Vrbnjaka 6, SI-9000 Murska Sobota , Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qanta A","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Sleep Disorders Medicine, Division of Pulmonary Disease and Critical Care Medicine, Department of Medicine, NYU Langone Long Island Hospital, NYU Langone Long Island School of Medicine , 101 Mineola Blvd, Mineola, NY 11501 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,9,20]]},"reference":[{"key":"2023071901372104700_zvac086-B1","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1056\/NEJMe058229","article-title":"Sleep\u2013a new cardiovascular frontier","volume":"353","author":"Somers","year":"2005","journal-title":"N Engl J Med"},{"key":"2023071901372104700_zvac086-B2","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1093\/eurjhf\/hfp057","article-title":"Sleep-disordered breathing in heart failure with normal left ventricular ejection fraction","volume":"11","author":"Bitter","year":"2009","journal-title":"Eur J Heart Fail"},{"key":"2023071901372104700_zvac086-B3","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.cjca.2018.03.006","article-title":"Prevalence and clinical correlates of sleep-disordered breathing in patients hospitalized with acute decompensated heart failure","volume":"34","author":"Suda","year":"2018","journal-title":"Can J Cardiol"},{"key":"2023071901372104700_zvac086-B4","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ijcard.2004.12.068","article-title":"Sleep disorders in systolic heart failure: a prospective study of 100 male patients. 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